| 1 | 7/8/2021 | 200-2 v Rotherham UnitedRotherham United 2-0 Plymouth Argyle | Sky Bet League One |
| 2 | 10/8/2021 | 204-0 v Peterborough UnitedPeterborough United 0-4 Plymouth Argyle | Carabao Cup First Round |
| 3 | 14/8/2021 | 201-0 v GillinghamPlymouth Argyle 1-0 Gillingham | Sky Bet League One |
| 4 | 17/8/2021 | 201-1 v Cambridge UnitedPlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 5 | 21/8/2021 | 203-0 v Shrewsbury TownShrewsbury Town 0-3 Plymouth Argyle | Sky Bet League One |
| 6 | 24/8/2021 | 201-4 v Swansea CitySwansea City 4-1 Plymouth Argyle | Carabao Cup Second Round |
| 7 | 28/8/2021 | 201-1 v Fleetwood TownPlymouth Argyle 1-1 Fleetwood Town | Sky Bet League One |
| 8 | 31/8/2021 | 20 0-2 v Newport CountyNewport County 2-0 Plymouth Argyle | Checkatrade Trophy |
| 9 | 11/9/2021 | 203-0 v Sheffield WednesdayPlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 10 | 18/9/2021 | 201-0 v AFC WimbledonAFC Wimbledon 0-1 Plymouth Argyle | Sky Bet League One |
| 11 | 21/9/2021 | 202-2 v PortsmouthPortsmouth 2-2 Plymouth Argyle | Sky Bet League One |
| 12 | 25/9/2021 | 202-1 v Doncaster RoversPlymouth Argyle 2-1 Doncaster Rovers | Sky Bet League One |
| 13 | 28/9/2021 | 201-1 v Crewe AlexandraPlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 14 | 2/10/2021 | 202-2 v Lincoln CityLincoln City 2-2 Plymouth Argyle | Sky Bet League One |
| 15 | 9/10/2021 | 202-1 v Burton AlbionPlymouth Argyle 2-1 Burton Albion | Sky Bet League One |
| 16 | 12/10/2021 | 201-3 v Swindon TownPlymouth Argyle 1-3 Swindon Town | Checkatrade Trophy |
| 17 | 19/10/2021 | 203-0 v Bolton WanderersPlymouth Argyle 3-0 Bolton Wanderers | Sky Bet League One |
| 18 | 23/10/2021 | 201-1 v MorecambeMorecambe 1-1 Plymouth Argyle | Sky Bet League One |
| 19 | 30/10/2021 | 202-1 v Ipswich TownPlymouth Argyle 2-1 Ipswich Town | Sky Bet League One |
| 20 | 7/11/2021 | 200-0 v Sheffield WednesdaySheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 21 | 13/11/2021 | 204-1 v Accrington StanleyAccrington Stanley 1-4 Plymouth Argyle | Sky Bet League One |
| 22 | 16/11/2021 | 203-0 v Sheffield WednesdayPlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup |
| 23 | 20/11/2021 | 200-2 v Charlton AthleticCharlton Athletic 2-0 Plymouth Argyle | Sky Bet League One |
| 24 | 23/11/2021 | 200-3 v Wycombe WanderersPlymouth Argyle 0-3 Wycombe Wanderers | Sky Bet League One |
| 25 | 27/11/2021 | 201-2 v Wigan AthleticPlymouth Argyle 1-2 Wigan Athletic | Sky Bet League One |
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