| 1 | Sat 24 Aug | 221-0 v VfL BochumRB Leipzig 1-0 VfL Bochum | German Bundesliga |
| 2 | Sat 31 Aug | 223-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-3 RB Leipzig | German Bundesliga |
| 3 | Sat 14 Sep | 220-0 v 1 FC Union BerlinRB Leipzig 0-0 1 FC Union Berlin | German Bundesliga |
| 4 | Thu 19 Sep | 221-2 v Atlético MadridAtlético Madrid 2-1 RB Leipzig | UEFA Champions League Matchday 1 |
| 5 | Sun 22 Sep | 220-0 v FC St PauliFC St Pauli 0-0 RB Leipzig | German Bundesliga |
| 6 | Sat 28 Sep | 224-0 v FC AugsburgRB Leipzig 4-0 FC Augsburg | German Bundesliga |
| 7 | Wed 2 Oct | 22 2-3 v JuventusRB Leipzig 2-3 Juventus | UEFA Champions League Matchday 2 |
| 8 | Sun 6 Oct | 221-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 RB Leipzig | German Bundesliga |
| 9 | Fri 20 Dec | 221-5 v Bayern MunichBayern Munich 5-1 RB Leipzig | German Bundesliga |
| 10 | Sun 12 Jan | 224-2 v Werder BremenRB Leipzig 4-2 Werder Bremen | German Bundesliga |
| 11 | Wed 15 Jan | 22 1-2 v VfB StuttgartVfB Stuttgart 2-1 RB Leipzig | German Bundesliga |
| 12 | Sat 18 Jan | 223-3 v VfL BochumVfL Bochum 3-3 RB Leipzig | German Bundesliga |
| 13 | Wed 22 Jan | 22 2-1 v Sporting CPRB Leipzig 2-1 Sporting CP | UEFA Champions League Matchday 7 |
| 14 | Sat 25 Jan | 222-2 v Bayer 04 LeverkusenRB Leipzig 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 15 | Wed 29 Jan | 220-1 v Sturm GrazSturm Graz 1-0 RB Leipzig | UEFA Champions League Matchday 8 |
| 16 | Sat 1 Feb | 220-0 v 1 FC Union Berlin1 FC Union Berlin 0-0 RB Leipzig | German Bundesliga |
| 17 | Sun 9 Feb | 222-0 v FC St PauliRB Leipzig 2-0 FC St Pauli | German Bundesliga |
| 18 | Fri 14 Feb | 220-0 v FC AugsburgFC Augsburg 0-0 RB Leipzig | German Bundesliga |
| 19 | Sun 23 Feb | 222-2 v 1 FC HeidenheimRB Leipzig 2-2 1 FC Heidenheim | German Bundesliga |
| 20 | Sat 1 Mar | 221-2 v Mainz 05RB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 21 | Sat 8 Mar | 22 0-0 v SC FreiburgSC Freiburg 0-0 RB Leipzig | German Bundesliga |
| 22 | Sat 15 Mar | 22 2-0 v Borussia DortmundRB Leipzig 2-0 Borussia Dortmund | German Bundesliga |
| 23 | Sat 29 Mar | 220-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-0 RB Leipzig | German Bundesliga |
| 24 | Sat 5 Apr | 223-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
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