| 1 | Sat 20 Aug 2022 | 42-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 2 | Tue 23 Aug 2022 | 4 3-0 v Cambridge UnitedCambridge United 0-3 Southampton | Carabao Cup Second Round |
| 3 | Sat 27 Aug 2022 | 40-1 v Manchester UnitedSouthampton 0-1 Manchester United | Premier League |
| 4 | Tue 30 Aug 2022 | 42-1 v ChelseaSouthampton 2-1 Chelsea | Premier League |
| 5 | Wed 19 Oct 2022 | 41-0 v AFC BournemouthAFC Bournemouth 0-1 Southampton | Premier League |
| 6 | Sun 23 Oct 2022 | 4 1-1 v ArsenalSouthampton 1-1 Arsenal | Premier League |
| 7 | Sat 29 Oct 2022 | 4 0-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 8 | Wed 9 Nov 2022 | 41-1 v Sheffield WednesdaySouthampton 1-1 Sheffield Wednesday | Carabao Cup Third Round |
| 9 | Sat 12 Nov 2022 | 41-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 10 | Tue 20 Dec 2022 | 42-1 v Lincoln CitySouthampton 2-1 Lincoln City | Carabao Cup Fourth Round |
| 11 | Mon 26 Dec 2022 | 41-3 v Brighton & Hove AlbionSouthampton 1-3 Brighton & Hove Albion | Premier League |
| 12 | Sat 31 Dec 2022 | 41-2 v FulhamFulham 2-1 Southampton | Premier League |
| 13 | Wed 4 Jan 2023 | 40-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 14 | Sat 7 Jan 2023 | 42-1 v Crystal PalaceCrystal Palace 1-2 Southampton | Emirates FA Cup Third Round |
| 15 | Wed 11 Jan 2023 | 42-0 v Manchester CitySouthampton 2-0 Manchester City | Carabao Cup Quarter Final |
| 16 | Sat 14 Jan 2023 | 4 2-1 v EvertonEverton 1-2 Southampton | Premier League |
| 17 | Sat 21 Jan 2023 | 4 0-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 18 | Tue 24 Jan 2023 | 4 0-1 v Newcastle UnitedSouthampton 0-1 Newcastle United | Carabao Cup Semi Final |
| 19 | Sat 28 Jan 2023 | 42-1 v BlackpoolSouthampton 2-1 Blackpool | Emirates FA Cup Fourth Round |
| 20 | Tue 31 Jan 2023 | 41-2 v Newcastle UnitedNewcastle United 2-1 Southampton | Carabao Cup Semi Final |
| 21 | Sat 11 Feb 2023 | 41-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 22 | Sat 18 Feb 2023 | 41-0 v ChelseaChelsea 0-1 Southampton | Premier League |
| 23 | Wed 1 Mar 2023 | 41-2 v Grimsby TownSouthampton 1-2 Grimsby Town | Emirates FA Cup Fifth Round |
| 24 | Fri 21 Apr 2023 | 43-3 v ArsenalArsenal 3-3 Southampton | Premier League |
| 25 | Thu 27 Apr 2023 | 40-1 v AFC BournemouthSouthampton 0-1 AFC Bournemouth | Premier League |
| 26 | Sun 30 Apr 2023 | 41-3 v Newcastle UnitedNewcastle United 3-1 Southampton | Premier League |
| 27 | Mon 8 May 2023 | 43-4 v Nottingham ForestNottingham Forest 4-3 Southampton | Premier League |
| 28 | Sat 13 May 2023 | 40-2 v FulhamSouthampton 0-2 Fulham | Premier League |
| 29 | Sun 21 May 2023 | 41-3 v Brighton & Hove AlbionBrighton & Hove Albion 3-1 Southampton | Premier League |
| 30 | Sun 28 May 2023 | 44-4 v LiverpoolSouthampton 4-4 Liverpool | Premier League |
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