| 1 | Sat 17 Aug | 330-1 v Newcastle UnitedNewcastle United 1-0 Southampton |
| 2 | Sat 24 Aug | 330-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest |
| 3 | Sat 31 Aug | 331-3 v BrentfordBrentford 3-1 Southampton |
| 4 | Sat 14 Sep | 330-3 v Manchester UnitedSouthampton 0-3 Manchester United |
| 5 | Sat 21 Sep | 331-1 v Ipswich TownSouthampton 1-1 Ipswich Town |
| 6 | Mon 30 Sep | 33 1-3 v AFC BournemouthAFC Bournemouth 3-1 Southampton |
| 7 | Sat 5 Oct | 33 1-3 v ArsenalArsenal 3-1 Southampton |
| 8 | Sat 19 Oct | 33 2-3 v Leicester CitySouthampton 2-3 Leicester City |
| 9 | Sat 26 Oct | 330-1 v Manchester CityManchester City 1-0 Southampton |
| 10 | Sat 2 Nov | 33 1-0 v EvertonSouthampton 1-0 Everton |
| 11 | Sat 9 Nov | 330-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton |
| 12 | Sun 24 Nov | 332-3 v LiverpoolSouthampton 2-3 Liverpool |
| 13 | Fri 29 Nov | 33 1-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton |
| 14 | Sat 7 Dec | 330-1 v Aston VillaAston Villa 1-0 Southampton |
| 15 | Sun 15 Dec | 330-5 v Tottenham HotspurSouthampton 0-5 Tottenham Hotspur |
| 16 | Sun 22 Dec | 330-0 v FulhamFulham 0-0 Southampton |
| 17 | Thu 26 Dec | 330-1 v West Ham UnitedSouthampton 0-1 West Ham United |
| 18 | Sun 29 Dec | 331-2 v Crystal PalaceCrystal Palace 2-1 Southampton |
| 19 | Sat 4 Jan | 330-5 v BrentfordSouthampton 0-5 Brentford |
| 20 | Thu 16 Jan | 33 1-3 v Manchester UnitedManchester United 3-1 Southampton |
| 21 | Sat 15 Feb | 331-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth |
| 22 | Sat 22 Feb | 330-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion |
| 23 | Tue 25 Feb | 330-4 v ChelseaChelsea 4-0 Southampton |
| 24 | Sat 8 Mar | 331-3 v LiverpoolLiverpool 3-1 Southampton |
| 25 | Sat 15 Mar | 331-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers |
| 26 | Wed 2 Apr | 331-1 v Crystal PalaceSouthampton 1-1 Crystal Palace |
| 27 | Sun 6 Apr | 331-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton |
| 28 | Sat 12 Apr | 330-3 v Aston VillaSouthampton 0-3 Aston Villa |
| 29 | Sat 19 Apr | 331-1 v West Ham UnitedWest Ham United 1-1 Southampton |
| 30 | Sat 26 Apr | 331-2 v FulhamSouthampton 1-2 Fulham |
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