| 1 | Sat 30 Jul 2022 | 31-0 v BarnsleyPlymouth Argyle 1-0 Barnsley | Sky Bet League One |
| 2 | Sat 6 Aug 2022 | 3 1-2 v Fleetwood TownFleetwood Town 2-1 Plymouth Argyle | Sky Bet League One |
| 3 | Wed 10 Aug 2022 | 30-2 v Peterborough UnitedPlymouth Argyle 0-2 Peterborough United | Carabao Cup First Round |
| 4 | Sat 13 Aug 2022 | 32-0 v Peterborough UnitedPlymouth Argyle 2-0 Peterborough United | Sky Bet League One |
| 5 | Tue 16 Aug 2022 | 31-5 v Charlton AthleticCharlton Athletic 5-1 Plymouth Argyle | Sky Bet League One |
| 6 | Sat 20 Aug 2022 | 33-0 v Forest Green RoversForest Green Rovers 0-3 Plymouth Argyle | Sky Bet League One |
| 7 | Sat 27 Aug 2022 | 32-0 v Bolton WanderersPlymouth Argyle 2-0 Bolton Wanderers | Sky Bet League One |
| 8 | Tue 30 Aug 2022 | 31-1 v Bristol RoversPlymouth Argyle 1-1 Bristol Rovers | Papa John’s Trophy |
| 9 | Sat 3 Sep 2022 | 33-2 v Derby CountyDerby County 2-3 Plymouth Argyle | Sky Bet League One |
| 10 | Tue 13 Sep 2022 | 31-0 v Oxford UnitedPlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 11 | Sat 17 Sep 2022 | 32-2 v PortsmouthPortsmouth 2-2 Plymouth Argyle | Sky Bet League One |
| 12 | Sun 25 Sep 2022 | 32-1 v Ipswich TownPlymouth Argyle 2-1 Ipswich Town | Sky Bet League One |
| 13 | Sat 19 Nov 2022 | 32-2 v Burton AlbionBurton Albion 2-2 Plymouth Argyle | Sky Bet League One |
| 14 | Fri 2 Dec 2022 | 30-2 v Port ValePlymouth Argyle 0-2 Port Vale | Sky Bet League One |
| 15 | Sat 10 Dec 2022 | 30-0 v Cambridge UnitedCambridge United 0-0 Plymouth Argyle | Sky Bet League One |
| 16 | Sat 17 Dec 2022 | 32-1 v MorecambePlymouth Argyle 2-1 Morecambe | Sky Bet League One |
| 17 | Mon 26 Dec 2022 | 31-0 v Cheltenham TownCheltenham Town 0-1 Plymouth Argyle | Sky Bet League One |
| 18 | Thu 29 Dec 2022 | 31-0 v Wycombe WanderersPlymouth Argyle 1-0 Wycombe Wanderers | Sky Bet League One |
| 19 | Sat 7 Jan 2023 | 30-0 v Bolton WanderersBolton Wanderers 0-0 Plymouth Argyle | Sky Bet League One |
| 20 | Tue 10 Jan 2023 | 32-0 v Bristol RoversBristol Rovers 0-2 Plymouth Argyle | Papa John’s Trophy Northern Group D |
| 21 | Sat 14 Jan 2023 | 31-1 v Ipswich TownIpswich Town 1-1 Plymouth Argyle | Sky Bet League One |
| 22 | Sat 21 Jan 2023 | 34-2 v Cheltenham TownPlymouth Argyle 4-2 Cheltenham Town | Sky Bet League One |
| 23 | Sat 4 Feb 2023 | 30-1 v Sheffield WednesdaySheffield Wednesday 1-0 Plymouth Argyle | Sky Bet League One |
| 24 | Sat 11 Feb 2023 | 33-1 v PortsmouthPlymouth Argyle 3-1 Portsmouth | Sky Bet League One |
| 25 | Tue 14 Feb 2023 | 33-1 v Oxford UnitedOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 26 | Sat 18 Feb 2023 | 30-0 v Fleetwood TownPlymouth Argyle 0-0 Fleetwood Town | Sky Bet League One |
| 27 | Tue 21 Feb 2023 | 31-1 v Cheltenham TownPlymouth Argyle 1-1 Cheltenham Town | Papa John’s Trophy Northern Group E |
| 28 | Sat 25 Feb 2023 | 32-5 v Peterborough UnitedPeterborough United 5-2 Plymouth Argyle | Sky Bet League One |
| 29 | Sat 4 Mar 2023 | 32-0 v Charlton AthleticPlymouth Argyle 2-0 Charlton Athletic | Sky Bet League One |
| 30 | Tue 7 Mar 2023 | 32-1 v Derby CountyPlymouth Argyle 2-1 Derby County | Sky Bet League One |
| 31 | Sat 11 Mar 2023 | 30-3 v BarnsleyBarnsley 3-0 Plymouth Argyle | Sky Bet League One |
| 32 | Sat 18 Mar 2023 | 32-0 v Forest Green RoversPlymouth Argyle 2-0 Forest Green Rovers | Sky Bet League One |
| 33 | Tue 21 Mar 2023 | 32-0 v Accrington StanleyAccrington Stanley 0-2 Plymouth Argyle | Sky Bet League One |
| 34 | Sun 2 Apr 2023 | 30-4 v Bolton WanderersBolton Wanderers 4-0 Plymouth Argyle | Papa John’s Trophy Final |
| 35 | Sat 15 Apr 2023 | 31-0 v Exeter CityExeter City 0-1 Plymouth Argyle | Sky Bet League One |
| 36 | Tue 18 Apr 2023 | 32-1 v Shrewsbury TownShrewsbury Town 1-2 Plymouth Argyle | Sky Bet League One |
| 37 | Sat 22 Apr 2023 | 33-1 v Cambridge UnitedPlymouth Argyle 3-1 Cambridge United | Sky Bet League One |
| 38 | Tue 25 Apr 2023 | 32-0 v Bristol RoversPlymouth Argyle 2-0 Bristol Rovers | Sky Bet League One |
| 39 | Sat 29 Apr 2023 | 31-0 v Burton AlbionPlymouth Argyle 1-0 Burton Albion | Sky Bet League One |
| 40 | Sun 7 May 2023 | 33-1 v Port ValePort Vale 1-3 Plymouth Argyle | Sky Bet League One |
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