| 1 | Sun 8 Aug 2021 | 282-3 v MarseilleMontpellier 2-3 Marseille | French Ligue 1 |
| 2 | Sun 15 Aug 2021 | 283-3 v ReimsReims 3-3 Montpellier | French Ligue 1 |
| 3 | Wed 22 Sep 2021 | 283-3 v BordeauxMontpellier 3-3 Bordeaux | French Ligue 1 |
| 4 | Sat 25 Sep 2021 | 28 0-2 v Paris St GermainParis St Germain 2-0 Montpellier | French Ligue 1 |
| 5 | Sat 2 Oct 2021 | 281-1 v StrasbourgMontpellier 1-1 Strasbourg | French Ligue 1 |
| 6 | Sun 24 Oct 2021 | 28 1-3 v MonacoMonaco 3-1 Montpellier | French Ligue 1 |
| 7 | Sun 7 Nov 2021 | 281-0 v NiceNice 0-1 Montpellier | French Ligue 1 |
| 8 | Sat 20 Nov 2021 | 280-2 v RennesRennes 2-0 Montpellier | French Ligue 1 |
| 9 | Sun 28 Nov 2021 | 280-1 v LyonMontpellier 0-1 Lyon | French Ligue 1 |
| 10 | Wed 1 Dec 2021 | 283-1 v MetzMetz 1-3 Montpellier | French Ligue 1 |
| 11 | Sun 16 Jan 2022 | 281-3 v StrasbourgStrasbourg 3-1 Montpellier | French Ligue 1 |
| 12 | Sat 5 Feb 2022 | 281-3 v Saint ÉtienneSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 13 | Sat 12 Feb 2022 | 280-1 v LilleMontpellier 0-1 Lille | French Ligue 1 |
| 14 | Fri 25 Feb 2022 | 282-4 v RennesMontpellier 2-4 Rennes | French Ligue 1 |
| 15 | Sun 6 Mar 2022 | 280-2 v NantesNantes 2-0 Montpellier | French Ligue 1 |
| 16 | Sat 12 Mar 2022 | 28 0-0 v NiceMontpellier 0-0 Nice | French Ligue 1 |
| 17 | Sun 3 Apr 2022 | 281-2 v BrestMontpellier 1-2 Brest | French Ligue 1 |
| 18 | Sun 10 Apr 2022 | 280-2 v MarseilleMarseille 2-0 Montpellier | French Ligue 1 |
| 19 | Sun 17 Apr 2022 | 280-0 v ReimsMontpellier 0-0 Reims | French Ligue 1 |
| 20 | Sun 8 May 2022 | 281-2 v ClermontClermont 2-1 Montpellier | French Ligue 1 |
| 21 | Sat 21 May 2022 | 28 0-2 v AngersAngers 2-0 Montpellier | French Ligue 1 |
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