| 1 | Sat 7 Aug 2021 | 41-0 v Oldham AthleticOldham Athletic 0-1 Newport County | Sky Bet League Two |
| 2 | Tue 10 Aug 2021 | 41-0 v Ipswich TownIpswich Town 0-1 Newport County | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 41-2 v Mansfield TownMansfield Town 2-1 Newport County | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 4 1-0 v Tranmere RoversTranmere Rovers 0-1 Newport County | Sky Bet League Two |
| 5 | Wed 25 Aug 2021 | 4 0-8 v SouthamptonNewport County 0-8 Southampton | Carabao Cup Second Round |
| 6 | Sat 28 Aug 2021 | 4 0-3 v Salford CitySalford City 3-0 Newport County | Sky Bet League Two |
| 7 | Sat 4 Sep 2021 | 42-2 v Leyton OrientNewport County 2-2 Leyton Orient | Sky Bet League Two |
| 8 | Fri 10 Sep 2021 | 42-2 v Harrogate TownHarrogate Town 2-2 Newport County | Sky Bet League Two |
| 9 | Sat 18 Sep 2021 | 4 2-1 v WalsallNewport County 2-1 Walsall | Sky Bet League Two |
| 10 | Fri 24 Sep 2021 | 41-2 v BarrowBarrow 2-1 Newport County | Sky Bet League Two |
| 11 | Sat 2 Oct 2021 | 43-0 v Scunthorpe UnitedNewport County 3-0 Scunthorpe United | Sky Bet League Two |
| 12 | Sat 9 Oct 2021 | 40-0 v Bradford CityNewport County 0-0 Bradford City | Sky Bet League Two |
| 13 | Sat 16 Oct 2021 | 42-2 v Exeter CityExeter City 2-2 Newport County | Sky Bet League Two |
| 14 | Tue 19 Oct 2021 | 4 2-2 v Carlisle UnitedNewport County 2-2 Carlisle United | Sky Bet League Two |
| 15 | Sat 30 Oct 2021 | 45-0 v StevenageNewport County 5-0 Stevenage | Sky Bet League Two |
| 16 | Tue 9 Nov 2021 | 4 0-1 v Swindon TownSwindon Town 1-0 Newport County | Papa John’s Trophy |
| 17 | Fri 12 Nov 2021 | 4 2-1 v Hartlepool UnitedHartlepool United 1-2 Newport County | Sky Bet League Two |
| 18 | Sat 20 Nov 2021 | 41-2 v Swindon TownNewport County 1-2 Swindon Town | Sky Bet League Two |
| 19 | Tue 23 Nov 2021 | 4 1-1 v Crawley TownCrawley Town 1-1 Newport County | Sky Bet League Two |
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