| 1 | Sun 13 Sep 2020 | 5 0-1 v EvertonTottenham Hotspur 0-1 Everton |
| 2 | Sun 20 Sep 2020 | 55-2 v SouthamptonSouthampton 2-5 Tottenham Hotspur |
| 3 | Sun 27 Sep 2020 | 51-1 v Newcastle UnitedTottenham Hotspur 1-1 Newcastle United |
| 4 | Sun 4 Oct 2020 | 56-1 v Manchester UnitedManchester United 1-6 Tottenham Hotspur |
| 5 | Sun 18 Oct 2020 | 53-3 v West Ham UnitedTottenham Hotspur 3-3 West Ham United |
| 6 | Mon 26 Oct 2020 | 51-0 v BurnleyBurnley 0-1 Tottenham Hotspur |
| 7 | Sun 1 Nov 2020 | 52-1 v Brighton & Hove AlbionTottenham Hotspur 2-1 Brighton & Hove Albion |
| 8 | Sun 8 Nov 2020 | 51-0 v West Bromwich AlbionWest Bromwich Albion 0-1 Tottenham Hotspur |
| 9 | Sat 21 Nov 2020 | 52-0 v Manchester CityTottenham Hotspur 2-0 Manchester City |
| 10 | Sun 29 Nov 2020 | 50-0 v ChelseaChelsea 0-0 Tottenham Hotspur |
| 11 | Sun 6 Dec 2020 | 52-0 v ArsenalTottenham Hotspur 2-0 Arsenal |
| 12 | Sun 13 Dec 2020 | 51-1 v Crystal PalaceCrystal Palace 1-1 Tottenham Hotspur |
| 13 | Wed 16 Dec 2020 | 5 1-2 v LiverpoolLiverpool 2-1 Tottenham Hotspur |
| 14 | Sun 20 Dec 2020 | 50-2 v Leicester CityTottenham Hotspur 0-2 Leicester City |
| 15 | Sun 27 Dec 2020 | 51-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Tottenham Hotspur |
| 16 | Sat 2 Jan 2021 | 5 3-0 v Leeds UnitedTottenham Hotspur 3-0 Leeds United |
| 17 | Wed 13 Jan 2021 | 5 1-1 v FulhamTottenham Hotspur 1-1 Fulham |
| 18 | Sun 17 Jan 2021 | 53-1 v Sheffield UnitedSheffield United 1-3 Tottenham Hotspur |
| 19 | Thu 28 Jan 2021 | 51-3 v LiverpoolTottenham Hotspur 1-3 Liverpool |
| 20 | Sun 31 Jan 2021 | 50-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-0 Tottenham Hotspur |
| 21 | Thu 4 Feb 2021 | 5 0-1 v ChelseaTottenham Hotspur 0-1 Chelsea |
| 22 | Sun 7 Feb 2021 | 52-0 v West Bromwich AlbionTottenham Hotspur 2-0 West Bromwich Albion |
| 23 | Sat 13 Feb 2021 | 50-3 v Manchester CityManchester City 3-0 Tottenham Hotspur |
| 24 | Sun 21 Feb 2021 | 5 1-2 v West Ham UnitedWest Ham United 2-1 Tottenham Hotspur |
| 25 | Sun 28 Feb 2021 | 54-0 v BurnleyTottenham Hotspur 4-0 Burnley |
| 26 | Thu 4 Mar 2021 | 51-0 v FulhamFulham 0-1 Tottenham Hotspur |
| 27 | Sun 7 Mar 2021 | 54-1 v Crystal PalaceTottenham Hotspur 4-1 Crystal Palace |
| 28 | Sun 14 Mar 2021 | 51-2 v ArsenalArsenal 2-1 Tottenham Hotspur |
| 29 | Sun 21 Mar 2021 | 52-0 v Aston VillaAston Villa 0-2 Tottenham Hotspur |
| 30 | Sun 4 Apr 2021 | 52-2 v Newcastle UnitedNewcastle United 2-2 Tottenham Hotspur |
| 31 | Sun 11 Apr 2021 | 51-3 v Manchester UnitedTottenham Hotspur 1-3 Manchester United |
| 32 | Fri 16 Apr 2021 | 5 2-2 v EvertonEverton 2-2 Tottenham Hotspur |
| 33 | Wed 21 Apr 2021 | 52-1 v SouthamptonTottenham Hotspur 2-1 Southampton |
| 34 | Sun 2 May 2021 | 5 4-0 v Sheffield UnitedTottenham Hotspur 4-0 Sheffield United |
| 35 | Sat 8 May 2021 | 51-3 v Leeds UnitedLeeds United 3-1 Tottenham Hotspur |
| 36 | Sun 16 May 2021 | 52-0 v Wolverhampton WanderersTottenham Hotspur 2-0 Wolverhampton Wanderers |
| 37 | Wed 19 May 2021 | 5 1-2 v Aston VillaTottenham Hotspur 1-2 Aston Villa |
| 38 | Sun 23 May 2021 | 54-2 v Leicester CityLeicester City 2-4 Tottenham Hotspur |
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