| 1 | Tue 2 Aug 2022 | 12-2 v MacclesfieldMacclesfield 2-2 FC United of Manchester | Friendly |
| 2 | Sat 13 Aug 2022 | 11-2 v Atherton CollieriesFC United of Manchester 1-2 Atherton Collieries | Northern Premier League - Premier Division |
| 3 | Tue 16 Aug 2022 | 14-1 v Belper TownBelper Town 1-4 FC United of Manchester | Northern Premier League - Premier Division |
| 4 | Sat 20 Aug 2022 | 12-0 v Whitby TownWhitby Town 0-2 FC United of Manchester | Northern Premier League - Premier Division |
| 5 | Tue 23 Aug 2022 | 10-0 v Nantwich TownFC United of Manchester 0-0 Nantwich Town | Northern Premier League - Premier Division |
| 6 | Sat 27 Aug 2022 | 11-2 v Bamber BridgeBamber Bridge 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 7 | Mon 29 Aug 2022 | 11-2 v RadcliffeFC United of Manchester 1-2 Radcliffe | Northern Premier League - Premier Division |
| 8 | Sat 3 Sep 2022 | 11-0 v Witton AlbionWitton Albion 0-1 FC United of Manchester | Emirates FA Cup First Qualifying Round |
| 9 | Tue 6 Sep 2022 | 10-1 v Hyde UnitedHyde United 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 10 | Tue 13 Sep 2022 | 12-1 v Matlock TownFC United of Manchester 2-1 Matlock Town | Northern Premier League - Premier Division |
| 11 | Sat 17 Sep 2022 | 12-3 v Curzon AshtonFC United of Manchester 2-3 Curzon Ashton | Emirates FA Cup Second Qualifying Round |
| 12 | Sat 8 Oct 2022 | 10-1 v LiversedgeFC United of Manchester 0-1 Liversedge | Isuzu FA Trophy Third Qualifying Round |
| 13 | Sat 22 Oct 2022 | 11-1 v Lancaster CityFC United of Manchester 1-1 Lancaster City | Northern Premier League - Premier Division |
| 14 | Sat 29 Oct 2022 | 14-1 v Stalybridge CelticFC United of Manchester 4-1 Stalybridge Celtic | Manchester Premier Cup First Round |
| 15 | Sat 5 Nov 2022 | 12-1 v Stalybridge CelticStalybridge Celtic 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 16 | Sat 12 Nov 2022 | 12-2 v Warrington RylandsFC United of Manchester 2-2 Warrington Rylands | Northern Premier League - Premier Division |
| 17 | Tue 15 Nov 2022 | 14-1 v KSV BeverenFC United of Manchester 4-1 KSV Beveren | Friendly |
| 18 | Sat 19 Nov 2022 | 11-3 v Gainsborough TrinityFC United of Manchester 1-3 Gainsborough Trinity | Northern Premier League - Premier Division |
| 19 | Sat 26 Nov 2022 | 10-1 v Stafford RangersStafford Rangers 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 20 | Sat 3 Dec 2022 | 12-0 v Belper TownFC United of Manchester 2-0 Belper Town | Northern Premier League - Premier Division |
| 21 | Mon 26 Dec 2022 | 14-0 v Ashton UnitedFC United of Manchester 4-0 Ashton United | Northern Premier League - Premier Division |
| 22 | Mon 2 Jan 2023 | 10-1 v RadcliffeRadcliffe 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 23 | Sat 7 Jan 2023 | 12-2 v Whitby TownFC United of Manchester 2-2 Whitby Town | Northern Premier League - Premier Division |
| 24 | Sat 14 Jan 2023 | 14-4 v Hyde UnitedFC United of Manchester 4-4 Hyde United | Northern Premier League - Premier Division |
| 25 | Tue 24 Jan 2023 | 12-0 v Nantwich TownNantwich Town 0-2 FC United of Manchester | Northern Premier League - Premier Division |
| 26 | Sat 28 Jan 2023 | 11-1 v Warrington TownFC United of Manchester 1-1 Warrington Town | Northern Premier League - Premier Division |
| 27 | Sat 4 Feb 2023 | 10-1 v Matlock TownMatlock Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 28 | Tue 7 Feb 2023 | 11-0 v GuiseleyFC United of Manchester 1-0 Guiseley | Northern Premier League - Premier Division |
| 29 | Sat 11 Feb 2023 | 10-2 v Lancaster CityLancaster City 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 30 | Sat 18 Feb 2023 | 11-1 v Stalybridge CelticFC United of Manchester 1-1 Stalybridge Celtic | Northern Premier League - Premier Division |
| 31 | Sat 25 Feb 2023 | 10-0 v Warrington RylandsWarrington Rylands 0-0 FC United of Manchester | Northern Premier League - Premier Division |
| 32 | Sat 4 Mar 2023 | 12-3 v LiversedgeFC United of Manchester 2-3 Liversedge | Northern Premier League - Premier Division |
| 33 | Sat 11 Mar 2023 | 10-1 v Atherton CollieriesAtherton Collieries 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 34 | Tue 14 Mar 2023 | 12-1 v South ShieldsSouth Shields 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 35 | Sat 25 Mar 2023 | 12-1 v Marske UnitedFC United of Manchester 2-1 Marske United | Northern Premier League - Premier Division |
| 36 | Sat 1 Apr 2023 | 11-0 v Morpeth TownMorpeth Town 0-1 FC United of Manchester | Northern Premier League - Premier Division |
| 37 | Sat 8 Apr 2023 | 15-2 v Bamber BridgeFC United of Manchester 5-2 Bamber Bridge | Northern Premier League - Premier Division |
| 38 | Mon 10 Apr 2023 | 15-0 v Ashton UnitedAshton United 0-5 FC United of Manchester | Northern Premier League - Premier Division |
| 39 | Sat 15 Apr 2023 | 10-1 v Stafford RangersFC United of Manchester 0-1 Stafford Rangers | Northern Premier League - Premier Division |
| 40 | Sat 22 Apr 2023 | 12-1 v Gainsborough TrinityGainsborough Trinity 1-2 FC United of Manchester | Northern Premier League - Premier Division |
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