| 1 | 14/8/2021 | 93-2 v Stalybridge CelticNantwich Town 3-2 Stalybridge Celtic | Northern Premier League - Premier Division |
| 2 | 17/8/2021 | 92-0 v Atherton CollieriesAtherton Collieries 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 3 | 21/8/2021 | 90-2 v Whitby TownWhitby Town 2-0 Nantwich Town | Northern Premier League - Premier Division |
| 4 | 24/8/2021 | 90-1 v Matlock TownNantwich Town 0-1 Matlock Town | Northern Premier League - Premier Division |
| 5 | 28/8/2021 | 90-1 v Bamber BridgeNantwich Town 0-1 Bamber Bridge | Northern Premier League - Premier Division |
| 6 | 30/8/2021 | 121-0 v Witton AlbionWitton Albion 0-1 Nantwich Town | Northern Premier League - Premier Division |
| 7 | 4/9/2021 | 142-0 v Grantham TownNantwich Town 2-0 Grantham Town | Emirates FA Cup First Qualifying Round |
| 8 | 7/9/2021 | 140-2 v Hyde UnitedNantwich Town 0-2 Hyde United | Northern Premier League - Premier Division |
| 9 | 11/9/2021 | 91-3 v RadcliffeRadcliffe 3-1 Nantwich Town | Northern Premier League - Premier Division |
| 10 | 14/9/2021 | 140-0 v MickleoverMickleover 0-0 Nantwich Town | Northern Premier League - Premier Division |
| 11 | 18/9/2021 | 91-2 v Banbury UnitedNantwich Town 1-2 Banbury United | Emirates FA Cup Second Qualifying Round |
| 12 | 2/10/2021 | 120-0 v South ShieldsNantwich Town 0-0 South Shields | Northern Premier League - Premier Division |
| 13 | 9/10/2021 | 122-0 v FC United of ManchesterFC United of Manchester 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 14 | 12/10/2021 | 121-1 v Warrington TownNantwich Town 1-1 Warrington Town | Northern Premier League - Premier Division |
| 15 | 16/10/2021 | 121-2 v Ashton UnitedAshton United 2-1 Nantwich Town | Northern Premier League - Premier Division |
| 16 | 23/10/2021 | 122-3 v Morpeth TownNantwich Town 2-3 Morpeth Town | Northern Premier League - Premier Division |
| 17 | 30/10/2021 | 122-1 v BarwellNantwich Town 2-1 Barwell | Buildbase FA Trophy Third Qualifying Round |
| 18 | 13/11/2021 | 142-1 v Grantham TownNantwich Town 2-1 Grantham Town | Buildbase FA Trophy First Round |
| 19 | 20/11/2021 | 80-3 v Scarborough AthleticScarborough Athletic 3-0 Nantwich Town | Northern Premier League - Premier Division |
| 20 | 11/12/2021 | 172-3 v RadcliffeNantwich Town 2-3 Radcliffe | Northern Premier League - Premier Division |
| 21 | 18/12/2021 | 121-2 v King's Lynn TownKing's Lynn Town 2-1 Nantwich Town | Buildbase FA Trophy Third Round |
| 22 | 21/12/2021 | 120-2 v Lancaster CityNantwich Town 0-2 Lancaster City | Northern Premier League - Premier Division |
| 23 | 27/12/2021 | 122-2 v Stafford RangersStafford Rangers 2-2 Nantwich Town | Northern Premier League - Premier Division |
| 24 | 22/1/2022 | 140-1 v Basford UnitedBasford United 1-0 Nantwich Town | Northern Premier League - Premier Division |
| 25 | 25/1/2022 | 100-1 v MickleoverNantwich Town 0-1 Mickleover | Northern Premier League - Premier Division |
| 26 | 29/1/2022 | 102-2 v Ashton UnitedNantwich Town 2-2 Ashton United | Northern Premier League - Premier Division |
| 27 | 5/2/2022 | 82-1 v Morpeth TownMorpeth Town 1-2 Nantwich Town | Northern Premier League - Premier Division |
| 28 | 8/2/2022 | 141-2 v Warrington TownWarrington Town 2-1 Nantwich Town | Northern Premier League - Premier Division |
| 29 | 12/2/2022 | 111-3 v BuxtonNantwich Town 1-3 Buxton | Northern Premier League - Premier Division |
| 30 | 15/2/2022 | 115-1 v Stalybridge CelticStalybridge Celtic 1-5 Nantwich Town | Northern Premier League - Premier Division |
| 31 | 26/2/2022 | 112-4 v South ShieldsSouth Shields 4-2 Nantwich Town | Northern Premier League - Premier Division |
| 32 | 1/3/2022 | 111-0 v Witton AlbionNantwich Town 1-0 Witton Albion | Northern Premier League - Premier Division |
| 33 | 12/3/2022 | 122-0 v FC United of ManchesterNantwich Town 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 34 | 19/3/2022 | 110-0 v Gainsborough TrinityGainsborough Trinity 0-0 Nantwich Town | Northern Premier League - Premier Division |
| 35 | 22/3/2022 | 111-0 v Grantham TownNantwich Town 1-0 Grantham Town | Northern Premier League - Premier Division |
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