| 1 | Sat 6 Feb 2021 | 272-3 v Doncaster RoversDoncaster Rovers 3-2 Oxford United | Sky Bet League One |
| 2 | Tue 9 Feb 2021 | 302-0 v Bristol RoversBristol Rovers 0-2 Oxford United | Sky Bet League One |
| 3 | Sun 14 Feb 2021 | 302-1 v Wigan AthleticOxford United 2-1 Wigan Athletic | Sky Bet League One |
| 4 | Tue 16 Feb 2021 | 300-2 v Tranmere RoversOxford United 0-2 Tranmere Rovers | Papa John’s Trophy Northern Group E |
| 5 | Sat 20 Feb 2021 | 300-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 6 | Tue 23 Feb 2021 | 300-1 v PortsmouthOxford United 0-1 Portsmouth | Sky Bet League One |
| 7 | Sat 27 Feb 2021 | 301-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Oxford United | Sky Bet League One |
| 8 | Tue 2 Mar 2021 | 300-0 v Peterborough UnitedOxford United 0-0 Peterborough United | Sky Bet League One |
| 9 | Sat 6 Mar 2021 | 300-0 v Charlton AthleticOxford United 0-0 Charlton Athletic | Sky Bet League One |
| 10 | Tue 9 Mar 2021 | 302-1 v Swindon TownSwindon Town 1-2 Oxford United | Sky Bet League One |
| 11 | Sat 13 Mar 2021 | 300-2 v Hull CityHull City 2-0 Oxford United | Sky Bet League One |
| 12 | Tue 16 Mar 2021 | 303-0 v Doncaster RoversOxford United 3-0 Doncaster Rovers | Sky Bet League One |
| 13 | Sat 20 Mar 2021 | 300-2 v BlackpoolOxford United 0-2 Blackpool | Sky Bet League One |
| 14 | Tue 23 Mar 2021 | 300-1 v Northampton TownNorthampton Town 1-0 Oxford United | Sky Bet League One |
| 15 | Fri 26 Mar 2021 | 302-1 v Lincoln CityOxford United 2-1 Lincoln City | Sky Bet League One |
| 16 | Fri 2 Apr 2021 | 30 1-3 v SunderlandSunderland 3-1 Oxford United | Sky Bet League One |
| 17 | Mon 5 Apr 2021 | 301-2 v Accrington StanleyOxford United 1-2 Accrington Stanley | Sky Bet League One |
| 18 | Sat 10 Apr 2021 | 306-0 v Crewe AlexandraCrewe Alexandra 0-6 Oxford United | Sky Bet League One |
| 19 | Tue 13 Apr 2021 | 304-1 v Shrewsbury TownOxford United 4-1 Shrewsbury Town | Sky Bet League One |
| 20 | Sat 1 May 2021 | 303-2 v Shrewsbury TownShrewsbury Town 2-3 Oxford United | Sky Bet League One |
| 21 | Tue 18 May 2021 | 300-3 v BlackpoolOxford United 0-3 Blackpool | Sky Bet League One Play-off |
| 22 | Fri 21 May 2021 | 303-3 v BlackpoolBlackpool 3-3 Oxford United | Sky Bet League One Play-off |
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