| 1 | Mon 14 Sep 2020 | 162-0 v Sheffield UnitedSheffield United 0-2 Wolverhampton Wanderers |
| 2 | Mon 21 Sep 2020 | 161-3 v Manchester CityWolverhampton Wanderers 1-3 Manchester City |
| 3 | Sun 27 Sep 2020 | 16 0-4 v West Ham UnitedWest Ham United 4-0 Wolverhampton Wanderers |
| 4 | Sun 4 Oct 2020 | 161-0 v FulhamWolverhampton Wanderers 1-0 Fulham |
| 5 | Mon 19 Oct 2020 | 161-0 v Leeds UnitedLeeds United 0-1 Wolverhampton Wanderers |
| 6 | Sun 25 Oct 2020 | 161-1 v Newcastle UnitedWolverhampton Wanderers 1-1 Newcastle United |
| 7 | Fri 30 Oct 2020 | 162-0 v Crystal PalaceWolverhampton Wanderers 2-0 Crystal Palace |
| 8 | Sun 8 Nov 2020 | 160-1 v Leicester CityLeicester City 1-0 Wolverhampton Wanderers |
| 9 | Sun 29 Nov 2020 | 16 2-1 v ArsenalArsenal 1-2 Wolverhampton Wanderers |
| 10 | Sun 6 Dec 2020 | 160-4 v LiverpoolLiverpool 4-0 Wolverhampton Wanderers |
| 11 | Sat 12 Dec 2020 | 160-1 v Aston VillaWolverhampton Wanderers 0-1 Aston Villa |
| 12 | Tue 15 Dec 2020 | 162-1 v ChelseaWolverhampton Wanderers 2-1 Chelsea |
| 13 | Mon 21 Dec 2020 | 161-2 v BurnleyBurnley 2-1 Wolverhampton Wanderers |
| 14 | Sun 27 Dec 2020 | 16 1-1 v Tottenham HotspurWolverhampton Wanderers 1-1 Tottenham Hotspur |
| 15 | Tue 29 Dec 2020 | 160-1 v Manchester UnitedManchester United 1-0 Wolverhampton Wanderers |
| 16 | Sat 2 Jan 2021 | 163-3 v Brighton & Hove AlbionBrighton & Hove Albion 3-3 Wolverhampton Wanderers |
| 17 | Tue 12 Jan 2021 | 161-2 v EvertonWolverhampton Wanderers 1-2 Everton |
| 18 | Sat 16 Jan 2021 | 162-3 v West Bromwich AlbionWolverhampton Wanderers 2-3 West Bromwich Albion |
| 19 | Wed 27 Jan 2021 | 160-0 v ChelseaChelsea 0-0 Wolverhampton Wanderers |
| 20 | Sat 30 Jan 2021 | 16 0-1 v Crystal PalaceCrystal Palace 1-0 Wolverhampton Wanderers |
| 21 | Tue 2 Feb 2021 | 162-1 v ArsenalWolverhampton Wanderers 2-1 Arsenal |
| 22 | Sun 7 Feb 2021 | 160-0 v Leicester CityWolverhampton Wanderers 0-0 Leicester City |
| 23 | Sun 14 Feb 2021 | 162-1 v SouthamptonSouthampton 1-2 Wolverhampton Wanderers |
| 24 | Fri 19 Feb 2021 | 161-0 v Leeds UnitedWolverhampton Wanderers 1-0 Leeds United |
| 25 | Sat 27 Feb 2021 | 161-1 v Newcastle UnitedNewcastle United 1-1 Wolverhampton Wanderers |
| 26 | Tue 2 Mar 2021 | 161-4 v Manchester CityManchester City 4-1 Wolverhampton Wanderers |
| 27 | Sat 6 Mar 2021 | 160-0 v Aston VillaAston Villa 0-0 Wolverhampton Wanderers |
| 28 | Mon 15 Mar 2021 | 160-1 v LiverpoolWolverhampton Wanderers 0-1 Liverpool |
| 29 | Mon 5 Apr 2021 | 162-3 v West Ham UnitedWolverhampton Wanderers 2-3 West Ham United |
| 30 | Fri 9 Apr 2021 | 161-0 v FulhamFulham 0-1 Wolverhampton Wanderers |
| 31 | Sat 17 Apr 2021 | 161-0 v Sheffield UnitedWolverhampton Wanderers 1-0 Sheffield United |
| 32 | Sun 25 Apr 2021 | 160-4 v BurnleyWolverhampton Wanderers 0-4 Burnley |
| 33 | Mon 3 May 2021 | 161-1 v West Bromwich AlbionWest Bromwich Albion 1-1 Wolverhampton Wanderers |
| 34 | Sun 9 May 2021 | 16 2-1 v Brighton & Hove AlbionWolverhampton Wanderers 2-1 Brighton & Hove Albion |
| 35 | Sun 16 May 2021 | 160-2 v Tottenham HotspurTottenham Hotspur 2-0 Wolverhampton Wanderers |
| 36 | Wed 19 May 2021 | 160-1 v EvertonEverton 1-0 Wolverhampton Wanderers |
| 37 | Sun 23 May 2021 | 161-2 v Manchester UnitedWolverhampton Wanderers 1-2 Manchester United |
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