| 1 | Sat 6 Aug 2022 | 21-4 v Tottenham HotspurTottenham Hotspur 4-1 Southampton | Premier League |
| 2 | Sat 13 Aug 2022 | 22-2 v Leeds UnitedSouthampton 2-2 Leeds United | Premier League |
| 3 | Sat 20 Aug 2022 | 22-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 4 | Sat 27 Aug 2022 | 20-1 v Manchester UnitedSouthampton 0-1 Manchester United | Premier League |
| 5 | Tue 30 Aug 2022 | 22-1 v ChelseaSouthampton 2-1 Chelsea | Premier League |
| 6 | Sat 3 Sep 2022 | 20-1 v Wolverhampton WanderersWolverhampton Wanderers 1-0 Southampton | Premier League |
| 7 | Fri 16 Sep 2022 | 20-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 8 | Sat 1 Oct 2022 | 21-2 v EvertonSouthampton 1-2 Everton | Premier League |
| 9 | Sat 8 Oct 2022 | 2 0-4 v Manchester CityManchester City 4-0 Southampton | Premier League |
| 10 | Sun 16 Oct 2022 | 2 1-1 v West Ham UnitedSouthampton 1-1 West Ham United | Premier League |
| 11 | Wed 19 Oct 2022 | 21-0 v AFC BournemouthAFC Bournemouth 0-1 Southampton | Premier League |
| 12 | Tue 20 Dec 2022 | 22-1 v Lincoln CitySouthampton 2-1 Lincoln City | Carabao Cup Fourth Round |
| 13 | Mon 26 Dec 2022 | 21-3 v Brighton & Hove AlbionSouthampton 1-3 Brighton & Hove Albion | Premier League |
| 14 | Sat 31 Dec 2022 | 21-2 v FulhamFulham 2-1 Southampton | Premier League |
| 15 | Wed 4 Jan 2023 | 20-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 16 | Sat 7 Jan 2023 | 2 2-1 v Crystal PalaceCrystal Palace 1-2 Southampton | Emirates FA Cup Third Round |
| 17 | Wed 11 Jan 2023 | 22-0 v Manchester CitySouthampton 2-0 Manchester City | Carabao Cup Quarter Final |
| 18 | Sat 14 Jan 2023 | 22-1 v EvertonEverton 1-2 Southampton | Premier League |
| 19 | Sat 21 Jan 2023 | 20-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 20 | Tue 24 Jan 2023 | 20-1 v Newcastle UnitedSouthampton 0-1 Newcastle United | Carabao Cup Semi Final |
| 21 | Sat 28 Jan 2023 | 22-1 v BlackpoolSouthampton 2-1 Blackpool | Emirates FA Cup Fourth Round |
| 22 | Tue 31 Jan 2023 | 21-2 v Newcastle UnitedNewcastle United 2-1 Southampton | Carabao Cup Semi Final |
| 23 | Sat 25 Feb 2023 | 20-1 v Leeds UnitedLeeds United 1-0 Southampton | Premier League |
| 24 | Wed 1 Mar 2023 | 21-2 v Grimsby TownSouthampton 1-2 Grimsby Town | Emirates FA Cup Fifth Round |
| 25 | Sat 4 Mar 2023 | 21-0 v Leicester CitySouthampton 1-0 Leicester City | Premier League |
| 26 | Sun 12 Mar 2023 | 20-0 v Manchester UnitedManchester United 0-0 Southampton | Premier League |
| 27 | Wed 15 Mar 2023 | 20-2 v BrentfordSouthampton 0-2 Brentford | Premier League |
| 28 | Sat 18 Mar 2023 | 23-3 v Tottenham HotspurSouthampton 3-3 Tottenham Hotspur | Premier League |
| 29 | Sun 2 Apr 2023 | 20-1 v West Ham UnitedWest Ham United 1-0 Southampton | Premier League |
| 30 | Sat 8 Apr 2023 | 21-4 v Manchester CitySouthampton 1-4 Manchester City | Premier League |
| 31 | Sat 15 Apr 2023 | 20-2 v Crystal PalaceSouthampton 0-2 Crystal Palace | Premier League |
| 32 | Fri 21 Apr 2023 | 2 3-3 v ArsenalArsenal 3-3 Southampton | Premier League |
| 33 | Thu 27 Apr 2023 | 20-1 v AFC BournemouthSouthampton 0-1 AFC Bournemouth | Premier League |
| 34 | Sun 30 Apr 2023 | 2 1-3 v Newcastle UnitedNewcastle United 3-1 Southampton | Premier League |
| 35 | Mon 8 May 2023 | 23-4 v Nottingham ForestNottingham Forest 4-3 Southampton | Premier League |
| 36 | Sat 13 May 2023 | 20-2 v FulhamSouthampton 0-2 Fulham | Premier League |
| 37 | Sun 21 May 2023 | 21-3 v Brighton & Hove AlbionBrighton & Hove Albion 3-1 Southampton | Premier League |
| 38 | Sun 28 May 2023 | 24-4 v LiverpoolSouthampton 4-4 Liverpool | Premier League |
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