| 1 | Sat 12 Sep 2020 | 280-2 v Newcastle UnitedWest Ham United 0-2 Newcastle United |
| 2 | Sat 19 Sep 2020 | 281-2 v ArsenalArsenal 2-1 West Ham United |
| 3 | Sun 27 Sep 2020 | 284-0 v Wolverhampton WanderersWest Ham United 4-0 Wolverhampton Wanderers |
| 4 | Sun 4 Oct 2020 | 283-0 v Leicester CityLeicester City 0-3 West Ham United |
| 5 | Sun 18 Oct 2020 | 28 3-3 v Tottenham HotspurTottenham Hotspur 3-3 West Ham United |
| 6 | Sat 24 Oct 2020 | 281-1 v Manchester CityWest Ham United 1-1 Manchester City |
| 7 | Sat 31 Oct 2020 | 281-2 v LiverpoolLiverpool 2-1 West Ham United |
| 8 | Sat 7 Nov 2020 | 281-0 v FulhamWest Ham United 1-0 Fulham |
| 9 | Sun 22 Nov 2020 | 281-0 v Sheffield UnitedSheffield United 0-1 West Ham United |
| 10 | Mon 30 Nov 2020 | 282-1 v Aston VillaWest Ham United 2-1 Aston Villa |
| 11 | Sat 5 Dec 2020 | 281-3 v Manchester UnitedWest Ham United 1-3 Manchester United |
| 12 | Fri 11 Dec 2020 | 282-1 v Leeds UnitedLeeds United 1-2 West Ham United |
| 13 | Wed 16 Dec 2020 | 281-1 v Crystal PalaceWest Ham United 1-1 Crystal Palace |
| 14 | Mon 21 Dec 2020 | 280-3 v ChelseaChelsea 3-0 West Ham United |
| 15 | Sun 27 Dec 2020 | 282-2 v Brighton & Hove AlbionWest Ham United 2-2 Brighton & Hove Albion |
| 16 | Tue 29 Dec 2020 | 280-0 v SouthamptonSouthampton 0-0 West Ham United |
| 17 | Fri 1 Jan 2021 | 281-0 v EvertonEverton 0-1 West Ham United |
| 18 | Sat 16 Jan 2021 | 28 1-0 v BurnleyWest Ham United 1-0 Burnley |
| 19 | Tue 19 Jan 2021 | 282-1 v West Bromwich AlbionWest Ham United 2-1 West Bromwich Albion |
| 20 | Tue 26 Jan 2021 | 283-2 v Crystal PalaceCrystal Palace 2-3 West Ham United |
| 21 | Sun 31 Jan 2021 | 28 1-3 v LiverpoolWest Ham United 1-3 Liverpool |
| 22 | Wed 3 Feb 2021 | 283-1 v Aston VillaAston Villa 1-3 West Ham United |
| 23 | Sat 6 Feb 2021 | 28 0-0 v FulhamFulham 0-0 West Ham United |
| 24 | Mon 15 Feb 2021 | 283-0 v Sheffield UnitedWest Ham United 3-0 Sheffield United |
| 25 | Sun 21 Feb 2021 | 28 2-1 v Tottenham HotspurWest Ham United 2-1 Tottenham Hotspur |
| 26 | Sat 27 Feb 2021 | 281-2 v Manchester CityManchester City 2-1 West Ham United |
| 27 | Mon 8 Mar 2021 | 282-0 v Leeds UnitedWest Ham United 2-0 Leeds United |
| 28 | Sun 14 Mar 2021 | 280-1 v Manchester UnitedManchester United 1-0 West Ham United |
| 29 | Sun 21 Mar 2021 | 283-3 v ArsenalWest Ham United 3-3 Arsenal |
| 30 | Mon 5 Apr 2021 | 28 3-2 v Wolverhampton WanderersWolverhampton Wanderers 2-3 West Ham United |
| 31 | Sun 11 Apr 2021 | 28 3-2 v Leicester CityWest Ham United 3-2 Leicester City |
| 32 | Sat 17 Apr 2021 | 282-3 v Newcastle UnitedNewcastle United 3-2 West Ham United |
| 33 | Sat 24 Apr 2021 | 280-1 v ChelseaWest Ham United 0-1 Chelsea |
| 34 | Mon 3 May 2021 | 282-1 v BurnleyBurnley 1-2 West Ham United |
| 35 | Sun 9 May 2021 | 28 0-1 v EvertonWest Ham United 0-1 Everton |
| 36 | Sat 15 May 2021 | 281-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 West Ham United |
| 37 | Wed 19 May 2021 | 283-1 v West Bromwich AlbionWest Bromwich Albion 1-3 West Ham United |
| 38 | Sun 23 May 2021 | 283-0 v SouthamptonWest Ham United 3-0 Southampton |
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