| 1 | Sun 12 Sep 2021 | 39 1-1 v BoavistaBoavista 1-1 Portimonense |
| 2 | Fri 17 Sep 2021 | 39 2-1 v Santa ClaraPortimonense 2-1 Santa Clara |
| 3 | Sun 26 Sep 2021 | 390-0 v VizelaPortimonense 0-0 Vizela |
| 4 | Sun 3 Oct 2021 | 391-0 v BenficaBenfica 0-1 Portimonense |
| 5 | Sun 24 Oct 2021 | 390-2 v Estoril PraiaPortimonense 0-2 Estoril Praia |
| 6 | Mon 1 Nov 2021 | 39 0-3 v Sporting BragaSporting Braga 3-0 Portimonense |
| 7 | Sat 6 Nov 2021 | 392-0 v BelenensesPortimonense 2-0 Belenenses |
| 8 | Sat 27 Nov 2021 | 393-0 v FamalicãoFamalicão 0-3 Portimonense |
| 9 | Sun 12 Dec 2021 | 391-0 v MoreirenseMoreirense 0-1 Portimonense |
| 10 | Sat 18 Dec 2021 | 391-1 v AroucaPortimonense 1-1 Arouca |
| 11 | Mon 17 Jan 2022 | 391-1 v Vitória GuimarãesPortimonense 1-1 Vitória Guimarães |
| 12 | Sun 23 Jan 2022 | 390-1 v Gil VicenteGil Vicente 1-0 Portimonense |
| 13 | Sun 30 Jan 2022 | 391-2 v TondelaPortimonense 1-2 Tondela |
| 14 | Sat 12 Mar 2022 | 390-2 v Estoril PraiaEstoril Praia 2-0 Portimonense |
| 15 | Sun 20 Mar 2022 | 391-2 v Sporting BragaPortimonense 1-2 Sporting Braga |
| 16 | Sat 2 Apr 2022 | 390-2 v BelenensesBelenenses 2-0 Portimonense |
| 17 | Sun 10 Apr 2022 | 391-0 v FamalicãoPortimonense 1-0 Famalicão |
| 18 | Sat 16 Apr 2022 | 39 0-7 v FC PortoFC Porto 7-0 Portimonense |
| 19 | Sat 23 Apr 2022 | 391-0 v MoreirensePortimonense 1-0 Moreirense |
| 20 | Sat 30 Apr 2022 | 390-1 v AroucaArouca 1-0 Portimonense |
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