| 1 | Sat 5 Aug | 10-2 v Cambridge UnitedCambridge United 2-0 Oxford United | Sky Bet League One |
| 2 | Wed 9 Aug | 11-5 v Bristol CityBristol City 5-1 Oxford United | Carabao Cup First Round South |
| 3 | Tue 15 Aug | 1 2-1 v Derby CountyDerby County 1-2 Oxford United | Sky Bet League One |
| 4 | Sat 19 Aug | 13-1 v BarnsleyBarnsley 1-3 Oxford United | Sky Bet League One |
| 5 | Sat 26 Aug | 12-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 6 | Sat 2 Sep | 11-2 v Port ValeOxford United 1-2 Port Vale | Sky Bet League One |
| 7 | Sat 16 Sep | 13-0 v Fleetwood TownFleetwood Town 0-3 Oxford United | Sky Bet League One |
| 8 | Sat 23 Sep | 13-0 v Exeter CityOxford United 3-0 Exeter City | Sky Bet League One |
| 9 | Sat 30 Sep | 1 3-1 v StevenageStevenage 1-3 Oxford United | Sky Bet League One |
| 10 | Tue 3 Oct | 13-0 v Shrewsbury TownOxford United 3-0 Shrewsbury Town | Sky Bet League One |
| 11 | Sat 7 Oct | 12-1 v Bristol RoversOxford United 2-1 Bristol Rovers | Sky Bet League One |
| 12 | Sat 21 Oct | 11-1 v BlackpoolOxford United 1-1 Blackpool | Sky Bet League One |
| 13 | Tue 24 Oct | 1 0-2 v Wigan AthleticWigan Athletic 2-0 Oxford United | Sky Bet League One |
| 14 | Sat 28 Oct | 12-2 v Wycombe WanderersOxford United 2-2 Wycombe Wanderers | Sky Bet League One |
| 15 | Tue 31 Oct | 12-0 v Lincoln CityLincoln City 0-2 Oxford United | Sky Bet League One |
| 16 | Sat 11 Nov | 13-2 v Leyton OrientLeyton Orient 2-3 Oxford United | Sky Bet League One |
| 17 | Sat 25 Nov | 10-2 v Cheltenham TownCheltenham Town 2-0 Oxford United | Sky Bet League One |
| 18 | Tue 28 Nov | 10-0 v Bolton WanderersOxford United 0-0 Bolton Wanderers | Sky Bet League One |
| 19 | Sat 2 Dec | 12-0 v Grimsby TownOxford United 2-0 Grimsby Town | Emirates FA Cup Second Round |
| 20 | Sat 9 Dec | 10-3 v Peterborough UnitedPeterborough United 3-0 Oxford United | Sky Bet League One |
| 21 | Tue 12 Dec | 11-1 v ReadingReading 1-1 Oxford United | Sky Bet League One |
| 22 | Sat 16 Dec | 13-0 v Burton AlbionOxford United 3-0 Burton Albion | Sky Bet League One |
| 23 | Sat 23 Dec | 11-2 v Northampton TownNorthampton Town 2-1 Oxford United | Sky Bet League One |
| 24 | Tue 26 Dec | 12-1 v Cambridge UnitedOxford United 2-1 Cambridge United | Sky Bet League One |
| 25 | Fri 29 Dec | 1 2-3 v Derby CountyOxford United 2-3 Derby County | Sky Bet League One |
| 26 | Mon 1 Jan | 12-1 v Charlton AthleticCharlton Athletic 1-2 Oxford United | Sky Bet League One |
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