| 1 | Sat 10 Aug | 65-1 v RKC WaalwijkPSV Eindhoven 5-1 RKC Waalwijk | Dutch Eredivisie |
| 2 | Sun 18 Aug | 63-1 v Heracles AlmeloHeracles Almelo 1-3 PSV Eindhoven | Dutch Eredivisie |
| 3 | Sat 24 Aug | 67-1 v Almere CityAlmere City 1-7 PSV Eindhoven | Dutch Eredivisie |
| 4 | Sun 1 Sep | 63-0 v Go Ahead EaglesPSV Eindhoven 3-0 Go Ahead Eagles | Dutch Eredivisie |
| 5 | Sat 14 Sep | 62-0 v NEC NijmegenPSV Eindhoven 2-0 NEC Nijmegen | Dutch Eredivisie |
| 6 | Tue 17 Sep | 61-3 v JuventusJuventus 3-1 PSV Eindhoven | UEFA Champions League Matchday 1 |
| 7 | Sun 22 Sep | 63-1 v Fortuna SittardFortuna Sittard 1-3 PSV Eindhoven | Dutch Eredivisie |
| 8 | Sat 28 Sep | 62-0 v Willem IIWillem II 0-2 PSV Eindhoven | Dutch Eredivisie |
| 9 | Tue 1 Oct | 61-1 v Sporting CPPSV Eindhoven 1-1 Sporting CP | UEFA Champions League Matchday 2 |
| 10 | Sat 5 Oct | 62-1 v Sparta RotterdamPSV Eindhoven 2-1 Sparta Rotterdam | Dutch Eredivisie |
| 11 | Sat 19 Oct | 62-1 v AZ AlkmaarAZ Alkmaar 1-2 PSV Eindhoven | Dutch Eredivisie |
| 12 | Tue 22 Oct | 61-1 v Paris St GermainParis St Germain 1-1 PSV Eindhoven | UEFA Champions League Matchday 3 |
| 13 | Sat 26 Oct | 66-0 v PEC ZwollePSV Eindhoven 6-0 PEC Zwolle | Dutch Eredivisie |
| 14 | Sat 2 Nov | 6 2-3 v AjaxAjax 3-2 PSV Eindhoven | Dutch Eredivisie |
| 15 | Tue 5 Nov | 64-0 v GironaPSV Eindhoven 4-0 Girona | UEFA Champions League Matchday 4 |
| 16 | Sat 9 Nov | 63-0 v NAC BredaNAC Breda 0-3 PSV Eindhoven | Dutch Eredivisie |
| 17 | Sat 23 Nov | 65-0 v FC GroningenPSV Eindhoven 5-0 FC Groningen | Dutch Eredivisie |
| 18 | Wed 27 Nov | 63-2 v Shakhtar DonetskPSV Eindhoven 3-2 Shakhtar Donetsk | UEFA Champions League Matchday 5 |
| 19 | Sun 1 Dec | 6 5-2 v FC UtrechtFC Utrecht 2-5 PSV Eindhoven | Dutch Eredivisie |
| 20 | Fri 6 Dec | 66-1 v FC TwentePSV Eindhoven 6-1 FC Twente | Dutch Eredivisie |
| 21 | Tue 10 Dec | 60-1 v BrestBrest 1-0 PSV Eindhoven | UEFA Champions League Matchday 6 |
| 22 | Sat 14 Dec | 60-1 v sc Heerenveensc Heerenveen 1-0 PSV Eindhoven | Dutch Eredivisie |
| 23 | Sun 22 Dec | 63-0 v FeyenoordPSV Eindhoven 3-0 Feyenoord | Dutch Eredivisie |
| 24 | Sat 11 Jan | 62-2 v AZ AlkmaarPSV Eindhoven 2-2 AZ Alkmaar | Dutch Eredivisie |
| 25 | Sat 18 Jan | 61-3 v PEC ZwollePEC Zwolle 3-1 PSV Eindhoven | Dutch Eredivisie |
| 26 | Tue 21 Jan | 6 3-2 v Crvena ZvezdaCrvena Zvezda 2-3 PSV Eindhoven | UEFA Champions League Matchday 7 |
| 27 | Sat 25 Jan | 63-2 v NAC BredaPSV Eindhoven 3-2 NAC Breda | Dutch Eredivisie |
| 28 | Sat 1 Feb | 63-3 v NEC NijmegenNEC Nijmegen 3-3 PSV Eindhoven | Dutch Eredivisie |
| 29 | Sat 8 Feb | 61-1 v Willem IIPSV Eindhoven 1-1 Willem II | Dutch Eredivisie |
| 30 | Tue 11 Feb | 61-2 v JuventusJuventus 2-1 PSV Eindhoven | UEFA Champions League Play-off Knockout Round |
| 31 | Sat 15 Feb | 62-2 v FC UtrechtPSV Eindhoven 2-2 FC Utrecht | Dutch Eredivisie |
| 32 | Wed 19 Feb | 63-1 v JuventusPSV Eindhoven 3-1 Juventus | UEFA Champions League Play-off Knockout Round |
| 33 | Sat 1 Mar | 62-3 v Go Ahead EaglesGo Ahead Eagles 3-2 PSV Eindhoven | Dutch Eredivisie |
| 34 | Tue 4 Mar | 61-7 v ArsenalPSV Eindhoven 1-7 Arsenal | UEFA Champions League Round of 16 |
| 35 | Sat 8 Mar | 62-1 v sc HeerenveenPSV Eindhoven 2-1 sc Heerenveen | Dutch Eredivisie |
| 36 | Wed 12 Mar | 62-2 v ArsenalArsenal 2-2 PSV Eindhoven | UEFA Champions League Round of 16 |
| 37 | Sat 15 Mar | 63-0 v RKC WaalwijkRKC Waalwijk 0-3 PSV Eindhoven | Dutch Eredivisie |
| 38 | Sun 30 Mar | 60-2 v AjaxPSV Eindhoven 0-2 Ajax | Dutch Eredivisie |
| 39 | Sat 5 Apr | 63-1 v FC GroningenFC Groningen 1-3 PSV Eindhoven | Dutch Eredivisie |
| 40 | Sat 12 Apr | 65-0 v Almere CityPSV Eindhoven 5-0 Almere City | Dutch Eredivisie |
| 41 | Thu 24 Apr | 63-1 v FC TwenteFC Twente 1-3 PSV Eindhoven | Dutch Eredivisie |
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