| 1 | Sat 10 Aug 2019 | 230-3 v BurnleyBurnley 3-0 Southampton |
| 2 | Sat 17 Aug 2019 | 231-2 v LiverpoolSouthampton 1-2 Liverpool |
| 3 | Sat 24 Aug 2019 | 23 2-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Southampton |
| 4 | Sat 31 Aug 2019 | 231-1 v Manchester UnitedSouthampton 1-1 Manchester United |
| 5 | Sat 14 Sep 2019 | 231-0 v Sheffield UnitedSheffield United 0-1 Southampton |
| 6 | Fri 20 Sep 2019 | 231-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth |
| 7 | Sat 28 Sep 2019 | 231-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton |
| 8 | Sun 6 Oct 2019 | 231-4 v ChelseaSouthampton 1-4 Chelsea |
| 9 | Sat 19 Oct 2019 | 231-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton |
| 10 | Fri 25 Oct 2019 | 230-9 v Leicester CitySouthampton 0-9 Leicester City |
| 11 | Sat 2 Nov 2019 | 23 1-2 v Manchester CityManchester City 2-1 Southampton |
| 12 | Sat 23 Nov 2019 | 232-2 v ArsenalArsenal 2-2 Southampton |
| 13 | Sat 30 Nov 2019 | 232-1 v WatfordSouthampton 2-1 Watford |
| 14 | Wed 4 Dec 2019 | 232-1 v Norwich CitySouthampton 2-1 Norwich City |
| 15 | Sun 8 Dec 2019 | 23 1-2 v Newcastle UnitedNewcastle United 2-1 Southampton |
| 16 | Sat 14 Dec 2019 | 23 0-1 v West Ham UnitedSouthampton 0-1 West Ham United |
| 17 | Sat 21 Dec 2019 | 233-1 v Aston VillaAston Villa 1-3 Southampton |
| 18 | Thu 26 Dec 2019 | 232-0 v ChelseaChelsea 0-2 Southampton |
| 19 | Sat 28 Dec 2019 | 231-1 v Crystal PalaceSouthampton 1-1 Crystal Palace |
| 20 | Wed 1 Jan 2020 | 231-0 v Tottenham HotspurSouthampton 1-0 Tottenham Hotspur |
| 21 | Sat 11 Jan 2020 | 23 2-1 v Leicester CityLeicester City 1-2 Southampton |
| 22 | Sat 18 Jan 2020 | 232-3 v Wolverhampton WanderersSouthampton 2-3 Wolverhampton Wanderers |
| 23 | Tue 21 Jan 2020 | 232-0 v Crystal PalaceCrystal Palace 0-2 Southampton |
| 24 | Sat 1 Feb 2020 | 230-4 v LiverpoolLiverpool 4-0 Southampton |
| 25 | Sat 15 Feb 2020 | 231-2 v BurnleySouthampton 1-2 Burnley |
| 26 | Sat 22 Feb 2020 | 232-0 v Aston VillaSouthampton 2-0 Aston Villa |
| 27 | Sat 29 Feb 2020 | 231-3 v West Ham UnitedWest Ham United 3-1 Southampton |
| 28 | Sat 7 Mar 2020 | 230-1 v Newcastle UnitedSouthampton 0-1 Newcastle United |
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