| 1 | Mon 14 Sep 2020 | 10-2 v Wolverhampton WanderersSheffield United 0-2 Wolverhampton Wanderers |
| 2 | Mon 21 Sep 2020 | 10-1 v Aston VillaAston Villa 1-0 Sheffield United |
| 3 | Sun 27 Sep 2020 | 10-1 v Leeds UnitedSheffield United 0-1 Leeds United |
| 4 | Sun 4 Oct 2020 | 11-2 v ArsenalArsenal 2-1 Sheffield United |
| 5 | Sun 18 Oct 2020 | 11-1 v FulhamSheffield United 1-1 Fulham |
| 6 | Sat 24 Oct 2020 | 11-2 v LiverpoolLiverpool 2-1 Sheffield United |
| 7 | Sat 31 Oct 2020 | 10-1 v Manchester CitySheffield United 0-1 Manchester City |
| 8 | Sat 7 Nov 2020 | 11-4 v ChelseaChelsea 4-1 Sheffield United |
| 9 | Sun 22 Nov 2020 | 10-1 v West Ham UnitedSheffield United 0-1 West Ham United |
| 10 | Sat 28 Nov 2020 | 10-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Sheffield United |
| 11 | Sun 6 Dec 2020 | 11-2 v Leicester CitySheffield United 1-2 Leicester City |
| 12 | Sun 13 Dec 2020 | 10-3 v SouthamptonSouthampton 3-0 Sheffield United |
| 13 | Thu 17 Dec 2020 | 12-3 v Manchester UnitedSheffield United 2-3 Manchester United |
| 14 | Sun 20 Dec 2020 | 1 1-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Sheffield United |
| 15 | Sat 26 Dec 2020 | 10-1 v EvertonSheffield United 0-1 Everton |
| 16 | Tue 29 Dec 2020 | 10-1 v BurnleyBurnley 1-0 Sheffield United |
| 17 | Sat 2 Jan 2021 | 10-2 v Crystal PalaceCrystal Palace 2-0 Sheffield United |
| 18 | Tue 12 Jan 2021 | 11-0 v Newcastle UnitedSheffield United 1-0 Newcastle United |
| 19 | Sun 17 Jan 2021 | 11-3 v Tottenham HotspurSheffield United 1-3 Tottenham Hotspur |
| 20 | Wed 27 Jan 2021 | 12-1 v Manchester UnitedManchester United 1-2 Sheffield United |
| 21 | Sat 30 Jan 2021 | 10-1 v Manchester CityManchester City 1-0 Sheffield United |
| 22 | Tue 2 Feb 2021 | 12-1 v West Bromwich AlbionSheffield United 2-1 West Bromwich Albion |
| 23 | Sun 7 Feb 2021 | 11-2 v ChelseaSheffield United 1-2 Chelsea |
| 24 | Mon 15 Feb 2021 | 10-3 v West Ham UnitedWest Ham United 3-0 Sheffield United |
| 25 | Sat 20 Feb 2021 | 10-1 v FulhamFulham 1-0 Sheffield United |
| 26 | Sun 28 Feb 2021 | 10-2 v LiverpoolSheffield United 0-2 Liverpool |
| 27 | Wed 3 Mar 2021 | 11-0 v Aston VillaSheffield United 1-0 Aston Villa |
| 28 | Sat 6 Mar 2021 | 10-2 v SouthamptonSheffield United 0-2 Southampton |
| 29 | Sun 14 Mar 2021 | 10-5 v Leicester CityLeicester City 5-0 Sheffield United |
| 30 | Sat 3 Apr 2021 | 11-2 v Leeds UnitedLeeds United 2-1 Sheffield United |
| 31 | Sun 11 Apr 2021 | 10-3 v ArsenalSheffield United 0-3 Arsenal |
| 32 | Sat 17 Apr 2021 | 10-1 v Wolverhampton WanderersWolverhampton Wanderers 1-0 Sheffield United |
| 33 | Sat 24 Apr 2021 | 11-0 v Brighton & Hove AlbionSheffield United 1-0 Brighton & Hove Albion |
| 34 | Sun 2 May 2021 | 10-4 v Tottenham HotspurTottenham Hotspur 4-0 Sheffield United |
| 35 | Sat 8 May 2021 | 10-2 v Crystal PalaceSheffield United 0-2 Crystal Palace |
| 36 | Sun 16 May 2021 | 11-0 v EvertonEverton 0-1 Sheffield United |
| 37 | Wed 19 May 2021 | 10-1 v Newcastle UnitedNewcastle United 1-0 Sheffield United |
| 38 | Sun 23 May 2021 | 11-0 v BurnleySheffield United 1-0 Burnley |
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