| 1 | Sat 19 Aug | 53-1 v FrosinoneFrosinone 1-3 Napoli | Italian Serie A |
| 2 | Sun 27 Aug | 52-0 v SassuoloNapoli 2-0 Sassuolo | Italian Serie A |
| 3 | Sat 2 Sep | 51-2 v LazioNapoli 1-2 Lazio | Italian Serie A |
| 4 | Sat 16 Sep | 52-2 v GenoaGenoa 2-2 Napoli | Italian Serie A |
| 5 | Wed 20 Sep | 5 2-1 v Sporting BragaSporting Braga 1-2 Napoli | UEFA Champions League Group C |
| 6 | Sat 25 Nov | 52-1 v AtalantaAtalanta 1-2 Napoli | Italian Serie A |
| 7 | Wed 29 Nov | 52-4 v Real MadridReal Madrid 4-2 Napoli | UEFA Champions League Group C |
| 8 | Fri 8 Dec | 5 0-1 v JuventusJuventus 1-0 Napoli | Italian Serie A |
| 9 | Tue 12 Dec | 52-0 v Sporting BragaNapoli 2-0 Sporting Braga | UEFA Champions League Group C |
| 10 | Sat 16 Dec | 52-1 v CagliariNapoli 2-1 Cagliari | Italian Serie A |
| 11 | Sat 23 Dec | 5 0-2 v RomaRoma 2-0 Napoli | Italian Serie A |
| 12 | Fri 29 Dec | 5 0-0 v MonzaNapoli 0-0 Monza | Italian Serie A |
| 13 | Sun 7 Jan | 5 0-3 v TorinoTorino 3-0 Napoli | Italian Serie A |
| 14 | Sat 13 Jan | 52-1 v SalernitanaNapoli 2-1 Salernitana | Italian Serie A |
| 15 | Sun 28 Jan | 50-0 v LazioLazio 0-0 Napoli | Italian Serie A |
| 16 | Sun 4 Feb | 52-1 v Hellas VeronaNapoli 2-1 Hellas Verona | Italian Serie A |
| 17 | Sun 11 Feb | 5 0-1 v AC MilanAC Milan 1-0 Napoli | Italian Serie A |
| 18 | Wed 21 Feb | 51-1 v BarcelonaNapoli 1-1 Barcelona | UEFA Champions League Round of 16 |
| 19 | Sun 25 Feb | 51-1 v CagliariCagliari 1-1 Napoli | Italian Serie A |
| 20 | Sun 3 Mar | 52-1 v JuventusNapoli 2-1 Juventus | Italian Serie A |
| 21 | Fri 8 Mar | 5 1-1 v TorinoNapoli 1-1 Torino | Italian Serie A |
| 22 | Tue 12 Mar | 5 1-3 v BarcelonaBarcelona 3-1 Napoli | UEFA Champions League Round of 16 |
| 23 | Sun 17 Mar | 51-1 v Inter MilanInter Milan 1-1 Napoli | Italian Serie A |
| 24 | Sat 30 Mar | 50-3 v AtalantaNapoli 0-3 Atalanta | Italian Serie A |
| 25 | Sun 7 Apr | 54-2 v MonzaMonza 2-4 Napoli | Italian Serie A |
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