| 1 | Sat 5 Sep 2020 | 61-1 v AFC WimbledonOxford United 1-1 AFC Wimbledon | Carabao Cup First Round South |
| 2 | Sat 17 Oct 2020 | 60-2 v Peterborough UnitedPeterborough United 2-0 Oxford United | Sky Bet League One |
| 3 | Tue 20 Oct 2020 | 63-2 v Milton Keynes DonsOxford United 3-2 Milton Keynes Dons | Sky Bet League One |
| 4 | Tue 27 Oct 2020 | 6 0-2 v Charlton AthleticCharlton Athletic 2-0 Oxford United | Sky Bet League One |
| 5 | Sat 31 Oct 2020 | 60-2 v Fleetwood TownFleetwood Town 2-0 Oxford United | Sky Bet League One |
| 6 | Tue 3 Nov 2020 | 63-1 v RochdaleOxford United 3-1 Rochdale | Sky Bet League One |
| 7 | Tue 17 Nov 2020 | 6 0-2 v Crewe AlexandraOxford United 0-2 Crewe Alexandra | Sky Bet League One |
| 8 | Sat 21 Nov 2020 | 6 2-1 v Wigan AthleticWigan Athletic 1-2 Oxford United | Sky Bet League One |
| 9 | Tue 24 Nov 2020 | 61-1 v PortsmouthPortsmouth 1-1 Oxford United | Sky Bet League One |
| 10 | Sat 28 Nov 2020 | 61-2 v Swindon TownOxford United 1-2 Swindon Town | Sky Bet League One |
| 11 | Tue 1 Dec 2020 | 60-0 v Ipswich TownOxford United 0-0 Ipswich Town | Sky Bet League One |
| 12 | Sat 5 Dec 2020 | 6 1-1 v Hull CityOxford United 1-1 Hull City | Sky Bet League One |
| 13 | Sat 12 Dec 2020 | 60-0 v BlackpoolBlackpool 0-0 Oxford United | Sky Bet League One |
| 14 | Tue 15 Dec 2020 | 64-0 v Northampton TownOxford United 4-0 Northampton Town | Sky Bet League One |
| 15 | Sat 26 Dec 2020 | 6 2-0 v AFC WimbledonOxford United 2-0 AFC Wimbledon | Sky Bet League One |
| 16 | Sat 2 Jan 2021 | 65-1 v Burton AlbionBurton Albion 1-5 Oxford United | Sky Bet League One |
| 17 | Tue 12 Jan 2021 | 61-0 v Cambridge UnitedOxford United 1-0 Cambridge United | Papa John’s Trophy Third Round |
| 18 | Sat 23 Jan 2021 | 62-0 v Bristol RoversOxford United 2-0 Bristol Rovers | Sky Bet League One |
| 19 | Tue 26 Jan 2021 | 64-3 v RochdaleRochdale 3-4 Oxford United | Sky Bet League One |
| 20 | Sat 30 Jan 2021 | 6 1-0 v Fleetwood TownOxford United 1-0 Fleetwood Town | Sky Bet League One |
| 21 | Tue 2 Feb 2021 | 63-1 v AFC WimbledonOxford United 3-1 AFC Wimbledon | Papa John’s Trophy Northern Group D |
| 22 | Sat 6 Feb 2021 | 6 2-3 v Doncaster RoversDoncaster Rovers 3-2 Oxford United | Sky Bet League One |
| 23 | Tue 9 Feb 2021 | 62-0 v Bristol RoversBristol Rovers 0-2 Oxford United | Sky Bet League One |
| 24 | Sun 14 Feb 2021 | 62-1 v Wigan AthleticOxford United 2-1 Wigan Athletic | Sky Bet League One |
| 25 | Tue 16 Feb 2021 | 60-2 v Tranmere RoversOxford United 0-2 Tranmere Rovers | Papa John’s Trophy Northern Group E |
| 26 | Sat 20 Feb 2021 | 6 0-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 27 | Tue 23 Feb 2021 | 60-1 v PortsmouthOxford United 0-1 Portsmouth | Sky Bet League One |
| 28 | Sat 27 Feb 2021 | 61-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Oxford United | Sky Bet League One |
| 29 | Tue 2 Mar 2021 | 6 0-0 v Peterborough UnitedOxford United 0-0 Peterborough United | Sky Bet League One |
| 30 | Sat 6 Mar 2021 | 60-0 v Charlton AthleticOxford United 0-0 Charlton Athletic | Sky Bet League One |
| 31 | Tue 9 Mar 2021 | 62-1 v Swindon TownSwindon Town 1-2 Oxford United | Sky Bet League One |
| 32 | Tue 16 Mar 2021 | 63-0 v Doncaster RoversOxford United 3-0 Doncaster Rovers | Sky Bet League One |
| 33 | Sat 20 Mar 2021 | 60-2 v BlackpoolOxford United 0-2 Blackpool | Sky Bet League One |
| 34 | Tue 23 Mar 2021 | 60-1 v Northampton TownNorthampton Town 1-0 Oxford United | Sky Bet League One |
| 35 | Sat 17 Apr 2021 | 63-2 v GillinghamOxford United 3-2 Gillingham | Sky Bet League One |
| 36 | Tue 20 Apr 2021 | 61-2 v AFC WimbledonAFC Wimbledon 2-1 Oxford United | Sky Bet League One |
| 37 | Sat 24 Apr 2021 | 63-1 v Plymouth ArgyleOxford United 3-1 Plymouth Argyle | Sky Bet League One |
| 38 | Sat 1 May 2021 | 63-2 v Shrewsbury TownShrewsbury Town 2-3 Oxford United | Sky Bet League One |
| 39 | Sun 9 May 2021 | 64-0 v Burton AlbionOxford United 4-0 Burton Albion | Sky Bet League One |
| 40 | Tue 18 May 2021 | 60-3 v BlackpoolOxford United 0-3 Blackpool | Sky Bet League One Play-off |
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