| 1 | 20/9/2020 | 253-1 v Mainz 05RB Leipzig 3-1 Mainz 05 | German Bundesliga |
| 2 | 26/9/2020 | 251-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-1 RB Leipzig | German Bundesliga |
| 3 | 3/10/2020 | 254-0 v FC Schalke 04RB Leipzig 4-0 FC Schalke 04 | German Bundesliga |
| 4 | 17/10/2020 | 252-0 v FC AugsburgFC Augsburg 0-2 RB Leipzig | German Bundesliga |
| 5 | 20/10/2020 | 252-0 v İstanbul BaşakşehirRB Leipzig 2-0 İstanbul Başakşehir | UEFA Champions League Group H |
| 6 | 24/10/2020 | 252-1 v Hertha BerlinRB Leipzig 2-1 Hertha Berlin | German Bundesliga |
| 7 | 28/10/2020 | 250-5 v Manchester UnitedManchester United 5-0 RB Leipzig | UEFA Champions League Group H |
| 8 | 31/10/2020 | 250-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-0 RB Leipzig | German Bundesliga |
| 9 | 4/11/2020 | 252-1 v Paris St GermainRB Leipzig 2-1 Paris St Germain | UEFA Champions League Group H |
| 10 | 7/11/2020 | 253-0 v SC FreiburgRB Leipzig 3-0 SC Freiburg | German Bundesliga |
| 11 | 21/11/2020 | 25 1-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 RB Leipzig | German Bundesliga |
| 12 | 24/11/2020 | 250-1 v Paris St GermainParis St Germain 1-0 RB Leipzig | UEFA Champions League Group H |
| 13 | 28/11/2020 | 252-1 v Arminia BielefeldRB Leipzig 2-1 Arminia Bielefeld | German Bundesliga |
| 14 | 2/12/2020 | 25 4-3 v İstanbul Başakşehirİstanbul Başakşehir 3-4 RB Leipzig | UEFA Champions League Group H |
| 15 | 5/12/2020 | 253-3 v Bayern MunichBayern Munich 3-3 RB Leipzig | German Bundesliga |
| 16 | 8/12/2020 | 253-2 v Manchester UnitedRB Leipzig 3-2 Manchester United | UEFA Champions League Group H |
| 17 | 12/12/2020 | 252-0 v Werder BremenRB Leipzig 2-0 Werder Bremen | German Bundesliga |
| 18 | 16/12/2020 | 251-0 v 1899 Hoffenheim1899 Hoffenheim 0-1 RB Leipzig | German Bundesliga |
| 19 | 19/12/2020 | 250-0 v 1. FC KölnRB Leipzig 0-0 1. FC Köln | German Bundesliga |
| 20 | 2/1/2021 | 251-0 v VfB StuttgartVfB Stuttgart 0-1 RB Leipzig | German Bundesliga |
| 21 | 9/1/2021 | 251-3 v Borussia DortmundRB Leipzig 1-3 Borussia Dortmund | German Bundesliga |
| 22 | 16/1/2021 | 252-2 v VfL WolfsburgVfL Wolfsburg 2-2 RB Leipzig | German Bundesliga |
| 23 | 20/1/2021 | 251-0 v 1. FC Union BerlinRB Leipzig 1-0 1. FC Union Berlin | German Bundesliga |
| 24 | 23/1/2021 | 252-3 v Mainz 05Mainz 05 3-2 RB Leipzig | German Bundesliga |
| 25 | 30/1/2021 | 251-0 v Bayer 04 LeverkusenRB Leipzig 1-0 Bayer 04 Leverkusen | German Bundesliga |
| 26 | 6/2/2021 | 253-0 v FC Schalke 04FC Schalke 04 0-3 RB Leipzig | German Bundesliga |
| 27 | 12/2/2021 | 252-1 v FC AugsburgRB Leipzig 2-1 FC Augsburg | German Bundesliga |
| 28 | 16/2/2021 | 25 0-2 v LiverpoolRB Leipzig 0-2 Liverpool | UEFA Champions League Round of 16 |
| 29 | 21/2/2021 | 253-0 v Hertha BerlinHertha Berlin 0-3 RB Leipzig | German Bundesliga |
| 30 | 27/2/2021 | 253-2 v Borussia MönchengladbachRB Leipzig 3-2 Borussia Mönchengladbach | German Bundesliga |
| 31 | 6/3/2021 | 253-0 v SC FreiburgSC Freiburg 0-3 RB Leipzig | German Bundesliga |
| 32 | 10/3/2021 | 250-2 v LiverpoolLiverpool 2-0 RB Leipzig | UEFA Champions League Round of 16 |
| 33 | 14/3/2021 | 251-1 v Eintracht FrankfurtRB Leipzig 1-1 Eintracht Frankfurt | German Bundesliga |
| 34 | 19/3/2021 | 251-0 v Arminia BielefeldArminia Bielefeld 0-1 RB Leipzig | German Bundesliga |
| 35 | 3/4/2021 | 250-1 v Bayern MunichRB Leipzig 0-1 Bayern Munich | German Bundesliga |
| 36 | 10/4/2021 | 254-1 v Werder BremenWerder Bremen 1-4 RB Leipzig | German Bundesliga |
| 37 | 16/4/2021 | 250-0 v 1899 HoffenheimRB Leipzig 0-0 1899 Hoffenheim | German Bundesliga |
| 38 | 20/4/2021 | 251-2 v 1. FC Köln1. FC Köln 2-1 RB Leipzig | German Bundesliga |
| 39 | 25/4/2021 | 252-0 v VfB StuttgartRB Leipzig 2-0 VfB Stuttgart | German Bundesliga |
| 40 | 8/5/2021 | 252-3 v Borussia DortmundBorussia Dortmund 3-2 RB Leipzig | German Bundesliga |
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