| 1 | Mon 23 Aug 2021 | 39 0-0 v Celta VigoOsasuna 0-0 Celta Vigo | Spanish La Liga |
| 2 | Sun 29 Aug 2021 | 393-2 v CádizCádiz 2-3 Osasuna | Spanish La Liga |
| 3 | Sun 12 Sep 2021 | 391-4 v ValenciaOsasuna 1-4 Valencia | Spanish La Liga |
| 4 | Sat 18 Sep 2021 | 39 2-0 v AlavésAlavés 0-2 Osasuna | Spanish La Liga |
| 5 | Thu 23 Sep 2021 | 391-3 v Real BetisOsasuna 1-3 Real Betis | Spanish La Liga |
| 6 | Sun 26 Sep 2021 | 393-2 v MallorcaMallorca 2-3 Osasuna | Spanish La Liga |
| 7 | Sat 2 Oct 2021 | 391-0 v Rayo VallecanoOsasuna 1-0 Rayo Vallecano | Spanish La Liga |
| 8 | Sun 17 Oct 2021 | 392-1 v VillarrealVillarreal 1-2 Osasuna | Spanish La Liga |
| 9 | Fri 22 Oct 2021 | 391-1 v GranadaOsasuna 1-1 Granada | Spanish La Liga |
| 10 | Wed 27 Oct 2021 | 390-0 v Real MadridReal Madrid 0-0 Osasuna | Spanish La Liga |
| 11 | Sun 7 Nov 2021 | 390-2 v Real SociedadOsasuna 0-2 Real Sociedad | Spanish La Liga |
| 12 | Sat 20 Nov 2021 | 390-1 v Atlético MadridAtlético Madrid 1-0 Osasuna | Spanish La Liga |
| 13 | Mon 29 Nov 2021 | 39 1-1 v ElcheOsasuna 1-1 Elche | Spanish La Liga |
| 14 | Sun 5 Dec 2021 | 390-0 v LevanteLevante 0-0 Osasuna | Spanish La Liga |
| 15 | Sun 12 Dec 2021 | 39 2-2 v BarcelonaOsasuna 2-2 Barcelona | Spanish La Liga |
| 16 | Sun 19 Dec 2021 | 390-1 v GetafeGetafe 1-0 Osasuna | Spanish La Liga |
| 17 | Mon 3 Jan 2022 | 391-3 v Athletic BilbaoOsasuna 1-3 Athletic Bilbao | Spanish La Liga |
| 18 | Sun 9 Jan 2022 | 392-0 v CádizOsasuna 2-0 Cádiz | Spanish La Liga |
| 19 | Wed 19 Jan 2022 | 390-2 v Celta VigoCelta Vigo 2-0 Osasuna | Spanish La Liga |
| 20 | Sun 23 Jan 2022 | 392-0 v GranadaGranada 0-2 Osasuna | Spanish La Liga |
| 21 | Sat 5 Feb 2022 | 39 0-0 v SevillaOsasuna 0-0 Sevilla | Spanish La Liga |
| 22 | Sat 12 Feb 2022 | 393-0 v Rayo VallecanoRayo Vallecano 0-3 Osasuna | Spanish La Liga |
| 23 | Sat 19 Feb 2022 | 390-3 v Atlético MadridOsasuna 0-3 Atlético Madrid | Spanish La Liga |
| 24 | Sun 27 Feb 2022 | 390-1 v Real SociedadReal Sociedad 1-0 Osasuna | Spanish La Liga |
| 25 | Sat 5 Mar 2022 | 391-0 v VillarrealOsasuna 1-0 Villarreal | Spanish La Liga |
| 26 | Sat 19 Mar 2022 | 393-1 v LevanteOsasuna 3-1 Levante | Spanish La Liga |
| 27 | Sun 3 Apr 2022 | 391-4 v Real BetisReal Betis 4-1 Osasuna | Spanish La Liga |
| 28 | Sun 10 Apr 2022 | 391-0 v AlavésOsasuna 1-0 Alavés | Spanish La Liga |
| 29 | Sat 16 Apr 2022 | 392-1 v ValenciaValencia 1-2 Osasuna | Spanish La Liga |
| 30 | Wed 20 Apr 2022 | 391-3 v Real MadridOsasuna 1-3 Real Madrid | Spanish La Liga |
| 31 | Sun 1 May 2022 | 391-1 v ElcheElche 1-1 Osasuna | Spanish La Liga |
| 32 | Sun 8 May 2022 | 39 1-1 v EspanyolEspanyol 1-1 Osasuna | Spanish La Liga |
| 33 | Sun 15 May 2022 | 390-2 v Athletic BilbaoAthletic Bilbao 2-0 Osasuna | Spanish La Liga |
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