| 1 | Sat 5 Oct | 321-3 v ArsenalArsenal 3-1 Southampton |
| 2 | Sat 19 Oct | 322-3 v Leicester CitySouthampton 2-3 Leicester City |
| 3 | Sat 26 Oct | 320-1 v Manchester CityManchester City 1-0 Southampton |
| 4 | Sat 2 Nov | 32 1-0 v EvertonSouthampton 1-0 Everton |
| 5 | Sat 9 Nov | 320-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton |
| 6 | Sun 24 Nov | 322-3 v LiverpoolSouthampton 2-3 Liverpool |
| 7 | Sun 22 Dec | 320-0 v FulhamFulham 0-0 Southampton |
| 8 | Thu 26 Dec | 320-1 v West Ham UnitedSouthampton 0-1 West Ham United |
| 9 | Sun 29 Dec | 321-2 v Crystal PalaceCrystal Palace 2-1 Southampton |
| 10 | Sat 4 Jan | 320-5 v BrentfordSouthampton 0-5 Brentford |
| 11 | Thu 16 Jan | 321-3 v Manchester UnitedManchester United 3-1 Southampton |
| 12 | Sun 19 Jan | 322-3 v Nottingham ForestNottingham Forest 3-2 Southampton |
| 13 | Sat 25 Jan | 321-3 v Newcastle UnitedSouthampton 1-3 Newcastle United |
| 14 | Sat 1 Feb | 322-1 v Ipswich TownIpswich Town 1-2 Southampton |
| 15 | Sat 15 Feb | 321-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth |
| 16 | Sat 22 Feb | 320-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion |
| 17 | Tue 25 Feb | 32 0-4 v ChelseaChelsea 4-0 Southampton |
| 18 | Sat 8 Mar | 32 1-3 v LiverpoolLiverpool 3-1 Southampton |
| 19 | Sat 15 Mar | 321-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers |
| 20 | Wed 2 Apr | 321-1 v Crystal PalaceSouthampton 1-1 Crystal Palace |
| 21 | Sun 6 Apr | 321-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton |
| 22 | Sat 12 Apr | 320-3 v Aston VillaSouthampton 0-3 Aston Villa |
| 23 | Sat 19 Apr | 32 1-1 v West Ham UnitedWest Ham United 1-1 Southampton |
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