| 1 | Sat 30 Jul 2022 | 20-2 v Leyton OrientLeyton Orient 2-0 Grimsby Town | Sky Bet League Two |
| 2 | Sat 6 Aug 2022 | 21-1 v Northampton TownGrimsby Town 1-1 Northampton Town | Sky Bet League Two |
| 3 | Tue 9 Aug 2022 | 24-0 v Crewe AlexandraGrimsby Town 4-0 Crewe Alexandra | Carabao Cup First Round |
| 4 | Sat 13 Aug 2022 | 21-0 v RochdaleRochdale 0-1 Grimsby Town | Sky Bet League Two |
| 5 | Sat 20 Aug 2022 | 20-0 v Sutton UnitedGrimsby Town 0-0 Sutton United | Sky Bet League Two |
| 6 | Tue 23 Aug 2022 | 20-3 v Nottingham ForestGrimsby Town 0-3 Nottingham Forest | Carabao Cup Second Round |
| 7 | Sat 27 Aug 2022 | 22-1 v WalsallWalsall 1-2 Grimsby Town | Sky Bet League Two |
| 8 | Sat 3 Sep 2022 | 22-0 v Newport CountyNewport County 0-2 Grimsby Town | Sky Bet League Two |
| 9 | Tue 13 Sep 2022 | 21-1 v GillinghamGrimsby Town 1-1 Gillingham | Sky Bet League Two |
| 10 | Sat 17 Sep 2022 | 2 1-0 v Colchester UnitedColchester United 0-1 Grimsby Town | Sky Bet League Two |
| 11 | Tue 20 Sep 2022 | 22-0 v Mansfield TownGrimsby Town 2-0 Mansfield Town | Papa John’s Trophy |
| 12 | Sat 24 Sep 2022 | 21-2 v Swindon TownGrimsby Town 1-2 Swindon Town | Sky Bet League Two |
| 13 | Sat 8 Oct 2022 | 23-0 v Crawley TownGrimsby Town 3-0 Crawley Town | Sky Bet League Two |
| 14 | Sat 15 Oct 2022 | 2 3-1 v Stockport CountyStockport County 1-3 Grimsby Town | Sky Bet League Two |
| 15 | Sat 22 Oct 2022 | 20-0 v Bradford CityGrimsby Town 0-0 Bradford City | Sky Bet League Two |
| 16 | Tue 25 Oct 2022 | 20-1 v BarrowBarrow 1-0 Grimsby Town | Sky Bet League Two |
| 17 | Sat 29 Oct 2022 | 21-2 v Hartlepool UnitedHartlepool United 2-1 Grimsby Town | Sky Bet League Two |
| 18 | Sat 5 Nov 2022 | 25-1 v Plymouth ArgyleGrimsby Town 5-1 Plymouth Argyle | Emirates FA Cup First Round |
| 19 | Sat 12 Nov 2022 | 21-3 v Doncaster RoversGrimsby Town 1-3 Doncaster Rovers | Sky Bet League Two |
| 20 | Sat 19 Nov 2022 | 21-1 v StevenageGrimsby Town 1-1 Stevenage | Sky Bet League Two |
| 21 | Tue 22 Nov 2022 | 20-1 v Accrington StanleyGrimsby Town 0-1 Accrington Stanley | Papa John’s Trophy Second Round |
| 22 | Sat 26 Nov 2022 | 22-1 v Cambridge UnitedCambridge United 1-2 Grimsby Town | Emirates FA Cup Second Round |
| 23 | Sat 3 Dec 2022 | 20-1 v AFC WimbledonAFC Wimbledon 1-0 Grimsby Town | Sky Bet League Two |
| 24 | Sat 10 Dec 2022 | 22-1 v Tranmere RoversGrimsby Town 2-1 Tranmere Rovers | Sky Bet League Two |
| 25 | Mon 26 Dec 2022 | 22-3 v Harrogate TownHarrogate Town 3-2 Grimsby Town | Sky Bet League Two |
