| 1 | Sat 10 Aug | 32-0 v Norwich CityOxford United 2-0 Norwich City | Sky Bet Championship |
| 2 | Fri 16 Aug | 32-3 v Coventry CityCoventry City 3-2 Oxford United | Sky Bet Championship |
| 3 | Sat 24 Aug | 31-2 v Blackburn RoversBlackburn Rovers 2-1 Oxford United | Sky Bet Championship |
| 4 | Tue 27 Aug | 30-1 v Coventry CityCoventry City 1-0 Oxford United | Carabao Cup Second Round |
| 5 | Sat 31 Aug | 33-1 v Preston North EndOxford United 3-1 Preston North End | Sky Bet Championship |
| 6 | Sat 14 Sep | 31-0 v Stoke CityOxford United 1-0 Stoke City | Sky Bet Championship |
| 7 | Sat 21 Sep | 3 1-2 v Bristol CityBristol City 2-1 Oxford United | Sky Bet Championship |
| 8 | Sat 28 Sep | 30-0 v BurnleyOxford United 0-0 Burnley | Sky Bet Championship |
| 9 | Tue 1 Oct | 32-2 v Luton TownLuton Town 2-2 Oxford United | Sky Bet Championship |
| 10 | Sat 5 Oct | 31-1 v PortsmouthPortsmouth 1-1 Oxford United | Sky Bet Championship |
| 11 | Sat 19 Oct | 31-1 v West Bromwich AlbionOxford United 1-1 West Bromwich Albion | Sky Bet Championship |
| 12 | Tue 22 Oct | 31-1 v Derby CountyOxford United 1-1 Derby County | Sky Bet Championship |
| 13 | Sat 26 Oct | 30-2 v SunderlandSunderland 2-0 Oxford United | Sky Bet Championship |
| 14 | Sat 2 Nov | 31-2 v Swansea CityOxford United 1-2 Swansea City | Sky Bet Championship |
| 15 | Tue 5 Nov | 3 1-0 v Hull CityOxford United 1-0 Hull City | Sky Bet Championship |
| 16 | Fri 8 Nov | 30-1 v WatfordWatford 1-0 Oxford United | Sky Bet Championship |
| 17 | Sat 23 Nov | 32-6 v MiddlesbroughOxford United 2-6 Middlesbrough | Sky Bet Championship |
| 18 | Tue 26 Nov | 30-3 v Sheffield UnitedSheffield United 3-0 Oxford United | Sky Bet Championship |
| 19 | Sat 30 Nov | 31-1 v MillwallOxford United 1-1 Millwall | Sky Bet Championship |
| 20 | Wed 11 Dec | 30-2 v Queens Park RangersQueens Park Rangers 2-0 Oxford United | Sky Bet Championship |
| 21 | Sat 14 Dec | 31-3 v Sheffield WednesdayOxford United 1-3 Sheffield Wednesday | Sky Bet Championship |
| 22 | Sat 21 Dec | 30-4 v Leeds UnitedLeeds United 4-0 Oxford United | Sky Bet Championship |
| 23 | Thu 26 Dec | 33-2 v Cardiff CityOxford United 3-2 Cardiff City | Sky Bet Championship |
| 24 | Sun 29 Dec | 32-0 v Plymouth ArgyleOxford United 2-0 Plymouth Argyle | Sky Bet Championship |
| 25 | Wed 1 Jan | 31-0 v MillwallMillwall 0-1 Oxford United | Sky Bet Championship |
| 26 | Sat 4 Jan | 31-1 v Preston North EndPreston North End 1-1 Oxford United | Sky Bet Championship |
| 27 | Tue 14 Jan | 3 1-1 v Plymouth ArgylePlymouth Argyle 1-1 Oxford United | Sky Bet Championship |
| 28 | Sat 18 Jan | 31-0 v Blackburn RoversOxford United 1-0 Blackburn Rovers | Sky Bet Championship |
| 29 | Tue 21 Jan | 33-2 v Luton TownOxford United 3-2 Luton Town | Sky Bet Championship |
| 30 | Sat 25 Jan | 30-0 v Stoke CityStoke City 0-0 Oxford United | Sky Bet Championship |
| 31 | Sat 1 Feb | 31-1 v Bristol CityOxford United 1-1 Bristol City | Sky Bet Championship |
| 32 | Tue 4 Feb | 30-1 v BurnleyBurnley 1-0 Oxford United | Sky Bet Championship |
| 33 | Tue 11 Feb | 30-0 v Derby CountyDerby County 0-0 Oxford United | Sky Bet Championship |
| 34 | Sat 15 Feb | 30-2 v PortsmouthOxford United 0-2 Portsmouth | Sky Bet Championship |
| 35 | Sat 22 Feb | 30-2 v West Bromwich AlbionWest Bromwich Albion 2-0 Oxford United | Sky Bet Championship |
| 36 | Sat 1 Mar | 3 2-3 v Coventry CityOxford United 2-3 Coventry City | Sky Bet Championship |
| 37 | Fri 7 Mar | 3 1-1 v Norwich CityNorwich City 1-1 Oxford United | Sky Bet Championship |
| 38 | Wed 12 Mar | 3 1-2 v Hull CityHull City 2-1 Oxford United | Sky Bet Championship |
| 39 | Sat 15 Mar | 31-0 v WatfordOxford United 1-0 Watford | Sky Bet Championship |
| 40 | Sat 29 Mar | 31-2 v MiddlesbroughMiddlesbrough 2-1 Oxford United | Sky Bet Championship |
| 41 | Sat 5 Apr | 31-0 v Sheffield UnitedOxford United 1-0 Sheffield United | Sky Bet Championship |
| 42 | Wed 9 Apr | 31-3 v Queens Park RangersOxford United 1-3 Queens Park Rangers | Sky Bet Championship |
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