| 1 | Sat 5 Aug | 23-1 v Huddersfield TownPlymouth Argyle 3-1 Huddersfield Town | Sky Bet Championship |
| 2 | Sat 12 Aug | 2 0-0 v WatfordWatford 0-0 Plymouth Argyle | Sky Bet Championship |
| 3 | Sat 19 Aug | 21-2 v SouthamptonPlymouth Argyle 1-2 Southampton | Sky Bet Championship |
| 4 | Sat 26 Aug | 21-2 v Birmingham CityBirmingham City 2-1 Plymouth Argyle | Sky Bet Championship |
| 5 | Tue 29 Aug | 22-4 v Crystal PalacePlymouth Argyle 2-4 Crystal Palace | Carabao Cup Second Round |
| 6 | Sat 2 Sep | 23-0 v Blackburn RoversPlymouth Argyle 3-0 Blackburn Rovers | Sky Bet Championship |
| 7 | Sat 16 Sep | 21-2 v Preston North EndPreston North End 2-1 Plymouth Argyle | Sky Bet Championship |
| 8 | Tue 19 Sep | 21-4 v Bristol CityBristol City 4-1 Plymouth Argyle | Sky Bet Championship |
| 9 | Sat 23 Sep | 26-2 v Norwich CityPlymouth Argyle 6-2 Norwich City | Sky Bet Championship |
| 10 | Sat 30 Sep | 21-1 v Hull CityHull City 1-1 Plymouth Argyle | Sky Bet Championship |
| 11 | Tue 3 Oct | 20-2 v MillwallPlymouth Argyle 0-2 Millwall | Sky Bet Championship |
| 12 | Sat 7 Oct | 21-3 v Swansea CityPlymouth Argyle 1-3 Swansea City | Sky Bet Championship |
| 13 | Sat 21 Oct | 2 0-0 v West Bromwich AlbionWest Bromwich Albion 0-0 Plymouth Argyle | Sky Bet Championship |
| 14 | Wed 25 Oct | 23-0 v Sheffield WednesdayPlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet Championship |
| 15 | Sat 28 Oct | 2 2-3 v Ipswich TownIpswich Town 3-2 Plymouth Argyle | Sky Bet Championship |
| 16 | Sat 4 Nov | 23-3 v MiddlesbroughPlymouth Argyle 3-3 Middlesbrough | Sky Bet Championship |
| 17 | Sat 11 Nov | 21-2 v Leeds UnitedLeeds United 2-1 Plymouth Argyle | Sky Bet Championship |
| 18 | Sat 25 Nov | 2 2-0 v SunderlandPlymouth Argyle 2-0 Sunderland | Sky Bet Championship |
| 19 | Tue 28 Nov | 20-1 v Coventry CityCoventry City 1-0 Plymouth Argyle | Sky Bet Championship |
| 20 | Sat 2 Dec | 22-1 v Stoke CityPlymouth Argyle 2-1 Stoke City | Sky Bet Championship |
| 21 | Sat 9 Dec | 20-4 v Leicester CityLeicester City 4-0 Plymouth Argyle | Sky Bet Championship |
| 22 | Wed 13 Dec | 20-0 v Queens Park RangersQueens Park Rangers 0-0 Plymouth Argyle | Sky Bet Championship |
| 23 | Sat 16 Dec | 23-2 v Rotherham UnitedPlymouth Argyle 3-2 Rotherham United | Sky Bet Championship |
| 24 | Sat 23 Dec | 23-3 v Birmingham CityPlymouth Argyle 3-3 Birmingham City | Sky Bet Championship |
| 25 | Tue 26 Dec | 22-2 v Cardiff CityCardiff City 2-2 Plymouth Argyle | Sky Bet Championship |
| 26 | Fri 29 Dec | 2 1-2 v SouthamptonSouthampton 2-1 Plymouth Argyle | Sky Bet Championship |
| 27 | Mon 1 Jan | 2 3-3 v WatfordPlymouth Argyle 3-3 Watford | Sky Bet Championship |
| 28 | Sat 6 Jan | 23-1 v Sutton UnitedPlymouth Argyle 3-1 Sutton United | Emirates FA Cup Third Round |
| 29 | Sat 13 Jan | 21-1 v Huddersfield TownHuddersfield Town 1-1 Plymouth Argyle | Sky Bet Championship |
| 30 | Sat 20 Jan | 2 3-1 v Cardiff CityPlymouth Argyle 3-1 Cardiff City | Sky Bet Championship |
| 31 | Sat 27 Jan | 21-1 v Leeds UnitedLeeds United 1-1 Plymouth Argyle | Emirates FA Cup Fourth Round |
| 32 | Sat 3 Feb | 21-0 v Swansea CitySwansea City 0-1 Plymouth Argyle | Sky Bet Championship |
| 33 | Tue 6 Feb | 21-4 v Leeds UnitedPlymouth Argyle 1-4 Leeds United | Emirates FA Cup Fourth Round Replay |
| 34 | Sat 10 Feb | 2 1-3 v SunderlandSunderland 3-1 Plymouth Argyle | Sky Bet Championship |
| 35 | Wed 14 Feb | 22-2 v Coventry CityPlymouth Argyle 2-2 Coventry City | Sky Bet Championship |
| 36 | Sat 17 Feb | 20-2 v Leeds UnitedPlymouth Argyle 0-2 Leeds United | Sky Bet Championship |
| 37 | Tue 20 Feb | 2 0-3 v West Bromwich AlbionPlymouth Argyle 0-3 West Bromwich Albion | Sky Bet Championship |
| 38 | Sat 24 Feb | 22-0 v MiddlesbroughMiddlesbrough 0-2 Plymouth Argyle | Sky Bet Championship |
| 39 | Tue 5 Mar | 20-1 v Sheffield WednesdaySheffield Wednesday 1-0 Plymouth Argyle | Sky Bet Championship |
| 40 | Sat 9 Mar | 2 1-1 v Blackburn RoversBlackburn Rovers 1-1 Plymouth Argyle | Sky Bet Championship |
| 41 | Mon 1 Apr | 20-1 v Bristol CityPlymouth Argyle 0-1 Bristol City | Sky Bet Championship |
| 42 | Fri 5 Apr | 21-0 v Rotherham UnitedRotherham United 0-1 Plymouth Argyle | Sky Bet Championship |
| 43 | Tue 9 Apr | 21-1 v Queens Park RangersPlymouth Argyle 1-1 Queens Park Rangers | Sky Bet Championship |
| 44 | Fri 12 Apr | 21-0 v Leicester CityPlymouth Argyle 1-0 Leicester City | Sky Bet Championship |
| 45 | Sat 20 Apr | 2 0-3 v Stoke CityStoke City 3-0 Plymouth Argyle | Sky Bet Championship |
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