| 1 | Sat 14 Sep | 260-3 v Manchester UnitedSouthampton 0-3 Manchester United |
| 2 | Sat 21 Sep | 261-1 v Ipswich TownSouthampton 1-1 Ipswich Town |
| 3 | Mon 30 Sep | 261-3 v AFC BournemouthAFC Bournemouth 3-1 Southampton |
| 4 | Sat 2 Nov | 261-0 v EvertonSouthampton 1-0 Everton |
| 5 | Sat 9 Nov | 26 0-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton |
| 6 | Sun 24 Nov | 262-3 v LiverpoolSouthampton 2-3 Liverpool |
| 7 | Sun 22 Dec | 26 0-0 v FulhamFulham 0-0 Southampton |
| 8 | Thu 26 Dec | 260-1 v West Ham UnitedSouthampton 0-1 West Ham United |
| 9 | Sun 29 Dec | 261-2 v Crystal PalaceCrystal Palace 2-1 Southampton |
| 10 | Sat 4 Jan | 260-5 v BrentfordSouthampton 0-5 Brentford |
| 11 | Thu 16 Jan | 261-3 v Manchester UnitedManchester United 3-1 Southampton |
| 12 | Sun 19 Jan | 26 2-3 v Nottingham ForestNottingham Forest 3-2 Southampton |
| 13 | Sat 25 Jan | 261-3 v Newcastle UnitedSouthampton 1-3 Newcastle United |
| 14 | Sat 1 Feb | 262-1 v Ipswich TownIpswich Town 1-2 Southampton |
| 15 | Sat 15 Feb | 261-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth |
| 16 | Sat 22 Feb | 26 0-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion |
| 17 | Sat 8 Mar | 261-3 v LiverpoolLiverpool 3-1 Southampton |
| 18 | Sat 15 Mar | 261-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers |
| 19 | Wed 2 Apr | 261-1 v Crystal PalaceSouthampton 1-1 Crystal Palace |
| 20 | Sun 6 Apr | 26 1-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton |
| 21 | Sat 12 Apr | 260-3 v Aston VillaSouthampton 0-3 Aston Villa |
| 22 | Sat 19 Apr | 261-1 v West Ham UnitedWest Ham United 1-1 Southampton |
| 23 | Sat 26 Apr | 261-2 v FulhamSouthampton 1-2 Fulham |
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