| 1 | Thu 4 Feb 2021 | 880-2 v MoreirenseFamalicão 0-2 Moreirense |
| 2 | Mon 8 Feb 2021 | 880-2 v BenficaBenfica 2-0 Famalicão |
| 3 | Fri 12 Feb 2021 | 88 0-0 v BelenensesFamalicão 0-0 Belenenses |
| 4 | Sun 21 Feb 2021 | 881-0 v Rio AveRio Ave 0-1 Famalicão |
| 5 | Sat 27 Feb 2021 | 880-0 v FarenseFamalicão 0-0 Farense |
| 6 | Sat 6 Mar 2021 | 88 0-3 v BoavistaBoavista 3-0 Famalicão |
| 7 | Mon 15 Mar 2021 | 882-2 v Sporting BragaFamalicão 2-2 Sporting Braga |
| 8 | Sun 21 Mar 2021 | 884-0 v MarítimoMarítimo 0-4 Famalicão |
| 9 | Sun 4 Apr 2021 | 882-0 v Paços de FerreiraFamalicão 2-0 Paços de Ferreira |
| 10 | Sun 11 Apr 2021 | 881-1 v Sporting LisbonSporting Lisbon 1-1 Famalicão |
| 11 | Sun 18 Apr 2021 | 880-1 v PortimonenseFamalicão 0-1 Portimonense |
| 12 | Thu 22 Apr 2021 | 88 3-0 v Gil VicenteGil Vicente 0-3 Famalicão |
| 13 | Mon 26 Apr 2021 | 882-2 v TondelaFamalicão 2-2 Tondela |
| 14 | Fri 30 Apr 2021 | 882-3 v FC PortoFC Porto 3-2 Famalicão |
| 15 | Fri 7 May 2021 | 881-0 v Santa ClaraFamalicão 1-0 Santa Clara |
| 16 | Wed 12 May 2021 | 882-1 v Vitória GuimarãesVitória Guimarães 1-2 Famalicão |
| 17 | Sun 16 May 2021 | 883-0 v NacionalFamalicão 3-0 Nacional |
| 18 | Wed 19 May 2021 | 88 0-3 v MoreirenseMoreirense 3-0 Famalicão |
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