| 1 | Sat 9 Jul 2022 | 22-7 v Salford CityWarrington Rylands 2-7 Salford City | Friendly |
| 2 | Sat 16 Jul 2022 | 41-0 v Cammell Laird 1907Cammell Laird 1907 0-1 Warrington Rylands | Friendly |
| 3 | Tue 19 Jul 2022 | 151-2 v ChorleyWarrington Rylands 1-2 Chorley | Friendly |
| 4 | Tue 26 Jul 2022 | 141-0 v Pilkington XXXWarrington Rylands 1-0 Pilkington XXX | Friendly |
| 5 | Sat 1 Oct 2022 | 6 1-2 v 1874 Northwich1874 Northwich 2-1 Skelmersdale United | Northern Premier League - West Division |
| 6 | Sat 8 Oct 2022 | 21-3 v Newcastle TownSkelmersdale United 1-3 Newcastle Town | Northern Premier League - West Division |
| 7 | Sat 15 Oct 2022 | 155-3 v Ramsbottom UnitedRamsbottom United 3-5 Skelmersdale United | Northern Premier League - West Division |
| 8 | Wed 2 Nov 2022 | 23-3 v South LiverpoolSouth Liverpool 3-3 Skelmersdale United | Liverpool County FA Senior Cup First Round |
| 9 | Sat 26 Nov 2022 | 121-2 v BootleBootle 2-1 Skelmersdale United | Northern Premier League - West Division |
| 10 | Sat 3 Dec 2022 | 41-2 v Kidsgrove AthleticSkelmersdale United 1-2 Kidsgrove Athletic | Northern Premier League - West Division |
| 11 | Mon 26 Dec 2022 | 4 2-0 v WidnesSkelmersdale United 2-0 Widnes | Northern Premier League - West Division |
| 12 | Mon 2 Jan 2023 | 41-2 v Prescot CablesPrescot Cables 2-1 Skelmersdale United | Northern Premier League - West Division |
| 13 | Sat 7 Jan 2023 | 42-4 v City of LiverpoolSkelmersdale United 2-4 City of Liverpool | Northern Premier League - West Division |
| 14 | Sat 14 Jan 2023 | 41-0 v ClitheroeClitheroe 0-1 Skelmersdale United | Northern Premier League - West Division |
| 15 | Tue 17 Jan 2023 | 42-4 v Leek TownSkelmersdale United 2-4 Leek Town | Northern Premier League - West Division |
| 16 | Sat 4 Feb 2023 | 120-2 v 1874 NorthwichSkelmersdale United 0-2 1874 Northwich | Northern Premier League - West Division |
| 17 | Sat 18 Feb 2023 | 121-0 v Ramsbottom UnitedSkelmersdale United 1-0 Ramsbottom United | Northern Premier League - West Division |
| 18 | Sat 25 Feb 2023 | 141-0 v Newcastle TownNewcastle Town 0-1 Skelmersdale United | Northern Premier League - West Division |
| 19 | Sat 4 Mar 2023 | 122-1 v ColneSkelmersdale United 2-1 Colne | Northern Premier League - West Division |
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