| 1 | Fri 5 Aug 2022 | 3 0-2 v Trabzonsporİstanbulspor 0-2 Trabzonspor | Turkish Süper Lig |
| 2 | Sat 13 Aug 2022 | 3 0-1 v KayserisporKayserispor 1-0 İstanbulspor | Turkish Süper Lig |
| 3 | Mon 22 Aug 2022 | 30-4 v Konyasporİstanbulspor 0-4 Konyaspor | Turkish Süper Lig |
| 4 | Sat 27 Aug 2022 | 31-0 v AlanyasporAlanyaspor 0-1 İstanbulspor | Turkish Süper Lig |
| 5 | Sun 11 Sep 2022 | 31-1 v SivassporSivasspor 1-1 İstanbulspor | Turkish Süper Lig |
| 6 | Sat 17 Sep 2022 | 32-2 v Beşiktaşİstanbulspor 2-2 Beşiktaş | Turkish Süper Lig |
| 7 | Mon 3 Oct 2022 | 32-1 v Fatih KaragümrükFatih Karagümrük 1-2 İstanbulspor | Turkish Süper Lig |
| 8 | Sat 8 Oct 2022 | 31-2 v Ankaragücüİstanbulspor 1-2 Ankaragücü | Turkish Süper Lig |
| 9 | Fri 21 Oct 2022 | 31-2 v AntalyasporAntalyaspor 2-1 İstanbulspor | Turkish Süper Lig |
| 10 | Sat 5 Nov 2022 | 32-3 v GiresunsporGiresunspor 3-2 İstanbulspor | Turkish Süper Lig |
| 11 | Sun 13 Nov 2022 | 30-1 v Hataysporİstanbulspor 0-1 Hatayspor | Turkish Süper Lig |
| 12 | Sun 25 Dec 2022 | 3 1-2 v GalatasarayGalatasaray 2-1 İstanbulspor | Turkish Süper Lig |
| 13 | Wed 28 Dec 2022 | 32-1 v Kasımpaşa SKİstanbulspor 2-1 Kasımpaşa SK | Turkish Süper Lig |
| 14 | Thu 5 Jan 2023 | 30-6 v Adana DemirsporAdana Demirspor 6-0 İstanbulspor | Turkish Süper Lig |
| 15 | Mon 9 Jan 2023 | 31-1 v Gazişehir Gaziantepİstanbulspor 1-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 16 | Sun 15 Jan 2023 | 32-0 v ÜmraniyesporÜmraniyespor 0-2 İstanbulspor | Turkish Süper Lig |
| 17 | Sun 29 Jan 2023 | 32-4 v Kayserisporİstanbulspor 2-4 Kayserispor | Turkish Süper Lig |
| 18 | Thu 2 Feb 2023 | 31-0 v KonyasporKonyaspor 0-1 İstanbulspor | Turkish Süper Lig |
| 19 | Sun 5 Feb 2023 | 32-1 v Alanyasporİstanbulspor 2-1 Alanyaspor | Turkish Süper Lig |
| 20 | Mon 13 Mar 2023 | 33-0 v Sivassporİstanbulspor 3-0 Sivasspor | Turkish Süper Lig |
| 21 | Sat 18 Mar 2023 | 3 1-3 v BeşiktaşBeşiktaş 3-1 İstanbulspor | Turkish Süper Lig |
| 22 | Sat 8 Apr 2023 | 32-3 v AnkaragücüAnkaragücü 3-2 İstanbulspor | Turkish Süper Lig |
| 23 | Sat 15 Apr 2023 | 31-0 v İstanbul Başakşehirİstanbulspor 1-0 İstanbul Başakşehir | Turkish Süper Lig |
| 24 | Wed 19 Apr 2023 | 3 3-3 v Antalyasporİstanbulspor 3-3 Antalyaspor | Turkish Süper Lig |
| 25 | Mon 24 Apr 2023 | 33-3 v FenerbahçeFenerbahçe 3-3 İstanbulspor | Turkish Süper Lig |
| 26 | Mon 1 May 2023 | 31-0 v Giresunsporİstanbulspor 1-0 Giresunspor | Turkish Süper Lig |
| 27 | Tue 16 May 2023 | 3 0-2 v Galatasarayİstanbulspor 0-2 Galatasaray | Turkish Süper Lig |
| 28 | Sat 20 May 2023 | 30-1 v Kasımpaşa SKKasımpaşa SK 1-0 İstanbulspor | Turkish Süper Lig |
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