| 1 | Sun 12 Sep 2021 | 2-0 v Saint ÉtienneMontpellier 2-0 Saint Étienne | French Ligue 1 |
| 2 | Wed 22 Sep 2021 | 233-3 v BordeauxMontpellier 3-3 Bordeaux | French Ligue 1 |
| 3 | Sat 25 Sep 2021 | 230-2 v Paris St GermainParis St Germain 2-0 Montpellier | French Ligue 1 |
| 4 | Sat 2 Oct 2021 | 231-1 v StrasbourgMontpellier 1-1 Strasbourg | French Ligue 1 |
| 5 | Sun 17 Oct 2021 | 231-0 v LensMontpellier 1-0 Lens | French Ligue 1 |
| 6 | Sun 24 Oct 2021 | 231-3 v MonacoMonaco 3-1 Montpellier | French Ligue 1 |
| 7 | Sun 31 Oct 2021 | 232-0 v NantesMontpellier 2-0 Nantes | French Ligue 1 |
| 8 | Sun 7 Nov 2021 | 231-0 v NiceNice 0-1 Montpellier | French Ligue 1 |
| 9 | Sat 20 Nov 2021 | 230-2 v RennesRennes 2-0 Montpellier | French Ligue 1 |
| 10 | Sun 28 Nov 2021 | 230-1 v LyonMontpellier 0-1 Lyon | French Ligue 1 |
| 11 | Wed 1 Dec 2021 | 233-1 v MetzMetz 1-3 Montpellier | French Ligue 1 |
| 12 | Sat 11 Dec 2021 | 234-0 v BrestBrest 0-4 Montpellier | French Ligue 1 |
| 13 | Wed 22 Dec 2021 | 234-1 v AngersMontpellier 4-1 Angers | French Ligue 1 |
| 14 | Sun 16 Jan 2022 | 231-3 v StrasbourgStrasbourg 3-1 Montpellier | French Ligue 1 |
| 15 | Sun 23 Jan 2022 | 233-2 v MonacoMontpellier 3-2 Monaco | French Ligue 1 |
| 16 | Sat 5 Feb 2022 | 231-3 v Saint ÉtienneSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 17 | Sat 12 Feb 2022 | 230-1 v LilleMontpellier 0-1 Lille | French Ligue 1 |
| 18 | Sun 6 Mar 2022 | 230-2 v NantesNantes 2-0 Montpellier | French Ligue 1 |
| 19 | Sun 3 Apr 2022 | 231-2 v BrestMontpellier 1-2 Brest | French Ligue 1 |
| 20 | Wed 20 Apr 2022 | 230-2 v LensLens 2-0 Montpellier | French Ligue 1 |
| 21 | Sat 23 Apr 2022 | 232-5 v LyonLyon 5-2 Montpellier | French Ligue 1 |
| 22 | Sun 1 May 2022 | 232-2 v MetzMontpellier 2-2 Metz | French Ligue 1 |
| 23 | Sun 8 May 2022 | 231-2 v ClermontClermont 2-1 Montpellier | French Ligue 1 |
| 24 | Sat 14 May 2022 | 230-4 v Paris St GermainMontpellier 0-4 Paris St Germain | French Ligue 1 |
| 25 | Sat 21 May 2022 | 230-2 v AngersAngers 2-0 Montpellier | French Ligue 1 |
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