| 1 | Sun 12 Aug 2018 | 10-4 v LiverpoolLiverpool 4-0 West Ham United |
| 2 | Sat 18 Aug 2018 | 11-2 v AFC BournemouthWest Ham United 1-2 AFC Bournemouth |
| 3 | Sat 25 Aug 2018 | 11-3 v ArsenalArsenal 3-1 West Ham United |
| 4 | Sat 1 Sep 2018 | 10-1 v Wolverhampton WanderersWest Ham United 0-1 Wolverhampton Wanderers |
| 5 | Sun 16 Sep 2018 | 13-1 v EvertonEverton 1-3 West Ham United |
| 6 | Sun 23 Sep 2018 | 10-0 v ChelseaWest Ham United 0-0 Chelsea |
| 7 | Sat 29 Sep 2018 | 13-1 v Manchester UnitedWest Ham United 3-1 Manchester United |
| 8 | Fri 5 Oct 2018 | 10-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-0 West Ham United |
| 9 | Sat 20 Oct 2018 | 10-1 v Tottenham HotspurWest Ham United 0-1 Tottenham Hotspur |
| 10 | Sat 27 Oct 2018 | 11-1 v Leicester CityLeicester City 1-1 West Ham United |
| 11 | Sat 3 Nov 2018 | 14-2 v BurnleyWest Ham United 4-2 Burnley |
| 12 | Sat 10 Nov 2018 | 11-1 v Huddersfield TownHuddersfield Town 1-1 West Ham United |
| 13 | Sat 24 Nov 2018 | 10-4 v Manchester CityWest Ham United 0-4 Manchester City |
| 14 | Sat 1 Dec 2018 | 13-0 v Newcastle UnitedNewcastle United 0-3 West Ham United |
| 15 | Tue 4 Dec 2018 | 13-1 v Cardiff CityWest Ham United 3-1 Cardiff City |
| 16 | Sat 8 Dec 2018 | 13-2 v Crystal PalaceWest Ham United 3-2 Crystal Palace |
| 17 | Sat 15 Dec 2018 | 12-0 v FulhamFulham 0-2 West Ham United |
| 18 | Sat 22 Dec 2018 | 10-2 v WatfordWest Ham United 0-2 Watford |
| 19 | Thu 27 Dec 2018 | 12-1 v SouthamptonSouthampton 1-2 West Ham United |
| 20 | Sun 30 Dec 2018 | 10-2 v BurnleyBurnley 2-0 West Ham United |
| 21 | Wed 2 Jan 2019 | 12-2 v Brighton & Hove AlbionWest Ham United 2-2 Brighton & Hove Albion |
| 22 | Sat 12 Jan 2019 | 11-0 v ArsenalWest Ham United 1-0 Arsenal |
| 23 | Sat 19 Jan 2019 | 10-2 v AFC BournemouthAFC Bournemouth 2-0 West Ham United |
| 24 | Tue 29 Jan 2019 | 10-3 v Wolverhampton WanderersWolverhampton Wanderers 3-0 West Ham United |
| 25 | Mon 4 Feb 2019 | 11-1 v LiverpoolWest Ham United 1-1 Liverpool |
| 26 | Sat 9 Feb 2019 | 11-1 v Crystal PalaceCrystal Palace 1-1 West Ham United |
| 27 | Fri 22 Feb 2019 | 13-1 v FulhamWest Ham United 3-1 Fulham |
| 28 | Wed 27 Feb 2019 | 10-1 v Manchester CityManchester City 1-0 West Ham United |
| 29 | Sat 2 Mar 2019 | 12-0 v Newcastle UnitedWest Ham United 2-0 Newcastle United |
| 30 | Sat 9 Mar 2019 | 10-2 v Cardiff CityCardiff City 2-0 West Ham United |
| 31 | Sat 16 Mar 2019 | 14-3 v Huddersfield TownWest Ham United 4-3 Huddersfield Town |
| 32 | Sat 30 Mar 2019 | 10-2 v EvertonWest Ham United 0-2 Everton |
| 33 | Mon 8 Apr 2019 | 10-2 v ChelseaChelsea 2-0 West Ham United |
| 34 | Sat 13 Apr 2019 | 11-2 v Manchester UnitedManchester United 2-1 West Ham United |
| 35 | Sat 20 Apr 2019 | 12-2 v Leicester CityWest Ham United 2-2 Leicester City |
| 36 | Sat 27 Apr 2019 | 11-0 v Tottenham HotspurTottenham Hotspur 0-1 West Ham United |
| 37 | Sat 4 May 2019 | 13-0 v SouthamptonWest Ham United 3-0 Southampton |
| 38 | Sun 12 May 2019 | 14-1 v WatfordWatford 1-4 West Ham United |
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