| 1 | Sun 8 Aug 2021 | 771-0 v Vitória GuimarãesVitória Guimarães 0-1 Portimonense |
| 2 | Sun 15 Aug 2021 | 770-1 v Gil VicentePortimonense 0-1 Gil Vicente |
| 3 | Sun 22 Aug 2021 | 773-0 v TondelaTondela 0-3 Portimonense |
| 4 | Sun 29 Aug 2021 | 770-1 v Paços de FerreiraPortimonense 0-1 Paços de Ferreira |
| 5 | Sun 12 Sep 2021 | 771-1 v BoavistaBoavista 1-1 Portimonense |
| 6 | Fri 17 Sep 2021 | 772-1 v Santa ClaraPortimonense 2-1 Santa Clara |
| 7 | Sun 26 Sep 2021 | 770-0 v VizelaPortimonense 0-0 Vizela |
| 8 | Sun 3 Oct 2021 | 77 1-0 v BenficaBenfica 0-1 Portimonense |
| 9 | Sun 24 Oct 2021 | 770-2 v Estoril PraiaPortimonense 0-2 Estoril Praia |
| 10 | Mon 1 Nov 2021 | 770-3 v Sporting BragaSporting Braga 3-0 Portimonense |
| 11 | Sat 6 Nov 2021 | 77 2-0 v BelenensesPortimonense 2-0 Belenenses |
| 12 | Sat 27 Nov 2021 | 773-0 v FamalicãoFamalicão 0-3 Portimonense |
| 13 | Fri 3 Dec 2021 | 770-3 v FC PortoPortimonense 0-3 FC Porto |
| 14 | Sun 12 Dec 2021 | 771-0 v MoreirenseMoreirense 0-1 Portimonense |
| 15 | Sat 18 Dec 2021 | 771-1 v AroucaPortimonense 1-1 Arouca |
| 16 | Sun 9 Jan 2022 | 771-2 v MarítimoPortimonense 1-2 Marítimo |
| 17 | Mon 17 Jan 2022 | 771-1 v Vitória GuimarãesPortimonense 1-1 Vitória Guimarães |
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