| 1 | Sat 22 Sep 2018 | 350-3 v LiverpoolLiverpool 3-0 Southampton |
| 2 | Sun 7 Oct 2018 | 350-3 v ChelseaSouthampton 0-3 Chelsea |
| 3 | Sat 8 Dec 2018 | 350-1 v Cardiff CityCardiff City 1-0 Southampton |
| 4 | Sun 16 Dec 2018 | 35 3-2 v ArsenalSouthampton 3-2 Arsenal |
| 5 | Sat 22 Dec 2018 | 353-1 v Huddersfield TownHuddersfield Town 1-3 Southampton |
| 6 | Thu 27 Dec 2018 | 35 1-2 v West Ham UnitedSouthampton 1-2 West Ham United |
| 7 | Sun 30 Dec 2018 | 35 1-3 v Manchester CitySouthampton 1-3 Manchester City |
| 8 | Wed 2 Jan 2019 | 35 0-0 v ChelseaChelsea 0-0 Southampton |
| 9 | Sat 12 Jan 2019 | 352-1 v Leicester CityLeicester City 1-2 Southampton |
| 10 | Sat 19 Jan 2019 | 352-1 v EvertonSouthampton 2-1 Everton |
| 11 | Wed 30 Jan 2019 | 35 1-1 v Crystal PalaceSouthampton 1-1 Crystal Palace |
| 12 | Sat 2 Feb 2019 | 351-1 v BurnleyBurnley 1-1 Southampton |
| 13 | Sat 9 Feb 2019 | 351-2 v Cardiff CitySouthampton 1-2 Cardiff City |
| 14 | Sun 24 Feb 2019 | 350-2 v ArsenalArsenal 2-0 Southampton |
| 15 | Wed 27 Feb 2019 | 352-0 v FulhamSouthampton 2-0 Fulham |
| 16 | Sat 2 Mar 2019 | 352-3 v Manchester UnitedManchester United 3-2 Southampton |
| 17 | Sat 9 Mar 2019 | 352-1 v Tottenham HotspurSouthampton 2-1 Tottenham Hotspur |
| 18 | Sat 30 Mar 2019 | 35 1-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-1 Southampton |
| 19 | Fri 5 Apr 2019 | 35 1-3 v LiverpoolSouthampton 1-3 Liverpool |
| 20 | Sat 13 Apr 2019 | 353-1 v Wolverhampton WanderersSouthampton 3-1 Wolverhampton Wanderers |
| 21 | Sat 20 Apr 2019 | 351-3 v Newcastle UnitedNewcastle United 3-1 Southampton |
| 22 | Tue 23 Apr 2019 | 35 1-1 v WatfordWatford 1-1 Southampton |
| 23 | Sat 27 Apr 2019 | 353-3 v AFC BournemouthSouthampton 3-3 AFC Bournemouth |
| 24 | Sat 4 May 2019 | 350-3 v West Ham UnitedWest Ham United 3-0 Southampton |
| 25 | Sun 12 May 2019 | 351-1 v Huddersfield TownSouthampton 1-1 Huddersfield Town |
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