| 1 | Sat 14 Aug 2021 | 210-0 v Tranmere RoversPort Vale 0-0 Tranmere Rovers | Sky Bet League Two |
| 2 | Tue 17 Aug 2021 | 210-0 v Carlisle UnitedPort Vale 0-0 Carlisle United | Sky Bet League Two |
| 3 | Sat 21 Aug 2021 | 211-1 v StevenageStevenage 1-1 Port Vale | Sky Bet League Two |
| 4 | Sat 28 Aug 2021 | 21 2-0 v Forest Green RoversForest Green Rovers 0-2 Port Vale | Sky Bet League Two |
| 5 | Tue 31 Aug 2021 | 212-3 v Bolton WanderersBolton Wanderers 3-2 Port Vale | Papa John’s Trophy |
| 6 | Sat 4 Sep 2021 | 212-3 v RochdalePort Vale 2-3 Rochdale | Sky Bet League Two |
| 7 | Sat 11 Sep 2021 | 212-1 v Swindon TownSwindon Town 1-2 Port Vale | Sky Bet League Two |
| 8 | Tue 19 Oct 2021 | 211-1 v Mansfield TownMansfield Town 1-1 Port Vale | Sky Bet League Two |
| 9 | Sat 23 Oct 2021 | 213-0 v Colchester UnitedPort Vale 3-0 Colchester United | Sky Bet League Two |
| 10 | Sat 13 Nov 2021 | 211-1 v Bradford CityPort Vale 1-1 Bradford City | Sky Bet League Two |
| 11 | Sat 20 Nov 2021 | 212-3 v Oldham AthleticOldham Athletic 3-2 Port Vale | Sky Bet League Two |
| 12 | Tue 23 Nov 2021 | 210-1 v WalsallPort Vale 0-1 Walsall | Sky Bet League Two |
| 13 | Sat 27 Nov 2021 | 212-0 v Hartlepool UnitedPort Vale 2-0 Hartlepool United | Sky Bet League Two |
| 14 | Sat 4 Dec 2021 | 212-1 v Burton AlbionBurton Albion 1-2 Port Vale | Emirates FA Cup Second Round |
| 15 | Tue 7 Dec 2021 | 212-1 v Bristol RoversBristol Rovers 1-2 Port Vale | Sky Bet League Two |
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