| 1 | Sat 24 Aug | 81-0 v VfL BochumRB Leipzig 1-0 VfL Bochum | German Bundesliga |
| 2 | Sat 31 Aug | 83-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-3 RB Leipzig | German Bundesliga |
| 3 | Sat 14 Sep | 8 0-0 v 1 FC Union BerlinRB Leipzig 0-0 1 FC Union Berlin | German Bundesliga |
| 4 | Thu 19 Sep | 81-2 v Atlético MadridAtlético Madrid 2-1 RB Leipzig | UEFA Champions League Matchday 1 |
| 5 | Sun 22 Sep | 8 0-0 v FC St PauliFC St Pauli 0-0 RB Leipzig | German Bundesliga |
| 6 | Sat 28 Sep | 84-0 v FC AugsburgRB Leipzig 4-0 FC Augsburg | German Bundesliga |
| 7 | Wed 2 Oct | 82-3 v JuventusRB Leipzig 2-3 Juventus | UEFA Champions League Matchday 2 |
| 8 | Sun 6 Oct | 81-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 RB Leipzig | German Bundesliga |
| 9 | Sat 19 Oct | 8 2-0 v Mainz 05Mainz 05 0-2 RB Leipzig | German Bundesliga |
| 10 | Wed 23 Oct | 80-1 v LiverpoolRB Leipzig 0-1 Liverpool | UEFA Champions League Matchday 3 |
| 11 | Sat 26 Oct | 83-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg | German Bundesliga |
| 12 | Sat 2 Nov | 81-2 v Borussia DortmundBorussia Dortmund 2-1 RB Leipzig | German Bundesliga |
| 13 | Tue 5 Nov | 81-3 v CelticCeltic 3-1 RB Leipzig | UEFA Champions League Matchday 4 |
| 14 | Sat 9 Nov | 8 0-0 v Borussia MönchengladbachRB Leipzig 0-0 Borussia Mönchengladbach | German Bundesliga |
| 15 | Sat 23 Nov | 83-4 v 1899 Hoffenheim1899 Hoffenheim 4-3 RB Leipzig | German Bundesliga |
| 16 | Tue 26 Nov | 80-1 v Inter MilanInter Milan 1-0 RB Leipzig | UEFA Champions League Matchday 5 |
| 17 | Sat 30 Nov | 81-5 v VfL WolfsburgRB Leipzig 1-5 VfL Wolfsburg | German Bundesliga |
| 18 | Sat 7 Dec | 82-0 v Holstein KielHolstein Kiel 0-2 RB Leipzig | German Bundesliga |
| 19 | Tue 10 Dec | 82-3 v Aston VillaRB Leipzig 2-3 Aston Villa | UEFA Champions League Matchday 6 |
| 20 | Sun 12 Jan | 8 4-2 v Werder BremenRB Leipzig 4-2 Werder Bremen | German Bundesliga |
| 21 | Sat 18 Jan | 83-3 v VfL BochumVfL Bochum 3-3 RB Leipzig | German Bundesliga |
| 22 | Wed 22 Jan | 82-1 v Sporting CPRB Leipzig 2-1 Sporting CP | UEFA Champions League Matchday 7 |
| 23 | Sat 25 Jan | 82-2 v Bayer 04 LeverkusenRB Leipzig 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 24 | Wed 29 Jan | 8 0-1 v Sturm GrazSturm Graz 1-0 RB Leipzig | UEFA Champions League Matchday 8 |
| 25 | Sat 1 Feb | 80-0 v 1 FC Union Berlin1 FC Union Berlin 0-0 RB Leipzig | German Bundesliga |
| 26 | Sun 9 Feb | 82-0 v FC St PauliRB Leipzig 2-0 FC St Pauli | German Bundesliga |
| 27 | Fri 14 Feb | 80-0 v FC AugsburgFC Augsburg 0-0 RB Leipzig | German Bundesliga |
| 28 | Sat 1 Mar | 8 1-2 v Mainz 05RB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 29 | Sat 8 Mar | 80-0 v SC FreiburgSC Freiburg 0-0 RB Leipzig | German Bundesliga |
| 30 | Sat 15 Mar | 8 2-0 v Borussia DortmundRB Leipzig 2-0 Borussia Dortmund | German Bundesliga |
| 31 | Sat 29 Mar | 80-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-0 RB Leipzig | German Bundesliga |
| 32 | Sat 5 Apr | 83-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 33 | Fri 11 Apr | 83-2 v VfL WolfsburgVfL Wolfsburg 2-3 RB Leipzig | German Bundesliga |
| 34 | Sat 19 Apr | 81-1 v Holstein KielRB Leipzig 1-1 Holstein Kiel | German Bundesliga |
| 35 | Sat 26 Apr | 80-4 v Eintracht FrankfurtEintracht Frankfurt 4-0 RB Leipzig | German Bundesliga |
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