| 1 | Sat 31 Jul 2021 | 8 0-5 v AFC BournemouthAFC Bournemouth 5-0 Milton Keynes Dons | Carabao Cup First Round |
| 2 | Tue 28 Sep 2021 | 83-3 v Fleetwood TownMilton Keynes Dons 3-3 Fleetwood Town | Sky Bet League One |
| 3 | Tue 5 Oct 2021 | 82-1 v Wycombe WanderersMilton Keynes Dons 2-1 Wycombe Wanderers | Papa John’s Trophy |
| 4 | Sat 16 Oct 2021 | 80-1 v Shrewsbury TownShrewsbury Town 1-0 Milton Keynes Dons | Sky Bet League One |
| 5 | Tue 19 Oct 2021 | 8 2-1 v Wigan AthleticWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 6 | Sat 23 Oct 2021 | 8 0-3 v Rotherham UnitedMilton Keynes Dons 0-3 Rotherham United | Sky Bet League One |
| 7 | Sat 30 Oct 2021 | 84-1 v Crewe AlexandraCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 8 | Sat 13 Nov 2021 | 8 4-1 v Cambridge UnitedMilton Keynes Dons 4-1 Cambridge United | Sky Bet League One |
| 9 | Tue 16 Nov 2021 | 8 1-2 v StevenageStevenage 2-1 Milton Keynes Dons | Emirates FA Cup First Round Replay |
| 10 | Sat 20 Nov 2021 | 8 1-0 v Burton AlbionMilton Keynes Dons 1-0 Burton Albion | Sky Bet League One |
| 11 | Tue 23 Nov 2021 | 81-2 v Sheffield WednesdaySheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 12 | Sun 26 Dec 2021 | 83-2 v Lincoln CityLincoln City 2-3 Milton Keynes Dons | Sky Bet League One |
| 13 | Sat 1 Jan 2022 | 80-0 v GillinghamMilton Keynes Dons 0-0 Gillingham | Sky Bet League One |
| 14 | Tue 4 Jan 2022 | 8 0-1 v Charlton AthleticCharlton Athletic 1-0 Milton Keynes Dons | Papa John’s Trophy Third Round |
| 15 | Sat 8 Jan 2022 | 81-1 v Accrington StanleyAccrington Stanley 1-1 Milton Keynes Dons | Sky Bet League One |
| 16 | Sat 19 Feb 2022 | 82-1 v SunderlandSunderland 1-2 Milton Keynes Dons | Sky Bet League One |
| 17 | Tue 22 Feb 2022 | 82-0 v Charlton AthleticCharlton Athletic 0-2 Milton Keynes Dons | Sky Bet League One |
| 18 | Sat 26 Feb 2022 | 82-0 v Bolton WanderersMilton Keynes Dons 2-0 Bolton Wanderers | Sky Bet League One |
| 19 | Sat 5 Mar 2022 | 8 2-1 v Rotherham UnitedRotherham United 1-2 Milton Keynes Dons | Sky Bet League One |
| 20 | Tue 8 Mar 2022 | 83-1 v Cheltenham TownMilton Keynes Dons 3-1 Cheltenham Town | Sky Bet League One |
| 21 | Sat 12 Mar 2022 | 8 1-1 v Wigan AthleticMilton Keynes Dons 1-1 Wigan Athletic | Sky Bet League One |
| 22 | Sat 19 Mar 2022 | 8 1-0 v Cambridge UnitedCambridge United 0-1 Milton Keynes Dons | Sky Bet League One |
| 23 | Sat 2 Apr 2022 | 82-0 v Shrewsbury TownMilton Keynes Dons 2-0 Shrewsbury Town | Sky Bet League One |
| 24 | Sat 16 Apr 2022 | 82-3 v Sheffield WednesdayMilton Keynes Dons 2-3 Sheffield Wednesday | Sky Bet League One |
| 25 | Tue 19 Apr 2022 | 80-1 v Oxford UnitedOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 26 | Sat 23 Apr 2022 | 8 2-0 v MorecambeMilton Keynes Dons 2-0 Morecambe | Sky Bet League One |
| 27 | Sat 30 Apr 2022 | 85-0 v Plymouth ArgylePlymouth Argyle 0-5 Milton Keynes Dons | Sky Bet League One |
| 28 | Thu 5 May 2022 | 80-2 v Wycombe WanderersWycombe Wanderers 2-0 Milton Keynes Dons | Sky Bet League One Play-off Semi Final |
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