| 26 | Thu 29 Dec 2022 | 21-4 v Salford CityGrimsby Town 1-4 Salford City | Sky Bet League Two |
| 27 | Sun 1 Jan 2023 | 21-0 v Stockport CountyGrimsby Town 1-0 Stockport County | Sky Bet League Two |
| 28 | Sat 7 Jan 2023 | 21-0 v Burton AlbionGrimsby Town 1-0 Burton Albion | Emirates FA Cup Third Round |
| 29 | Sat 14 Jan 2023 | 20-5 v Swindon TownSwindon Town 5-0 Grimsby Town | Sky Bet League Two |
| 30 | Sat 28 Jan 2023 | 22-2 v Luton TownLuton Town 2-2 Grimsby Town | Emirates FA Cup Fourth Round |
| 31 | Sat 4 Feb 2023 | 23-0 v Crewe AlexandraCrewe Alexandra 0-3 Grimsby Town | Sky Bet League Two |
| 32 | Tue 7 Feb 2023 | 2 3-0 v Luton TownGrimsby Town 3-0 Luton Town | Emirates FA Cup Fourth Round Replay |
| 33 | Sat 11 Feb 2023 | 20-1 v Colchester UnitedGrimsby Town 0-1 Colchester United | Sky Bet League Two |
| 34 | Tue 14 Feb 2023 | 21-2 v GillinghamGillingham 2-1 Grimsby Town | Sky Bet League Two |
| 35 | Sat 18 Feb 2023 | 22-1 v Northampton TownNorthampton Town 1-2 Grimsby Town | Sky Bet League Two |
| 36 | Tue 21 Feb 2023 | 20-0 v Harrogate TownGrimsby Town 0-0 Harrogate Town | Sky Bet League Two |
| 37 | Sat 25 Feb 2023 | 22-2 v Leyton OrientGrimsby Town 2-2 Leyton Orient | Sky Bet League Two |
| 38 | Wed 1 Mar 2023 | 22-1 v SouthamptonSouthampton 1-2 Grimsby Town | Emirates FA Cup Fifth Round |
| 39 | Sat 4 Mar 2023 | 20-2 v Carlisle UnitedCarlisle United 2-0 Grimsby Town | Sky Bet League Two |
| 40 | Tue 7 Mar 2023 | 21-1 v Newport CountyGrimsby Town 1-1 Newport County | Sky Bet League Two |
| 41 | Sat 11 Mar 2023 | 21-0 v RochdaleGrimsby Town 1-0 Rochdale | Sky Bet League Two |
| 42 | Tue 14 Mar 2023 | 21-0 v Sutton UnitedSutton United 0-1 Grimsby Town | Sky Bet League Two |
| 43 | Sun 19 Mar 2023 | 20-5 v Brighton & Hove AlbionBrighton & Hove Albion 5-0 Grimsby Town | Emirates FA Cup Quarter Final |
| 44 | Sat 25 Mar 2023 | 21-1 v WalsallGrimsby Town 1-1 Walsall | Sky Bet League Two |
| 45 | Fri 7 Apr 2023 | 21-4 v Hartlepool UnitedGrimsby Town 1-4 Hartlepool United | Sky Bet League Two |
| 46 | Sat 15 Apr 2023 | 2 1-1 v Mansfield TownGrimsby Town 1-1 Mansfield Town | Sky Bet League Two |
| 47 | Sat 22 Apr 2023 | 20-2 v Tranmere RoversTranmere Rovers 2-0 Grimsby Town | Sky Bet League Two |
| 48 | Sat 29 Apr 2023 | 20-2 v StevenageStevenage 2-0 Grimsby Town | Sky Bet League Two |
| 49 | Mon 8 May 2023 | 21-0 v AFC WimbledonGrimsby Town 1-0 AFC Wimbledon | Sky Bet League Two |
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