| 1 | 14/8/2021 | 93-2 v Stalybridge CelticNantwich Town 3-2 Stalybridge Celtic | Northern Premier League - Premier Division |
| 2 | 17/8/2021 | 92-0 v Atherton CollieriesAtherton Collieries 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 3 | 21/8/2021 | 90-2 v Whitby TownWhitby Town 2-0 Nantwich Town | Northern Premier League - Premier Division |
| 4 | 24/8/2021 | 90-1 v Matlock TownNantwich Town 0-1 Matlock Town | Northern Premier League - Premier Division |
| 5 | 28/8/2021 | 90-1 v Bamber BridgeNantwich Town 0-1 Bamber Bridge | Northern Premier League - Premier Division |
| 6 | 30/8/2021 | 121-0 v Witton AlbionWitton Albion 0-1 Nantwich Town | Northern Premier League - Premier Division |
| 7 | 4/9/2021 | 142-0 v Grantham TownNantwich Town 2-0 Grantham Town | Emirates FA Cup First Qualifying Round |
| 8 | 7/9/2021 | 140-2 v Hyde UnitedNantwich Town 0-2 Hyde United | Northern Premier League - Premier Division |
| 9 | 11/9/2021 | 91-3 v RadcliffeRadcliffe 3-1 Nantwich Town | Northern Premier League - Premier Division |
| 10 | 14/9/2021 | 140-0 v MickleoverMickleover 0-0 Nantwich Town | Northern Premier League - Premier Division |
| 11 | 18/9/2021 | 91-2 v Banbury UnitedNantwich Town 1-2 Banbury United | Emirates FA Cup Second Qualifying Round |
| 12 | 2/10/2021 | 120-0 v South ShieldsNantwich Town 0-0 South Shields | Northern Premier League - Premier Division |
| 13 | 9/10/2021 | 122-0 v FC United of ManchesterFC United of Manchester 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 14 | 12/10/2021 | 121-1 v Warrington TownNantwich Town 1-1 Warrington Town | Northern Premier League - Premier Division |
| 15 | 16/10/2021 | 121-2 v Ashton UnitedAshton United 2-1 Nantwich Town | Northern Premier League - Premier Division |
| 16 | 23/10/2021 | 122-3 v Morpeth TownNantwich Town 2-3 Morpeth Town | Northern Premier League - Premier Division |
| 17 | 30/10/2021 | 122-1 v BarwellNantwich Town 2-1 Barwell | Buildbase FA Trophy Third Qualifying Round |
| 18 | 13/11/2021 | 142-1 v Grantham TownNantwich Town 2-1 Grantham Town | Buildbase FA Trophy First Round |
| 19 | 20/11/2021 | 80-3 v Scarborough AthleticScarborough Athletic 3-0 Nantwich Town | Northern Premier League - Premier Division |
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