| 1 | Sat 30 Jul 2022 | 52-0 v Grimsby TownLeyton Orient 2-0 Grimsby Town | Sky Bet League Two |
| 2 | Sat 6 Aug 2022 | 51-0 v Crawley TownCrawley Town 0-1 Leyton Orient | Sky Bet League Two |
| 3 | Sat 13 Aug 2022 | 51-0 v Mansfield TownLeyton Orient 1-0 Mansfield Town | Sky Bet League Two |
| 4 | Sat 20 Aug 2022 | 53-1 v Colchester UnitedColchester United 1-3 Leyton Orient | Sky Bet League Two |
| 5 | Sat 27 Aug 2022 | 54-2 v Hartlepool UnitedLeyton Orient 4-2 Hartlepool United | Sky Bet League Two |
| 6 | Sat 3 Sep 2022 | 52-0 v Tranmere RoversLeyton Orient 2-0 Tranmere Rovers | Sky Bet League Two |
| 7 | Tue 13 Sep 2022 | 51-0 v RochdaleRochdale 0-1 Leyton Orient | Sky Bet League Two |
| 8 | Sat 17 Sep 2022 | 51-0 v WalsallLeyton Orient 1-0 Walsall | Sky Bet League Two |
| 9 | Sat 24 Sep 2022 | 5 2-0 v BarrowBarrow 0-2 Leyton Orient | Sky Bet League Two |
| 10 | Sat 1 Oct 2022 | 5 1-2 v Newport CountyLeyton Orient 1-2 Newport County | Sky Bet League Two |
| 11 | Sat 8 Oct 2022 | 51-1 v Doncaster RoversDoncaster Rovers 1-1 Leyton Orient | Sky Bet League Two |
| 12 | Sat 15 Oct 2022 | 50-0 v Northampton TownLeyton Orient 0-0 Northampton Town | Sky Bet League Two |
| 13 | Sat 22 Oct 2022 | 53-2 v Carlisle UnitedCarlisle United 2-3 Leyton Orient | Sky Bet League Two |
| 14 | Tue 25 Oct 2022 | 5 2-0 v GillinghamLeyton Orient 2-0 Gillingham | Sky Bet League Two |
| 15 | Sat 29 Oct 2022 | 51-0 v Salford CityLeyton Orient 1-0 Salford City | Sky Bet League Two |
| 16 | Tue 8 Nov 2022 | 50-2 v AFC WimbledonAFC Wimbledon 2-0 Leyton Orient | Sky Bet League Two |
| 17 | Sat 12 Nov 2022 | 52-0 v Harrogate TownHarrogate Town 0-2 Leyton Orient | Sky Bet League Two |
| 18 | Sat 19 Nov 2022 | 52-1 v Stockport CountyStockport County 1-2 Leyton Orient | Sky Bet League Two |
| 19 | Sat 3 Dec 2022 | 53-0 v Bradford CityLeyton Orient 3-0 Bradford City | Sky Bet League Two |
| 20 | Sat 17 Dec 2022 | 52-0 v Sutton UnitedLeyton Orient 2-0 Sutton United | Sky Bet League Two |
| 21 | Tue 27 Dec 2022 | 50-0 v StevenageLeyton Orient 0-0 Stevenage | Sky Bet League Two |
| 22 | Fri 30 Dec 2022 | 50-0 v Newport CountyNewport County 0-0 Leyton Orient | Sky Bet League Two |
| 23 | Mon 2 Jan 2023 | 50-1 v Northampton TownNorthampton Town 1-0 Leyton Orient | Sky Bet League Two |
| 24 | Sat 29 Apr 2023 | 50-3 v Stockport CountyLeyton Orient 0-3 Stockport County | Sky Bet League Two |
| 25 | Mon 8 May 2023 | 51-1 v Bradford CityBradford City 1-1 Leyton Orient | Sky Bet League Two |
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