| 1 | Sun 8 Aug 2021 | 211-0 v Vitória GuimarãesVitória Guimarães 0-1 Portimonense |
| 2 | Sun 15 Aug 2021 | 210-1 v Gil VicentePortimonense 0-1 Gil Vicente |
| 3 | Sun 22 Aug 2021 | 213-0 v TondelaTondela 0-3 Portimonense |
| 4 | Fri 17 Sep 2021 | 212-1 v Santa ClaraPortimonense 2-1 Santa Clara |
| 5 | Sun 3 Oct 2021 | 211-0 v BenficaBenfica 0-1 Portimonense |
| 6 | Sun 24 Oct 2021 | 210-2 v Estoril PraiaPortimonense 0-2 Estoril Praia |
| 7 | Mon 1 Nov 2021 | 21 0-3 v Sporting BragaSporting Braga 3-0 Portimonense |
| 8 | Sat 6 Nov 2021 | 212-0 v BelenensesPortimonense 2-0 Belenenses |
| 9 | Sat 27 Nov 2021 | 21 3-0 v FamalicãoFamalicão 0-3 Portimonense |
| 10 | Fri 3 Dec 2021 | 210-3 v FC PortoPortimonense 0-3 FC Porto |
| 11 | Sun 12 Dec 2021 | 211-0 v MoreirenseMoreirense 0-1 Portimonense |
| 12 | Sat 18 Dec 2021 | 211-1 v AroucaPortimonense 1-1 Arouca |
| 13 | Wed 29 Dec 2021 | 21 2-3 v Sporting LisbonSporting Lisbon 3-2 Portimonense |
| 14 | Sun 23 Jan 2022 | 210-1 v Gil VicenteGil Vicente 1-0 Portimonense |
| 15 | Sat 12 Mar 2022 | 21 0-2 v Estoril PraiaEstoril Praia 2-0 Portimonense |
| 16 | Sun 10 Apr 2022 | 211-0 v FamalicãoPortimonense 1-0 Famalicão |
| 17 | Sat 16 Apr 2022 | 210-7 v FC PortoFC Porto 7-0 Portimonense |
| 18 | Sat 23 Apr 2022 | 211-0 v MoreirensePortimonense 1-0 Moreirense |
| 19 | Sat 30 Apr 2022 | 210-1 v AroucaArouca 1-0 Portimonense |
| 20 | Sat 14 May 2022 | 211-0 v MarítimoMarítimo 0-1 Portimonense |
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