| 1 | Tue 2 Aug 2022 | 112-2 v MacclesfieldMacclesfield 2-2 FC United of Manchester | Friendly |
| 2 | Sat 13 Aug 2022 | 91-2 v Atherton CollieriesFC United of Manchester 1-2 Atherton Collieries | Northern Premier League - Premier Division |
| 3 | Tue 16 Aug 2022 | 144-1 v Belper TownBelper Town 1-4 FC United of Manchester | Northern Premier League - Premier Division |
| 4 | Sat 20 Aug 2022 | 142-0 v Whitby TownWhitby Town 0-2 FC United of Manchester | Northern Premier League - Premier Division |
| 5 | Tue 23 Aug 2022 | 140-0 v Nantwich TownFC United of Manchester 0-0 Nantwich Town | Northern Premier League - Premier Division |
| 6 | Sat 27 Aug 2022 | 111-2 v Bamber BridgeBamber Bridge 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 7 | Sat 3 Sep 2022 | 141-0 v Witton AlbionWitton Albion 0-1 FC United of Manchester | Emirates FA Cup First Qualifying Round |
| 8 | Tue 6 Sep 2022 | 12 0-1 v Hyde UnitedHyde United 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 9 | Sat 17 Sep 2022 | 142-3 v Curzon AshtonFC United of Manchester 2-3 Curzon Ashton | Emirates FA Cup Second Qualifying Round |
| 10 | Sat 1 Oct 2022 | 9 1-2 v 1874 Northwich1874 Northwich 2-1 Skelmersdale United | Northern Premier League - West Division |
| 11 | Sat 8 Oct 2022 | 9 1-3 v Newcastle TownSkelmersdale United 1-3 Newcastle Town | Northern Premier League - West Division |
| 12 | Sat 15 Oct 2022 | 9 5-3 v Ramsbottom UnitedRamsbottom United 3-5 Skelmersdale United | Northern Premier League - West Division |
| 13 | Sat 22 Oct 2022 | 92-1 v ColneColne 1-2 Skelmersdale United | Northern Premier League - West Division |
| 14 | Sat 29 Oct 2022 | 104-1 v Stalybridge CelticFC United of Manchester 4-1 Stalybridge Celtic | Manchester Premier Cup First Round |
| 15 | Sat 5 Nov 2022 | 112-1 v Stalybridge CelticStalybridge Celtic 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 16 | Tue 15 Nov 2022 | 164-1 v KSV BeverenFC United of Manchester 4-1 KSV Beveren | Friendly |
| 17 | Sat 19 Nov 2022 | 171-3 v Gainsborough TrinityFC United of Manchester 1-3 Gainsborough Trinity | Northern Premier League - Premier Division |
| 18 | Sat 26 Nov 2022 | 9 1-2 v BootleBootle 2-1 Skelmersdale United | Northern Premier League - West Division |
| 19 | Sat 7 Jan 2023 | 102-4 v City of LiverpoolSkelmersdale United 2-4 City of Liverpool | Northern Premier League - West Division |
| 20 | Tue 17 Jan 2023 | 152-4 v Leek TownSkelmersdale United 2-4 Leek Town | Northern Premier League - West Division |
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