| 1 | Sat 12 Aug | 39 5-1 v Aston VillaNewcastle United 5-1 Aston Villa | Premier League |
| 2 | Sat 19 Aug | 39 0-1 v Manchester CityManchester City 1-0 Newcastle United | Premier League |
| 3 | Sun 27 Aug | 391-2 v LiverpoolNewcastle United 1-2 Liverpool | Premier League |
| 4 | Sat 2 Sep | 391-3 v Brighton & Hove AlbionBrighton & Hove Albion 3-1 Newcastle United | Premier League |
| 5 | Sat 16 Sep | 39 1-0 v BrentfordNewcastle United 1-0 Brentford | Premier League |
| 6 | Tue 19 Sep | 390-0 v AC MilanAC Milan 0-0 Newcastle United | UEFA Champions League Group F |
| 7 | Sun 24 Sep | 398-0 v Sheffield UnitedSheffield United 0-8 Newcastle United | Premier League |
| 8 | Wed 27 Sep | 39 1-0 v Manchester CityNewcastle United 1-0 Manchester City | Carabao Cup Third Round |
| 9 | Sat 30 Sep | 392-0 v BurnleyNewcastle United 2-0 Burnley | Premier League |
| 10 | Wed 4 Oct | 39 4-1 v Paris St GermainNewcastle United 4-1 Paris St Germain | UEFA Champions League Group F |
| 11 | Sun 8 Oct | 39 2-2 v West Ham UnitedWest Ham United 2-2 Newcastle United | Premier League |
| 12 | Sat 21 Oct | 394-0 v Crystal PalaceNewcastle United 4-0 Crystal Palace | Premier League |
| 13 | Wed 25 Oct | 39 0-1 v Borussia DortmundNewcastle United 0-1 Borussia Dortmund | UEFA Champions League Group F |
| 14 | Sat 28 Oct | 392-2 v Wolverhampton WanderersWolverhampton Wanderers 2-2 Newcastle United | Premier League |
| 15 | Wed 1 Nov | 393-0 v Manchester UnitedManchester United 0-3 Newcastle United | Carabao Cup Fourth Round |
| 16 | Sat 4 Nov | 39 1-0 v ArsenalNewcastle United 1-0 Arsenal | Premier League |
| 17 | Tue 7 Nov | 390-2 v Borussia DortmundBorussia Dortmund 2-0 Newcastle United | UEFA Champions League Group F |
| 18 | Sat 25 Nov | 394-1 v ChelseaNewcastle United 4-1 Chelsea | Premier League |
| 19 | Tue 28 Nov | 391-1 v Paris St GermainParis St Germain 1-1 Newcastle United | UEFA Champions League Group F |
| 20 | Sat 2 Dec | 391-0 v Manchester UnitedNewcastle United 1-0 Manchester United | Premier League |
| 21 | Thu 7 Dec | 390-3 v EvertonEverton 3-0 Newcastle United | Premier League |
| 22 | Sun 10 Dec | 391-4 v Tottenham HotspurTottenham Hotspur 4-1 Newcastle United | Premier League |
| 23 | Wed 13 Dec | 391-2 v AC MilanNewcastle United 1-2 AC Milan | UEFA Champions League Group F |
| 24 | Sat 16 Dec | 393-0 v FulhamNewcastle United 3-0 Fulham | Premier League |
| 25 | Tue 19 Dec | 39 1-1 v ChelseaChelsea 1-1 Newcastle United | Carabao Cup Quarter Final |
| 26 | Sat 23 Dec | 390-1 v Luton TownLuton Town 1-0 Newcastle United | Premier League |
| 27 | Tue 26 Dec | 39 1-3 v Nottingham ForestNewcastle United 1-3 Nottingham Forest | Premier League |
| 28 | Mon 1 Jan | 39 2-4 v LiverpoolLiverpool 4-2 Newcastle United | Premier League |
| 29 | Sat 6 Jan | 39 3-0 v SunderlandSunderland 0-3 Newcastle United | Emirates FA Cup Third Round |
| 30 | Sat 13 Jan | 39 2-3 v Manchester CityNewcastle United 2-3 Manchester City | Premier League |
| 31 | Sat 27 Jan | 392-0 v FulhamFulham 0-2 Newcastle United | Emirates FA Cup Fourth Round |
| 32 | Tue 30 Jan | 393-1 v Aston VillaAston Villa 1-3 Newcastle United | Premier League |
| 33 | Sat 3 Feb | 394-4 v Luton TownNewcastle United 4-4 Luton Town | Premier League |
| 34 | Sat 10 Feb | 393-2 v Nottingham ForestNottingham Forest 2-3 Newcastle United | Premier League |
| 35 | Sat 17 Feb | 392-2 v AFC BournemouthNewcastle United 2-2 AFC Bournemouth | Premier League |
| 36 | Sat 24 Feb | 391-4 v ArsenalArsenal 4-1 Newcastle United | Premier League |
| 37 | Tue 27 Feb | 391-1 v Blackburn RoversBlackburn Rovers 1-1 Newcastle United | Emirates FA Cup Fifth Round |
| 38 | Sat 2 Mar | 393-0 v Wolverhampton WanderersNewcastle United 3-0 Wolverhampton Wanderers | Premier League |
| 39 | Mon 11 Mar | 392-3 v ChelseaChelsea 3-2 Newcastle United | Premier League |
| 40 | Sat 16 Mar | 390-2 v Manchester CityManchester City 2-0 Newcastle United | Emirates FA Cup Quarter Final |
| 41 | Sat 30 Mar | 394-3 v West Ham UnitedNewcastle United 4-3 West Ham United | Premier League |
| 42 | Tue 2 Apr | 391-1 v EvertonNewcastle United 1-1 Everton | Premier League |
| 43 | Sat 6 Apr | 391-0 v FulhamFulham 0-1 Newcastle United | Premier League |
| 44 | Sat 13 Apr | 394-0 v Tottenham HotspurNewcastle United 4-0 Tottenham Hotspur | Premier League |
| 45 | Wed 24 Apr | 390-2 v Crystal PalaceCrystal Palace 2-0 Newcastle United | Premier League |
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