| 1 | Sat 30 Jul 2022 | 41-0 v Milton Keynes DonsCambridge United 1-0 Milton Keynes Dons | Sky Bet League One |
| 2 | Tue 2 Aug 2022 | 41-0 v MillwallCambridge United 1-0 Millwall | Carabao Cup First Round |
| 3 | Sat 6 Aug 2022 | 40-1 v Oxford UnitedOxford United 1-0 Cambridge United | Sky Bet League One |
| 4 | Tue 16 Aug 2022 | 41-4 v PortsmouthPortsmouth 4-1 Cambridge United | Sky Bet League One |
| 5 | Sat 20 Aug 2022 | 41-1 v Charlton AthleticCharlton Athletic 1-1 Cambridge United | Sky Bet League One |
| 6 | Tue 23 Aug 2022 | 40-3 v SouthamptonCambridge United 0-3 Southampton | Carabao Cup Second Round |
| 7 | Sat 27 Aug 2022 | 4 4-3 v Burton AlbionCambridge United 4-3 Burton Albion | Sky Bet League One |
| 8 | Sat 3 Sep 2022 | 42-0 v Lincoln CityCambridge United 2-0 Lincoln City | Sky Bet League One |
| 9 | Tue 13 Sep 2022 | 41-2 v Cheltenham TownCheltenham Town 2-1 Cambridge United | Sky Bet League One |
| 10 | Sat 17 Sep 2022 | 40-3 v BarnsleyCambridge United 0-3 Barnsley | Sky Bet League One |
| 11 | Sat 24 Sep 2022 | 42-1 v MorecambeMorecambe 1-2 Cambridge United | Sky Bet League One |
| 12 | Sat 1 Oct 2022 | 40-2 v Derby CountyCambridge United 0-2 Derby County | Sky Bet League One |
| 13 | Tue 4 Oct 2022 | 40-3 v Ipswich TownIpswich Town 3-0 Cambridge United | Sky Bet League One |
| 14 | Sat 8 Oct 2022 | 4 1-2 v Bristol RoversBristol Rovers 2-1 Cambridge United | Sky Bet League One |
| 15 | Sat 15 Oct 2022 | 40-2 v Sheffield WednesdayCambridge United 0-2 Sheffield Wednesday | Sky Bet League One |
| 16 | Sat 22 Oct 2022 | 40-1 v Port ValeCambridge United 0-1 Port Vale | Sky Bet League One |
| 17 | Tue 25 Oct 2022 | 43-2 v Wycombe WanderersWycombe Wanderers 2-3 Cambridge United | Sky Bet League One |
| 18 | Sat 29 Oct 2022 | 40-1 v Peterborough UnitedPeterborough United 1-0 Cambridge United | Sky Bet League One |
| 19 | Sat 12 Nov 2022 | 4 0-0 v Bolton WanderersCambridge United 0-0 Bolton Wanderers | Sky Bet League One |
| 20 | Tue 15 Nov 2022 | 40-0 v Curzon AshtonCambridge United 0-0 Curzon Ashton | Emirates FA Cup First Round Replay |
| 21 | Sat 19 Nov 2022 | 40-1 v Accrington StanleyCambridge United 0-1 Accrington Stanley | Sky Bet League One |
| 22 | Sat 26 Nov 2022 | 4 1-2 v Grimsby TownCambridge United 1-2 Grimsby Town | Emirates FA Cup Second Round |
| 23 | Sat 3 Dec 2022 | 41-2 v Forest Green RoversForest Green Rovers 2-1 Cambridge United | Sky Bet League One |
| 24 | Sat 10 Dec 2022 | 40-0 v Plymouth ArgyleCambridge United 0-0 Plymouth Argyle | Sky Bet League One |
| 25 | Mon 26 Dec 2022 | 42-1 v Shrewsbury TownCambridge United 2-1 Shrewsbury Town | Sky Bet League One |
| 26 | Fri 30 Dec 2022 | 40-1 v Derby CountyDerby County 1-0 Cambridge United | Sky Bet League One |
| 27 | Mon 2 Jan 2023 | 40-5 v Sheffield WednesdaySheffield Wednesday 5-0 Cambridge United | Sky Bet League One |
| 28 | Sat 7 Jan 2023 | 4 1-2 v Bristol RoversCambridge United 1-2 Bristol Rovers | Sky Bet League One |
| 29 | Sat 21 Jan 2023 | 4 1-5 v Shrewsbury TownShrewsbury Town 5-1 Cambridge United | Sky Bet League One |
| 30 | Sat 28 Jan 2023 | 4 0-0 v Lincoln CityLincoln City 0-0 Cambridge United | Sky Bet League One |
| 31 | Sat 4 Feb 2023 | 4 1-1 v Ipswich TownCambridge United 1-1 Ipswich Town | Sky Bet League One |
| 32 | Sat 11 Feb 2023 | 4 0-2 v BarnsleyBarnsley 2-0 Cambridge United | Sky Bet League One |
| 33 | Tue 14 Feb 2023 | 41-2 v Cheltenham TownCambridge United 1-2 Cheltenham Town | Sky Bet League One |
| 34 | Sat 18 Feb 2023 | 41-0 v Oxford UnitedCambridge United 1-0 Oxford United | Sky Bet League One |
| 35 | Tue 21 Feb 2023 | 40-1 v Fleetwood TownFleetwood Town 1-0 Cambridge United | Sky Bet League One |
| 36 | Sat 25 Feb 2023 | 40-2 v Exeter CityExeter City 2-0 Cambridge United | Sky Bet League One |
| 37 | Sat 4 Mar 2023 | 40-1 v PortsmouthCambridge United 0-1 Portsmouth | Sky Bet League One |
| 38 | Tue 7 Mar 2023 | 41-1 v MorecambeCambridge United 1-1 Morecambe | Sky Bet League One |
| 39 | Sat 11 Mar 2023 | 40-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Cambridge United | Sky Bet League One |
| 40 | Sat 18 Mar 2023 | 41-2 v Charlton AthleticCambridge United 1-2 Charlton Athletic | Sky Bet League One |
| 41 | Sat 1 Apr 2023 | 42-0 v Port ValePort Vale 0-2 Cambridge United | Sky Bet League One |
| 42 | Fri 7 Apr 2023 | 42-1 v Fleetwood TownCambridge United 2-1 Fleetwood Town | Sky Bet League One |
| 43 | Mon 10 Apr 2023 | 41-1 v Bolton WanderersBolton Wanderers 1-1 Cambridge United | Sky Bet League One |
| 44 | Sat 15 Apr 2023 | 42-0 v Peterborough UnitedCambridge United 2-0 Peterborough United | Sky Bet League One |
| 45 | Tue 18 Apr 2023 | 41-2 v Wycombe WanderersCambridge United 1-2 Wycombe Wanderers | Sky Bet League One |
| 46 | Sat 22 Apr 2023 | 41-3 v Plymouth ArgylePlymouth Argyle 3-1 Cambridge United | Sky Bet League One |
| 47 | Sat 29 Apr 2023 | 4 2-1 v Accrington StanleyAccrington Stanley 1-2 Cambridge United | Sky Bet League One |
| 48 | Wed 3 May 2023 | 40-1 v Burton AlbionBurton Albion 1-0 Cambridge United | Sky Bet League One |
| 49 | Sun 7 May 2023 | 42-0 v Forest Green RoversCambridge United 2-0 Forest Green Rovers | Sky Bet League One |
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