| 1 | Sat 14 Aug 2021 | 140-5 v AjaxAjax 5-0 NEC Nijmegen | Dutch Eredivisie |
| 2 | Fri 20 Aug 2021 | 14 2-0 v PEC ZwolleNEC Nijmegen 2-0 PEC Zwolle | Dutch Eredivisie |
| 3 | Sun 29 Aug 2021 | 141-0 v Heracles AlmeloHeracles Almelo 0-1 NEC Nijmegen | Dutch Eredivisie |
| 4 | Sun 12 Sep 2021 | 140-0 v Willem IINEC Nijmegen 0-0 Willem II | Dutch Eredivisie |
| 5 | Fri 17 Sep 2021 | 141-1 v Sparta RotterdamSparta Rotterdam 1-1 NEC Nijmegen | Dutch Eredivisie |
| 6 | Wed 22 Sep 2021 | 140-3 v FC UtrechtNEC Nijmegen 0-3 FC Utrecht | Dutch Eredivisie |
| 7 | Sun 17 Oct 2021 | 140-1 v VitesseNEC Nijmegen 0-1 Vitesse | Dutch Eredivisie |
| 8 | Sun 5 Dec 2021 | 141-2 v RKC WaalwijkRKC Waalwijk 2-1 NEC Nijmegen | Dutch Eredivisie |
| 9 | Sun 12 Dec 2021 | 141-2 v PSV EindhovenNEC Nijmegen 1-2 PSV Eindhoven | Dutch Eredivisie |
| 10 | Sun 19 Dec 2021 | 142-0 v Go Ahead EaglesGo Ahead Eagles 0-2 NEC Nijmegen | Dutch Eredivisie |
| 11 | Wed 22 Dec 2021 | 141-0 v Willem IIWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 12 | Sun 23 Jan 2022 | 141-4 v FeyenoordNEC Nijmegen 1-4 Feyenoord | Dutch Eredivisie |
| 13 | Sun 13 Feb 2022 | 141-0 v sc Heerenveensc Heerenveen 0-1 NEC Nijmegen | Dutch Eredivisie |
| 14 | Sun 27 Feb 2022 | 141-4 v VitesseVitesse 4-1 NEC Nijmegen | Dutch Eredivisie |
| 15 | Sun 6 Mar 2022 | 141-3 v AZ AlkmaarNEC Nijmegen 1-3 AZ Alkmaar | Dutch Eredivisie |
| 16 | Sat 9 Apr 2022 | 140-2 v FC TwenteNEC Nijmegen 0-2 FC Twente | Dutch Eredivisie |
| 17 | Sat 23 Apr 2022 | 140-1 v AjaxNEC Nijmegen 0-1 Ajax | Dutch Eredivisie |
| 18 | Fri 29 Apr 2022 | 14 0-1 v FC UtrechtFC Utrecht 1-0 NEC Nijmegen | Dutch Eredivisie |
| 19 | Sun 8 May 2022 | 141-0 v Go Ahead EaglesNEC Nijmegen 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 20 | Wed 11 May 2022 | 142-3 v PSV EindhovenPSV Eindhoven 3-2 NEC Nijmegen | Dutch Eredivisie |
| 21 | Sun 15 May 2022 | 140-1 v Fortuna SittardNEC Nijmegen 0-1 Fortuna Sittard | Dutch Eredivisie |
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