| 1 | Sat 7 Aug 2021 | 10 1-0 v Port ValeNorthampton Town 1-0 Port Vale | Sky Bet League Two |
| 2 | Wed 11 Aug 2021 | 102-1 v Coventry CityCoventry City 1-2 Northampton Town | Carabao Cup First Round |
| 3 | Sat 21 Aug 2021 | 101-3 v RochdaleNorthampton Town 1-3 Rochdale | Sky Bet League Two |
| 4 | Tue 24 Aug 2021 | 100-1 v AFC WimbledonNorthampton Town 0-1 AFC Wimbledon | Carabao Cup Second Round |
| 5 | Sat 28 Aug 2021 | 10 0-0 v Crawley TownCrawley Town 0-0 Northampton Town | Sky Bet League Two |
| 6 | Tue 31 Aug 2021 | 101-1 v Forest Green RoversForest Green Rovers 1-1 Northampton Town | Papa John’s Trophy |
| 7 | Sat 4 Sep 2021 | 102-0 v Scunthorpe UnitedNorthampton Town 2-0 Scunthorpe United | Sky Bet League Two |
| 8 | Sat 11 Sep 2021 | 100-1 v Forest Green RoversForest Green Rovers 1-0 Northampton Town | Sky Bet League Two |
| 9 | Tue 14 Sep 2021 | 101-0 v Newport CountyNewport County 0-1 Northampton Town | Sky Bet League Two |
| 10 | Sat 18 Sep 2021 | 101-1 v Swindon TownNorthampton Town 1-1 Swindon Town | Sky Bet League Two |
| 11 | Sat 25 Sep 2021 | 102-2 v Salford CitySalford City 2-2 Northampton Town | Sky Bet League Two |
| 12 | Tue 5 Oct 2021 | 101-1 v WalsallNorthampton Town 1-1 Walsall | Papa John’s Trophy |
| 13 | Sat 9 Oct 2021 | 101-2 v Hartlepool UnitedHartlepool United 2-1 Northampton Town | Sky Bet League Two |
| 14 | Tue 19 Oct 2021 | 103-0 v StevenageNorthampton Town 3-0 Stevenage | Sky Bet League Two |
| 15 | Sat 6 Nov 2021 | 102-2 v Cambridge UnitedNorthampton Town 2-2 Cambridge United | Emirates FA Cup First Round |
| 16 | Sat 13 Nov 2021 | 101-2 v Bristol RoversBristol Rovers 2-1 Northampton Town | Sky Bet League Two |
| 17 | Tue 16 Nov 2021 | 101-3 v Cambridge UnitedCambridge United 3-1 Northampton Town | Emirates FA Cup First Round Replay |
| 18 | Tue 23 Nov 2021 | 102-1 v Oldham AthleticNorthampton Town 2-1 Oldham Athletic | Sky Bet League Two |
| 19 | Sat 11 Dec 2021 | 102-1 v Harrogate TownHarrogate Town 1-2 Northampton Town | Sky Bet League Two |
| 20 | Sat 1 Jan 2022 | 102-5 v Swindon TownSwindon Town 5-2 Northampton Town | Sky Bet League Two |
| 21 | Sat 8 Jan 2022 | 100-1 v Crawley TownNorthampton Town 0-1 Crawley Town | Sky Bet League Two |
| 22 | Sat 15 Jan 2022 | 101-1 v Forest Green RoversNorthampton Town 1-1 Forest Green Rovers | Sky Bet League Two |
| 23 | Sat 22 Jan 2022 | 100-0 v Sutton UnitedSutton United 0-0 Northampton Town | Sky Bet League Two |
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