| 1 | Sun 8 Aug 2021 | 201-0 v Vitória GuimarãesVitória Guimarães 0-1 Portimonense |
| 2 | Sun 15 Aug 2021 | 200-1 v Gil VicentePortimonense 0-1 Gil Vicente |
| 3 | Sun 22 Aug 2021 | 203-0 v TondelaTondela 0-3 Portimonense |
| 4 | Sun 29 Aug 2021 | 200-1 v Paços de FerreiraPortimonense 0-1 Paços de Ferreira |
| 5 | Sun 12 Sep 2021 | 201-1 v BoavistaBoavista 1-1 Portimonense |
| 6 | Sun 26 Sep 2021 | 200-0 v VizelaPortimonense 0-0 Vizela |
| 7 | Sat 6 Nov 2021 | 202-0 v BelenensesPortimonense 2-0 Belenenses |
| 8 | Fri 3 Dec 2021 | 20 0-3 v FC PortoPortimonense 0-3 FC Porto |
| 9 | Sat 18 Dec 2021 | 201-1 v AroucaPortimonense 1-1 Arouca |
| 10 | Wed 29 Dec 2021 | 202-3 v Sporting LisbonSporting Lisbon 3-2 Portimonense |
| 11 | Sun 9 Jan 2022 | 201-2 v MarítimoPortimonense 1-2 Marítimo |
| 12 | Sat 5 Feb 2022 | 20 1-1 v Paços de FerreiraPaços de Ferreira 1-1 Portimonense |
| 13 | Sat 5 Mar 2022 | 20 1-2 v BenficaPortimonense 1-2 Benfica |
| 14 | Sat 12 Mar 2022 | 200-2 v Estoril PraiaEstoril Praia 2-0 Portimonense |
| 15 | Sun 20 Mar 2022 | 201-2 v Sporting BragaPortimonense 1-2 Sporting Braga |
| 16 | Sun 10 Apr 2022 | 20 1-0 v FamalicãoPortimonense 1-0 Famalicão |
| 17 | Sat 23 Apr 2022 | 201-0 v MoreirensePortimonense 1-0 Moreirense |
| 18 | Sat 30 Apr 2022 | 200-1 v AroucaArouca 1-0 Portimonense |
| 19 | Sat 7 May 2022 | 202-3 v Sporting LisbonPortimonense 2-3 Sporting Lisbon |
| 20 | Sat 14 May 2022 | 201-0 v MarítimoMarítimo 0-1 Portimonense |
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