| 1 | Sat 5 Aug | 180-2 v Cambridge UnitedCambridge United 2-0 Oxford United | Sky Bet League One |
| 2 | Wed 9 Aug | 181-5 v Bristol CityBristol City 5-1 Oxford United | Carabao Cup First Round South |
| 3 | Tue 15 Aug | 182-1 v Derby CountyDerby County 1-2 Oxford United | Sky Bet League One |
| 4 | Sat 19 Aug | 183-1 v BarnsleyBarnsley 1-3 Oxford United | Sky Bet League One |
| 5 | Sat 26 Aug | 18 2-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 6 | Sat 2 Sep | 181-2 v Port ValeOxford United 1-2 Port Vale | Sky Bet League One |
| 7 | Sat 16 Sep | 183-0 v Fleetwood TownFleetwood Town 0-3 Oxford United | Sky Bet League One |
| 8 | Sat 23 Sep | 183-0 v Exeter CityOxford United 3-0 Exeter City | Sky Bet League One |
| 9 | Sat 30 Sep | 183-1 v StevenageStevenage 1-3 Oxford United | Sky Bet League One |
| 10 | Tue 3 Oct | 183-0 v Shrewsbury TownOxford United 3-0 Shrewsbury Town | Sky Bet League One |
| 11 | Sat 7 Oct | 182-1 v Bristol RoversOxford United 2-1 Bristol Rovers | Sky Bet League One |
| 12 | Sat 21 Oct | 181-1 v BlackpoolOxford United 1-1 Blackpool | Sky Bet League One |
| 13 | Tue 24 Oct | 180-2 v Wigan AthleticWigan Athletic 2-0 Oxford United | Sky Bet League One |
| 14 | Sat 28 Oct | 18 2-2 v Wycombe WanderersOxford United 2-2 Wycombe Wanderers | Sky Bet League One |
| 15 | Tue 31 Oct | 182-0 v Lincoln CityLincoln City 0-2 Oxford United | Sky Bet League One |
| 16 | Sat 4 Nov | 182-0 v Maidenhead UnitedOxford United 2-0 Maidenhead United | Emirates FA Cup First Round |
| 17 | Sat 11 Nov | 183-2 v Leyton OrientLeyton Orient 2-3 Oxford United | Sky Bet League One |
| 18 | Sat 25 Nov | 180-2 v Cheltenham TownCheltenham Town 2-0 Oxford United | Sky Bet League One |
| 19 | Tue 28 Nov | 180-0 v Bolton WanderersOxford United 0-0 Bolton Wanderers | Sky Bet League One |
| 20 | Sat 2 Dec | 182-0 v Grimsby TownOxford United 2-0 Grimsby Town | Emirates FA Cup Second Round |
| 21 | Sat 9 Dec | 180-3 v Peterborough UnitedPeterborough United 3-0 Oxford United | Sky Bet League One |
| 22 | Tue 12 Dec | 181-1 v ReadingReading 1-1 Oxford United | Sky Bet League One |
| 23 | Sat 16 Dec | 183-0 v Burton AlbionOxford United 3-0 Burton Albion | Sky Bet League One |
| 24 | Sat 23 Dec | 181-2 v Northampton TownNorthampton Town 2-1 Oxford United | Sky Bet League One |
| 25 | Tue 26 Dec | 182-1 v Cambridge UnitedOxford United 2-1 Cambridge United | Sky Bet League One |
| 26 | Fri 29 Dec | 182-3 v Derby CountyOxford United 2-3 Derby County | Sky Bet League One |
| 27 | Mon 1 Jan | 18 2-1 v Charlton AthleticCharlton Athletic 1-2 Oxford United | Sky Bet League One |
| 28 | Sat 6 Jan | 182-6 v Coventry CityCoventry City 6-2 Oxford United | Emirates FA Cup Third Round |
| 29 | Tue 9 Jan | 180-2 v AFC WimbledonAFC Wimbledon 2-0 Oxford United | EFL Trophy Third Round |
| 30 | Sat 13 Jan | 183-1 v Carlisle UnitedCarlisle United 1-3 Oxford United | Sky Bet League One |
| 31 | Tue 23 Jan | 180-1 v BarnsleyOxford United 0-1 Barnsley | Sky Bet League One |
| 32 | Sat 27 Jan | 181-3 v Bristol RoversBristol Rovers 3-1 Oxford United | Sky Bet League One |
| 33 | Tue 30 Jan | 182-2 v PortsmouthOxford United 2-2 Portsmouth | Sky Bet League One |
| 34 | Sat 3 Feb | 181-1 v ReadingOxford United 1-1 Reading | Sky Bet League One |
| 35 | Sat 10 Feb | 181-1 v BlackpoolBlackpool 1-1 Oxford United | Sky Bet League One |
| 36 | Tue 13 Feb | 184-2 v Wigan AthleticOxford United 4-2 Wigan Athletic | Sky Bet League One |
| 37 | Sat 24 Feb | 181-2 v Leyton OrientOxford United 1-2 Leyton Orient | Sky Bet League One |
| 38 | Sat 2 Mar | 181-2 v PortsmouthPortsmouth 2-1 Oxford United | Sky Bet League One |
| 39 | Sat 9 Mar | 182-1 v Cheltenham TownOxford United 2-1 Cheltenham Town | Sky Bet League One |
| 40 | Tue 12 Mar | 180-5 v Bolton WanderersBolton Wanderers 5-0 Oxford United | Sky Bet League One |
| 41 | Sat 13 Apr | 185-0 v Peterborough UnitedOxford United 5-0 Peterborough United | Sky Bet League One |
| 42 | Tue 16 Apr | 18 0-1 v Lincoln CityOxford United 0-1 Lincoln City | Sky Bet League One |
| 43 | Sat 27 Apr | 182-1 v Exeter CityExeter City 1-2 Oxford United | Sky Bet League One |
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