| 1 | Tue 8 Jan 2019 | 1-1 v Cheltenham TownCheltenham Town 1-1 Oxford United | Checkatrade Trophy Second Round |
| 2 | Sat 12 Jan 2019 | 2-2 v Fleetwood TownFleetwood Town 2-2 Oxford United | Sky Bet League One |
| 3 | Sat 19 Jan 2019 | 2-1 v PortsmouthOxford United 2-1 Portsmouth | Sky Bet League One |
| 4 | Tue 22 Jan 2019 | 2-5 v BuryBury 5-2 Oxford United | Checkatrade Trophy Fourth Round |
| 5 | Tue 29 Jan 2019 | 2-2 v BarnsleyOxford United 2-2 Barnsley | Sky Bet League One |
| 6 | Sat 2 Feb 2019 | 0-0 v Burton AlbionBurton Albion 0-0 Oxford United | Sky Bet League One |
| 7 | Sat 9 Feb 2019 | 1-1 v SunderlandOxford United 1-1 Sunderland | Sky Bet League One |
| 8 | Sat 16 Feb 2019 | 0-1 v Peterborough UnitedOxford United 0-1 Peterborough United | Sky Bet League One |
| 9 | Tue 19 Feb 2019 | 2-4 v Accrington StanleyAccrington Stanley 4-2 Oxford United | Sky Bet League One |
| 10 | Sat 23 Feb 2019 | 1-0 v BlackpoolBlackpool 0-1 Oxford United | Sky Bet League One |
| 11 | Sat 2 Mar 2019 | 2-1 v Scunthorpe UnitedOxford United 2-1 Scunthorpe United | Sky Bet League One |
| 12 | Sat 9 Mar 2019 | 0-1 v GillinghamGillingham 1-0 Oxford United | Sky Bet League One |
| 13 | Tue 12 Mar 2019 | 0-0 v RochdaleRochdale 0-0 Oxford United | Sky Bet League One |
| 14 | Sat 16 Mar 2019 | 1-0 v Bradford CityOxford United 1-0 Bradford City | Sky Bet League One |
| 15 | Sat 23 Mar 2019 | 1-0 v Coventry CityCoventry City 0-1 Oxford United | Sky Bet League One |
| 16 | Sat 30 Mar 2019 | 2-1 v Wycombe WanderersOxford United 2-1 Wycombe Wanderers | Sky Bet League One |
| 17 | Sat 13 Apr 2019 | 0-0 v AFC WimbledonOxford United 0-0 AFC Wimbledon | Sky Bet League One |
| 18 | Mon 22 Apr 2019 | 3-2 v Shrewsbury TownShrewsbury Town 2-3 Oxford United | Sky Bet League One |
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