| 1 | 21/7/2021 | 315-1 v GalatasarayPSV Eindhoven 5-1 Galatasaray | UEFA Champions League Second Qualifying Round |
| 2 | 28/7/2021 | 312-1 v GalatasarayGalatasaray 1-2 PSV Eindhoven | UEFA Champions League Second Qualifying Round |
| 3 | 3/8/2021 | 313-0 v FC MidtjyllandPSV Eindhoven 3-0 FC Midtjylland | UEFA Champions League Third Qualifying Round |
| 4 | 10/8/2021 | 311-0 v FC MidtjyllandFC Midtjylland 0-1 PSV Eindhoven | UEFA Champions League Third Qualifying Round |
| 5 | 18/8/2021 | 311-2 v BenficaBenfica 2-1 PSV Eindhoven | UEFA Champions League Qualifying Play-off Round |
| 6 | 24/8/2021 | 310-0 v BenficaPSV Eindhoven 0-0 Benfica | UEFA Champions League Qualifying Play-off Round |
| 7 | 28/8/2021 | 315-2 v FC GroningenPSV Eindhoven 5-2 FC Groningen | Dutch Eredivisie |
| 8 | 11/9/2021 | 313-0 v AZ AlkmaarAZ Alkmaar 0-3 PSV Eindhoven | Dutch Eredivisie |
| 9 | 16/9/2021 | 312-2 v Real SociedadPSV Eindhoven 2-2 Real Sociedad | UEFA Europa League Group B |
| 10 | 19/9/2021 | 310-4 v FeyenoordPSV Eindhoven 0-4 Feyenoord | Dutch Eredivisie |
| 11 | 22/9/2021 | 31 2-1 v Go Ahead EaglesGo Ahead Eagles 1-2 PSV Eindhoven | Dutch Eredivisie |
| 12 | 25/9/2021 | 311-2 v Willem IIWillem II 2-1 PSV Eindhoven | Dutch Eredivisie |
| 13 | 30/9/2021 | 314-1 v Sturm GrazSturm Graz 1-4 PSV Eindhoven | UEFA Europa League Group B |
| 14 | 3/10/2021 | 312-1 v Sparta RotterdamPSV Eindhoven 2-1 Sparta Rotterdam | Dutch Eredivisie |
| 15 | 16/10/2021 | 313-1 v PEC ZwollePSV Eindhoven 3-1 PEC Zwolle | Dutch Eredivisie |
| 16 | 21/10/2021 | 311-2 v MonacoPSV Eindhoven 1-2 Monaco | UEFA Europa League Group B |
| 17 | 24/10/2021 | 31 0-5 v AjaxAjax 5-0 PSV Eindhoven | Dutch Eredivisie |
| 18 | 30/10/2021 | 315-2 v FC TwentePSV Eindhoven 5-2 FC Twente | Dutch Eredivisie |
| 19 | 4/11/2021 | 310-0 v MonacoMonaco 0-0 PSV Eindhoven | UEFA Europa League Group B |
| 20 | 7/11/2021 | 314-1 v Fortuna SittardFortuna Sittard 1-4 PSV Eindhoven | Dutch Eredivisie |
| 21 | 9/12/2021 | 310-3 v Real SociedadReal Sociedad 3-0 PSV Eindhoven | UEFA Europa League Group B |
| 22 | 12/12/2021 | 312-1 v NEC NijmegenNEC Nijmegen 1-2 PSV Eindhoven | Dutch Eredivisie |
| 23 | 19/12/2021 | 314-1 v RKC WaalwijkRKC Waalwijk 1-4 PSV Eindhoven | Dutch Eredivisie |
| 24 | 23/12/2021 | 312-0 v Go Ahead EaglesPSV Eindhoven 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 25 | 16/1/2022 | 311-0 v FC GroningenFC Groningen 0-1 PSV Eindhoven | Dutch Eredivisie |
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