| 1 | Sat 6 Aug 2022 | 311-4 v Tottenham HotspurTottenham Hotspur 4-1 Southampton | Premier League |
| 2 | Sat 13 Aug 2022 | 312-2 v Leeds UnitedSouthampton 2-2 Leeds United | Premier League |
| 3 | Sat 20 Aug 2022 | 312-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 4 | Sat 27 Aug 2022 | 310-1 v Manchester UnitedSouthampton 0-1 Manchester United | Premier League |
| 5 | Tue 30 Aug 2022 | 312-1 v ChelseaSouthampton 2-1 Chelsea | Premier League |
| 6 | Sat 3 Sep 2022 | 310-1 v Wolverhampton WanderersWolverhampton Wanderers 1-0 Southampton | Premier League |
| 7 | Fri 16 Sep 2022 | 310-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 8 | Sat 24 Sep 2022 | 11-2 v ScotlandScotland 2-1 Republic of Ireland | UEFA Nations League League B Group 1 |
| 9 | Tue 27 Sep 2022 | 13-2 v ArmeniaRepublic of Ireland 3-2 Armenia | UEFA Nations League League B Group 1 |
| 10 | Sat 1 Oct 2022 | 311-2 v EvertonSouthampton 1-2 Everton | Premier League |
| 11 | Sat 8 Oct 2022 | 310-4 v Manchester CityManchester City 4-0 Southampton | Premier League |
| 12 | Sun 16 Oct 2022 | 311-1 v West Ham UnitedSouthampton 1-1 West Ham United | Premier League |
| 13 | Wed 19 Oct 2022 | 311-0 v AFC BournemouthAFC Bournemouth 0-1 Southampton | Premier League |
| 14 | Sun 23 Oct 2022 | 311-1 v ArsenalSouthampton 1-1 Arsenal | Premier League |
| 15 | Sat 29 Oct 2022 | 310-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 16 | Sun 6 Nov 2022 | 311-4 v Newcastle UnitedSouthampton 1-4 Newcastle United | Premier League |
| 17 | Sat 12 Nov 2022 | 311-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 18 | Thu 17 Nov 2022 | 11-2 v NorwayRepublic of Ireland 1-2 Norway | International Friendly |
| 19 | Tue 20 Dec 2022 | 312-1 v Lincoln CitySouthampton 2-1 Lincoln City | Carabao Cup Fourth Round |
| 20 | Mon 26 Dec 2022 | 311-3 v Brighton & Hove AlbionSouthampton 1-3 Brighton & Hove Albion | Premier League |
| 21 | Sat 31 Dec 2022 | 311-2 v FulhamFulham 2-1 Southampton | Premier League |
| 22 | Wed 4 Jan 2023 | 310-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 23 | Sat 7 Jan 2023 | 312-1 v Crystal PalaceCrystal Palace 1-2 Southampton | Emirates FA Cup Third Round |
| 24 | Wed 11 Jan 2023 | 312-0 v Manchester CitySouthampton 2-0 Manchester City | Carabao Cup Quarter Final |
| 25 | Sat 14 Jan 2023 | 312-1 v EvertonEverton 1-2 Southampton | Premier League |
| 26 | Sat 21 Jan 2023 | 310-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 27 | Tue 24 Jan 2023 | 310-1 v Newcastle UnitedSouthampton 0-1 Newcastle United | Carabao Cup Semi Final |
| 28 | Tue 31 Jan 2023 | 311-2 v Newcastle UnitedNewcastle United 2-1 Southampton | Carabao Cup Semi Final |
| 29 | Sat 4 Feb 2023 | 310-3 v BrentfordBrentford 3-0 Southampton | Premier League |
| 30 | Sat 11 Feb 2023 | 311-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 31 | Sat 18 Feb 2023 | 311-0 v ChelseaChelsea 0-1 Southampton | Premier League |
| 32 | Sat 25 Feb 2023 | 310-1 v Leeds UnitedLeeds United 1-0 Southampton | Premier League |
| 33 | Sat 4 Mar 2023 | 311-0 v Leicester CitySouthampton 1-0 Leicester City | Premier League |
| 34 | Sun 12 Mar 2023 | 310-0 v Manchester UnitedManchester United 0-0 Southampton | Premier League |
| 35 | Wed 15 Mar 2023 | 310-2 v BrentfordSouthampton 0-2 Brentford | Premier League |
| 36 | Sat 18 Mar 2023 | 313-3 v Tottenham HotspurSouthampton 3-3 Tottenham Hotspur | Premier League |
| 37 | Sun 2 Apr 2023 | 310-1 v West Ham UnitedWest Ham United 1-0 Southampton | Premier League |
| 38 | Sat 8 Apr 2023 | 311-4 v Manchester CitySouthampton 1-4 Manchester City | Premier League |
| 39 | Sat 15 Apr 2023 | 310-2 v Crystal PalaceSouthampton 0-2 Crystal Palace | Premier League |
| 40 | Fri 21 Apr 2023 | 313-3 v ArsenalArsenal 3-3 Southampton | Premier League |
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